{"id":"melatonin2-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL2109015","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Melatonin functions as a potent antioxidant that neutralizes reactive oxygen species and reduces oxidative stress in skin tissue. When applied topically as a 2% gel, it may promote tissue repair, reduce inflammation, and protect against UV-induced damage. The mechanism leverages melatonin's natural antioxidant properties to support dermatological healing and skin health.","oneSentence":"Melatonin is a topical gel formulation that acts as a free radical scavenger and antioxidant to protect skin and promote wound healing.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:54:15.706Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue repair"},{"name":"Skin protection and antioxidant therapy"}]},"trialDetails":[{"nctId":"NCT05759416","phase":"PHASE4","title":"Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2020-04-01","conditions":"Chronic Periodontitis","enrollment":40},{"nctId":"NCT04424875","phase":"PHASE3","title":"The Effect of Melatonin Application Following Removal of Impacted Third Molar","status":"COMPLETED","sponsor":"Fayoum University","startDate":"2020-07-01","conditions":"Impacted Third Molar Tooth","enrollment":38}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["intra- pocket Melatonin gel"],"phase":"marketed","status":"active","brandName":"Melatonin2%gel","genericName":"Melatonin2%gel","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melatonin is a topical gel formulation that acts as a free radical scavenger and antioxidant to protect skin and promote wound healing. Used for Wound healing and tissue repair, Skin protection and antioxidant therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}