{"id":"meladrazine","rwe":[{"pmid":"41813359","year":"2026","title":"An on-tissue parallel d(0)/d(20)-meladrazine derivatization approach for fatty acid peroxidation products imaging in adult zebrafish.","finding":"","journal":"Analytica chimica acta","studyType":"Clinical Study"},{"pmid":"27439567","year":"2016","title":"A procedure for the analysis of site-specific and structure-specific fucosylation in alpha-1-antitrypsin.","finding":"","journal":"Electrophoresis","studyType":"Clinical Study"},{"pmid":"26503433","year":"2015","title":"ESI-LC-MS Method for Haptoglobin Fucosylation Analysis in Hepatocellular Carcinoma and Liver Cirrhosis.","finding":"","journal":"Journal of proteome research","studyType":"Clinical Study"},{"pmid":"19160231","year":"2009","title":"Anticholinergics for urinary symptoms in multiple sclerosis.","finding":"","journal":"The Cochrane database of systematic reviews","studyType":"Clinical Study"},{"pmid":"3880780","year":"1985","title":"The effects of terodiline and meladrazine on severe motor urge incontinence in geriatric patients.","finding":"","journal":"Journal of the American Geriatrics Society","studyType":"Clinical Study"}],"tags":[{"label":"meladrazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G04BD03","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hydramitrazine","offLabel":[],"synonyms":["meladrazine tartrate","hydramitrazine","meladrazine"],"timeline":[],"approvals":[],"brandName":"Hydramitrazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"meladrazine","explanation":"Imagine your body's cells are like a city with many different roads and intersections. Hydramitrazine is like a traffic controller that tries to regulate the flow of traffic, but we don't know exactly how it does it or which roads it's controlling. This means we don't fully understand how it affects the body or what potential side effects it might have.","oneSentence":"Hydramitrazine is thought to work by interacting with biological pathways, but the exact mechanism is unknown.","technicalDetail":"The exact mechanism of action of hydramitrazine is unknown, but it is believed to interact with certain biological pathways, potentially affecting neurotransmitter release or receptor function."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3756","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MELADRAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:17:55.063879","biosimilars":[],"competitors":[{"drugName":"flavoxate","drugSlug":"flavoxate","fdaApproval":"1970-01-15","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxybutynin","drugSlug":"oxybutynin","fdaApproval":"1975-07-16","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tolterodine","drugSlug":"tolterodine","fdaApproval":"1998-03-25","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"solifenacin","drugSlug":"solifenacin","fdaApproval":"2004-11-19","patentExpiry":"May 18, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"trospium","drugSlug":"trospium","fdaApproval":"2004-05-28","genericCount":11,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"darifenacin","drugSlug":"darifenacin","fdaApproval":"2004-12-22","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fesoterodine","drugSlug":"fesoterodine","fdaApproval":"2008-10-31","patentExpiry":"Jun 7, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"mirabegron","drugSlug":"mirabegron","fdaApproval":"2012-06-28","patentExpiry":"Sep 30, 2036","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"meladrazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"flavoxate","brandName":"flavoxate","genericName":"flavoxate","approvalYear":"1970","relationship":"same-class"},{"drugId":"oxybutynin","brandName":"oxybutynin","genericName":"oxybutynin","approvalYear":"1975","relationship":"same-class"},{"drugId":"tolterodine","brandName":"tolterodine","genericName":"tolterodine","approvalYear":"1998","relationship":"same-class"},{"drugId":"solifenacin","brandName":"solifenacin","genericName":"solifenacin","approvalYear":"2004","relationship":"same-class"},{"drugId":"trospium","brandName":"trospium","genericName":"trospium","approvalYear":"2004","relationship":"same-class"},{"drugId":"darifenacin","brandName":"darifenacin","genericName":"darifenacin","approvalYear":"2004","relationship":"same-class"},{"drugId":"fesoterodine","brandName":"fesoterodine","genericName":"fesoterodine","approvalYear":"2008","relationship":"same-class"},{"drugId":"mirabegron","brandName":"mirabegron","genericName":"mirabegron","approvalYear":"2012","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"2V6Z0JG2X0","CHEBI":"CHEBI:135034","INN_ID":"1798","UMLSCUI":"C0065895","ChEMBL_ID":"CHEMBL2105242","KEGG_DRUG":"D07225","DRUGBANK_ID":"DB13272","PUBCHEM_CID":"71679","SECONDARY_CAS_RN":"20423-87-4","MESH_SUPPLEMENTAL_RECORD_UI":"C005040"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"G04BD03","allCodes":["G04BD03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 May 8","pmid":"41813359","title":"An on-tissue parallel d(0)/d(20)-meladrazine derivatization approach for fatty acid peroxidation products imaging in adult zebrafish.","journal":"Analytica chimica acta"},{"date":"2016 Oct","pmid":"27439567","title":"A procedure for the analysis of site-specific and structure-specific fucosylation in alpha-1-antitrypsin.","journal":"Electrophoresis"},{"date":"2015 Dec 4","pmid":"26503433","title":"ESI-LC-MS Method for Haptoglobin Fucosylation Analysis in Hepatocellular Carcinoma and Liver Cirrhosis.","journal":"Journal of proteome research"},{"date":"2009 Jan 21","pmid":"19160231","title":"Anticholinergics for urinary symptoms in multiple sclerosis.","journal":"The Cochrane database of systematic reviews"},{"date":"1985 Jan","pmid":"3880780","title":"The effects of terodiline and meladrazine on severe motor urge incontinence in geriatric patients.","journal":"Journal of the American Geriatrics Society"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydramitrazine is a small molecule with the synonyms BA 13155 FREE BASE, BA-13155 FREE BASE, HYDRAMITRAZINE, MELADRAZINA, MELADRAZINE, and MELADRAZINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}