{"id":"medrylamine","rwe":[{"pmid":"2902103","year":"1988","title":"Screening procedure for the detection of alkanolamine antihistamines and their metabolites in urine using computerized gas chromatography-mass spectrometry.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"postafen","offLabel":[],"synonyms":["medrylamine","histaphene","histaphen","postafen"],"timeline":[],"approvals":[],"brandName":"Postafen","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of it like a key fitting into a lock. Postafen is like the key, and the lock is a specific protein or receptor in the body. When the key fits into the lock, it can either turn the lock (activating the protein) or block the lock (inhibiting the protein), which can help to treat a particular disease or condition.","oneSentence":"Postafen works by binding to and modulating the activity of specific proteins or receptors in the body.","technicalDetail":"Postafen is a small molecule that likely interacts with its target through non-covalent binding, potentially altering the protein's conformation or activity, and thereby producing its therapeutic effect."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Meclizine","title":"Meclizine","extract":"Meclizine, sold under the brand name Bonine, among others, is an antihistamine used to treat motion sickness and dizziness (vertigo). It is taken by mouth. Effects generally begin in an hour and last for up to a day.","wiki_society_and_culture":"== Society and culture ==\n=== Brand names ===\nMeclizine is an international nonproprietary name.\n\nIt is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine II (Less Drowsy Formulation). Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). In Canada, Antivert Tab was a combination of meclizine and nicotinic acid."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1661","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEDRYLAMINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Meclizine","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:17:19.426494","biosimilars":[],"competitors":[],"genericName":"medrylamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"5R003655CR","CHEBI":"CHEBI:135181","INN_ID":"4204","UMLSCUI":"C2698036","ChEMBL_ID":"CHEMBL2104714","PUBCHEM_CID":"10669"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1988 Jun 24","pmid":"2902103","title":"Screening procedure for the detection of alkanolamine antihistamines and their metabolites in urine using computerized gas chromatography-mass spectrometry.","journal":"Journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Postafen is a small molecule medication. It is also known as Medrilamina or Medrylamine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}