{"id":"melatonin-pr","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"402f5b05-c71e-4dba-bc2b-049aee42952a","title":"HP AXIS (ARGENTUM NITRICUM, BERBERIS VULGARIS, IODIUM, KALI CARBONICUM, NATRUM MURIATICUM, ADRENALINUM, CORTISONE ACETICUM, DHEA, GLANDULA SUPRARENALIS SUIS, HYPOPHYSIS SUIS, HYPOTHALAMUS SUIS, MELATONIN, TESTOSTERONE, ARSENICUM ALBUM, PHOSPHORUS, PROTEUS (VULGARIS), SEPIA, SILICEA, ALLOXANUM, CORTICOTROPIN RELEASING HORMONE, ADRENOCORTICOTROPHIN, ALDOSTERONE) LIQUID [DESERET BIOLOGICALS, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Melatonin is an endogenous hormone produced by the pineal gland that regulates the sleep-wake cycle by acting on MT1 and MT2 melatonin receptors in the suprachiasmatic nucleus. The prolonged-release (PR) formulation extends melatonin availability throughout the night to maintain circadian rhythm regulation and improve sleep maintenance. This mechanism helps restore normal sleep patterns in patients with circadian rhythm disorders or insomnia.","oneSentence":"Melatonin PR is a prolonged-release formulation of melatonin that binds to melatonin receptors to regulate circadian rhythm and promote sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:00:14.298Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia"},{"name":"Circadian rhythm sleep disorders"}]},"trialDetails":[{"nctId":"NCT02789592","phase":"PHASE2","title":"Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2016-07","conditions":"REM Sleep Behavior Disorder, Parkinson Disease","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Circadin","Placebo tablet of Melatonin PR"],"phase":"marketed","status":"active","brandName":"Melatonin PR","genericName":"Melatonin PR","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melatonin PR is a prolonged-release formulation of melatonin that binds to melatonin receptors to regulate circadian rhythm and promote sleep. Used for Insomnia, Circadian rhythm sleep disorders.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}