{"id":"memantine-matched-placebo-capsule","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL807","moleculeType":"Small molecule","molecularWeight":"179.31"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a placebo control, this capsule contains no active pharmaceutical ingredient and is designed to be indistinguishable from memantine capsules in clinical trials. Memantine itself works by blocking NMDA glutamate receptors to reduce excitotoxicity in the brain, but this matched placebo serves only as a control comparator in research studies.","oneSentence":"This is a placebo capsule formulated to match memantine, an NMDA receptor antagonist used in Alzheimer's disease treatment.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:17.313Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Control arm in clinical trials (not a therapeutic agent)"}]},"trialDetails":[{"nctId":"NCT03527472","phase":"PHASE2","title":"Memantine for the Treatment of Cognitive Impairment in Systemic Lupus Erythematosus","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2018-08-23","conditions":"Lupus Erythematosus, Systemic","enrollment":111},{"nctId":"NCT03779672","phase":"PHASE4","title":"Memantine for Epileptic Encephalopathy","status":"COMPLETED","sponsor":"Kenneth Myers, MD","startDate":"2019-02-07","conditions":"Epileptic Encephalopathy, Childhood-Onset","enrollment":30},{"nctId":"NCT02950233","phase":"PHASE3","title":"Preventing pAIn With NMDA Antagonists - Steroids in Thoracoscopic lObectomy Procedures (PAIN-STOP) Pilot Trial","status":"TERMINATED","sponsor":"Population Health Research Institute","startDate":"2017-05-04","conditions":"Pain, Postoperative","enrollment":27},{"nctId":"NCT01656187","phase":"PHASE4","title":"Attenuation of Corticosteroid Induced Hippocampal Changes","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2012-01","conditions":"Organic Memory Impairment","enrollment":46},{"nctId":"NCT03038035","phase":"PHASE2","title":"The Alzheimer's Disease THErapy With NEuroaid (ATHENE) Study","status":"UNKNOWN","sponsor":"National University Hospital, Singapore","startDate":"2016-12","conditions":"Alzheimer Disease","enrollment":150},{"nctId":"NCT01052662","phase":"PHASE2, PHASE3","title":"Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2009-10","conditions":"Opioid Dependence","enrollment":87},{"nctId":"NCT00235716","phase":"PHASE3","title":"A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease","status":"COMPLETED","sponsor":"US Department of Veterans Affairs","startDate":"2007-08","conditions":"Alzheimer's Disease","enrollment":613},{"nctId":"NCT00322153","phase":"PHASE3","title":"A Study of the Safety and Efficacy of Memantine in Moderate to Severe Alzheimer's Disease","status":"COMPLETED","sponsor":"Forest Laboratories","startDate":"2005-06","conditions":"Dementia of the Alzheimer's Type","enrollment":677}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":425,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Sugar pill"],"phase":"marketed","status":"active","brandName":"Memantine-matched Placebo capsule","genericName":"Memantine-matched Placebo capsule","companyName":"University of Texas Southwestern Medical Center","companyId":"university-of-texas-southwestern-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Memantine is a small molecule used in clinical trials for various conditions, including Alzheimer's disease, opioid dependence, and pain, and is administered as a capsule. Memantine is a placebo-matched capsule, indicating that it is compared to a capsule containing no active ingredient in clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}