{"id":"mefexamide","rwe":[{"pmid":"7140947","year":"1982","title":"[Further study and the comparative characteristics of potential stimulants of higher nervous activity].","finding":"","journal":"Farmakologiia i toksikologiia","studyType":"Clinical Study"},{"pmid":"7128785","year":"1982","title":"[Use of the conditioned avoidance reflex for detecting potential stimulants of higher nervous activity and their comparative characteristics].","finding":"","journal":"Farmakologiia i toksikologiia","studyType":"Clinical Study"},{"pmid":"7340287","year":"1981","title":"[Quantitative determination of mefexamide and its main degradation product desmethyl-mefexamide in human urine after ingestion of therapeutic doses (author's transl)].","finding":"","journal":"Zeitschrift fur Rechtsmedizin. Journal of legal medicine","studyType":"Clinical Study"},{"pmid":"7303940","year":"1981","title":"[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].","finding":"","journal":"Zeitschrift fur Rechtsmedizin. Journal of legal medicine","studyType":"Clinical Study"},{"pmid":"333568","year":"1977","title":"[Clinical and experimental experiences with maprotiline, clomipramine, sydnocarb and mefexamide in mentally-ill patients and in healthy persons].","finding":"","journal":"Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"timodyne","offLabel":[],"synonyms":["mefexamide monohydrochloride","mefaxamid","mefexamide","timodyne","mephexamide","mexephenamide","mefessamide","mefexamide hydrochloride","mefexamide HCl"],"timeline":[],"approvals":[],"brandName":"Timodyne","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Unfortunately, the exact mechanism of action of Timodyne is not well understood, and more research is needed to determine how it produces its effects. In general, small molecule drugs like Timodyne are designed to bind to specific proteins or receptors in the body, which can alter the way that cells function and communicate with each other. This can lead to changes in various physiological processes, such as the regulation of chemical signals or the contraction of muscles.","oneSentence":"Timodyne works by interacting with a specific target in the body to produce a therapeutic effect.","technicalDetail":"As a small molecule drug, Timodyne is likely to exert its effects through a reversible, non-covalent interaction with a specific protein or receptor, potentially altering its activity or expression. The exact molecular details of this interaction are not yet known, and further research is needed to elucidate the pharmacological properties of Timodyne."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3769","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEFEXAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:17:25.207343","biosimilars":[],"competitors":[],"genericName":"mefexamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"84FP054Z2Q","CHEBI":"CHEBI:92373","INN_ID":"1637","UMLSCUI":"C0065871","ChEMBL_ID":"CHEMBL1368380","KEGG_DRUG":"D04894","PUBCHEM_CID":"4045","SECONDARY_CAS_RN":"3413-64-7","MESH_SUPPLEMENTAL_RECORD_UI":"C100080"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1982 Sep-Oct","pmid":"7140947","title":"[Further study and the comparative characteristics of potential stimulants of higher nervous activity].","journal":"Farmakologiia i toksikologiia"},{"date":"1982 Jul-Aug","pmid":"7128785","title":"[Use of the conditioned avoidance reflex for detecting potential stimulants of higher nervous activity and their comparative characteristics].","journal":"Farmakologiia i toksikologiia"},{"date":"1981","pmid":"7340287","title":"[Quantitative determination of mefexamide and its main degradation product desmethyl-mefexamide in human urine after ingestion of therapeutic doses (author's transl)].","journal":"Zeitschrift fur Rechtsmedizin. Journal of legal medicine"},{"date":"1981","pmid":"7303940","title":"[Contribution to biotransformation and analysis of the psychopharmacon mefexamide (author's transl)].","journal":"Zeitschrift fur Rechtsmedizin. Journal of legal medicine"},{"date":"1977","pmid":"333568","title":"[Clinical and experimental experiences with maprotiline, clomipramine, sydnocarb and mefexamide in mentally-ill patients and in healthy persons].","journal":"Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Timodyne (MEFEXAMIDE) is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it has not been approved by the FDA for any indications. Further information on its pharmacokinetics, safety, and efficacy is not available. As a result, it is not possible to provide a comprehensive summary of this drug. More research is needed to understand its potential uses and risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}