{"id":"melinamide","rwe":[{"pmid":"9914520","year":"1999","title":"Formation of fatty acid ethyl esters in rat liver microsomes. Evidence for a key role for acyl-CoA: ethanol O-acyltransferase.","finding":"","journal":"European journal of biochemistry","studyType":"Clinical Study"},{"pmid":"9593225","year":"1998","title":"Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: possible role of hepatic ACAT in very low density lipoprotein secretion.","finding":"","journal":"Japanese journal of pharmacology","studyType":"Clinical Study"},{"pmid":"9503394","year":"1997","title":"[Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells].","finding":"","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica","studyType":"Clinical Study"},{"pmid":"8624784","year":"1996","title":"Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase.","finding":"","journal":"Arteriosclerosis, thrombosis, and vascular biology","studyType":"Clinical Study"},{"pmid":"8847832","year":"1995","title":"Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats.","finding":"","journal":"Japanese journal of pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dl-alpha-methylbenzyl linoleamide","offLabel":[],"synonyms":["melinamide","DL-alpha-Methylbenzyl linoleamide"],"timeline":[],"approvals":[],"brandName":"Dl-Alpha-Methylbenzyl Linoleamide","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine MELINAMIDE as a key that fits into a lock in the body. When it binds to the lock, it triggers a series of events that help to treat a particular condition. This process is complex and involves many different molecules and cellular pathways.","oneSentence":"MELINAMIDE is a small molecule that works by interacting with a specific target in the body to produce a therapeutic effect.","technicalDetail":"MELINAMIDE's mechanism of action is not well understood, but it is believed to involve the modulation of a specific protein or receptor, leading to changes in cellular signaling and gene expression."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1674","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MELINAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:33:44.620074","biosimilars":[],"competitors":[],"genericName":"melinamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"JJ07049A84","CHEBI":"CHEBI:31814","INN_ID":"2993","UMLSCUI":"C0067477","ChEMBL_ID":"CHEMBL2104478","KEGG_DRUG":"D01202","PUBCHEM_CID":"20054967"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":12,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1999 Jan","pmid":"9914520","title":"Formation of fatty acid ethyl esters in rat liver microsomes. Evidence for a key role for acyl-CoA: ethanol O-acyltransferase.","journal":"European journal of biochemistry"},{"date":"1998 Mar","pmid":"9593225","title":"Effects of F-1394, an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on ACAT activity in HepG2 cells and on hepatic secretion of lipids in Triton WR-1339-induced hyperlipidemic rats: possible role of hepatic ACAT in very low density lipoprotein secretion.","journal":"Japanese journal of pharmacology"},{"date":"1997 Dec","pmid":"9503394","title":"[Effect of F-1394, a potent and selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), on esterification of cholesterol and basolateral secretion of cholesteryl ester in Caco-2 cells].","journal":"Nihon yakurigaku zasshi. Folia pharmacologica Japonica"},{"date":"1996 Apr","pmid":"8624784","title":"Acyl-coenzyme A:cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase.","journal":"Arteriosclerosis, thrombosis, and vascular biology"},{"date":"1995 Sep","pmid":"8847832","title":"Hypocholesterolemic action and prevention of cholesterol absorption via the gut by F-1394, a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, in cholesterol diet-fed rats.","journal":"Japanese journal of pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dl-Alpha-Methylbenzyl Linoleamide, also known as AC-223, ARTES, MELINAMIDA, or MELINAMIDE, is a small molecule. Its exact mechanism and indications are not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}