{"id":"megestrol-yining","safety":{"commonSideEffects":[{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Thromboembolic events"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Adrenal insufficiency"},{"rate":null,"effect":"Vaginal bleeding"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Megestrol acetate binds to progesterone receptors, stimulating appetite and increasing caloric intake while promoting fat deposition. In oncology, it functions as a hormonal agent that can inhibit growth of hormone-responsive tumors, particularly in breast and endometrial cancers. The drug is commonly used to manage cancer-related cachexia and anorexia in advanced malignancies.","oneSentence":"Megestrol acetate is a progestin that acts as a progesterone receptor agonist to suppress appetite and promote weight gain, and also has anti-tumor effects in hormone-responsive cancers.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:35.133Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer-related cachexia and anorexia in advanced malignancies"},{"name":"Hormone-responsive breast cancer"},{"name":"Endometrial cancer"}]},"trialDetails":[{"nctId":"NCT02644408","phase":"PHASE3","title":"Megestrol Acetate for the Improvement of Quality of Life in Esophageal Cancer With Chemoradiotherapy","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Henan University of Science and Technology","startDate":"2014-10-01","conditions":"Stage III Esophageal Squamous Cell Carcinoma, Stage II Esophageal Squamous Cell Carcinoma","enrollment":184}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Yining"],"phase":"phase_3","status":"active","brandName":"Megestrol（Yining）","genericName":"Megestrol（Yining）","companyName":"The First Affiliated Hospital of Henan University of Science and Technology","companyId":"the-first-affiliated-hospital-of-henan-university-of-science-and-technology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Megestrol acetate is a progestin that acts as a progesterone receptor agonist to suppress appetite and promote weight gain, and also has anti-tumor effects in hormone-responsive cancers. Used for Cancer-related cachexia and anorexia in advanced malignancies, Hormone-responsive breast cancer, Endometrial cancer.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}