{"id":"mefruside","rwe":[],"tags":[{"label":"mefruside","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03BA05","category":"atc"},{"label":"Active","category":"status"},{"label":"Diuretics","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mefrusid","offLabel":[],"synonyms":["mefruside","mefrusid"],"timeline":[],"approvals":[],"brandName":"Mefrusid","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mefruside","explanation":"Think of the sodium-potassium ATPase pump like a gatekeeper that helps regulate the balance of sodium and potassium in the body. When this pump is working properly, it helps remove excess sodium from the body and maintain healthy blood pressure. Mefruside blocks this pump, which can help reduce blood pressure in people with hypertension.","oneSentence":"Mefruside works by inhibiting the sodium-potassium ATPase pump in the kidneys.","technicalDetail":"Mefruside acts as a competitive inhibitor of the sodium-potassium ATPase pump, specifically binding to the extracellular sodium site and reducing the pump's ability to exchange sodium ions for potassium ions, leading to increased sodium retention and decreased potassium excretion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1666","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEFRUSIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:01:30.204523","biosimilars":[],"competitors":[{"drugName":"quinethazone","drugSlug":"quinethazone","fdaApproval":"1963-04-10","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"indapamide","drugSlug":"indapamide","fdaApproval":"1983-07-06","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"mefruside","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"quinethazone","brandName":"quinethazone","genericName":"quinethazone","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"indapamide","brandName":"indapamide","genericName":"indapamide","approvalYear":"1983","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166872","NDDF":"004000","UNII":"X1NS9SNS92","CHEBI":"CHEBI:31809","INN_ID":"2153","RXNORM":"6696","UMLSCUI":"C0025156","ChEMBL_ID":"CHEMBL2105131","KEGG_DRUG":"D01877","DRUGBANK_ID":"DB13405","PUBCHEM_CID":"4047","SNOMEDCT_US":"317957004","MESH_DESCRIPTOR_UI":"D008529"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":75,"therapeuticAreas":["Nephrology"],"atcClassification":{"source":"DrugCentral","atcCode":"C03BA05","allCodes":["C03BA05","C03BB05"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mefruside is a small molecule. It is also known by the synonyms BAY 1500, BAY-1500, BAYCARON, MEFRUSIDA, and MEFRUSIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}