{"id":"medroxalol","rwe":[{"pmid":"38493604","year":"2024","title":"Exploring the anti-gout potential of sunflower receptacles alkaloids: A computational and pharmacological analysis.","finding":"","journal":"Computers in biology and medicine","studyType":"Clinical Study"},{"pmid":"30149308","year":"2018","title":"Proposing novel TNFα direct inhibitor Scaffolds using fragment-docking based e-pharmacophore modeling and binary QSAR-based virtual screening protocols pipeline.","finding":"","journal":"Journal of molecular graphics & modelling","studyType":"Clinical Study"},{"pmid":"8104240","year":"1993","title":"Beta-blocking agents with vasodilator activity.","finding":"","journal":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension","studyType":"Clinical Study"},{"pmid":"7684671","year":"1993","title":"An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists.","finding":"","journal":"Drugs","studyType":"Clinical Study"},{"pmid":"1378133","year":"1992","title":"Beta-blocking agents with vasodilating action.","finding":"","journal":"Journal of cardiovascular pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"medroxalol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"ADRA1A","category":"gene"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic alpha-Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["medroxalol monohydrochloride","medroxalol","medroxalol hydrochloride","medroxalol HCl"],"offLabel":[],"synonyms":["medroxalol monohydrochloride","medroxalol","medroxalol hydrochloride","medroxalol HCl"],"timeline":[],"aiSummary":"Medroxalol is a small molecule drug that targets the beta-1 adrenergic receptor. It is classified as a medroxalol, but its commercial status is unknown. The exact indications for medroxalol are also unclear, but it is known to have a half-life of 11.0 hours and bioavailability of 38%. As a beta-1 adrenergic receptor antagonist, medroxalol works by blocking the effects of epinephrine, leading to decreased heart rate and blood pressure. Further information on its development, approval, and generic status is not available.","approvals":[],"ecosystem":[],"mechanism":{"target":"Alpha-1A adrenergic receptor, Beta-1 adrenergic receptor","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRA1A","source":"DrugCentral","target":"Alpha-1A adrenergic receptor","protein":"Alpha-1A adrenergic receptor"}],"modality":"Small Molecule","drugClass":"medroxalol","explanation":"Imagine your heart is like a racing car engine. The beta-1 adrenergic receptor is like the accelerator pedal. When it's stimulated, the engine (heart) speeds up. Medroxalol is like a brake that blocks the accelerator pedal, slowing down the engine and reducing the heart rate and blood pressure.","oneSentence":"Medroxalol blocks the beta-1 adrenergic receptor to decrease heart rate and blood pressure.","technicalDetail":"Medroxalol is a non-selective beta-adrenergic receptor antagonist that competitively inhibits the binding of epinephrine to the beta-1 adrenergic receptor, resulting in decreased heart rate and contractility, and vasodilation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1658","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEDROXALOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:06:11.666951","biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"arformoterol","drugSlug":"arformoterol","fdaApproval":"2006-10-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"medroxalol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"arbutamine","brandName":"arbutamine","genericName":"arbutamine","approvalYear":"1997","relationship":"same-target"},{"drugId":"arformoterol","brandName":"arformoterol","genericName":"arformoterol","approvalYear":"2006","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-target"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"7PX96289JA","CHEBI":"CHEBI:135571","INN_ID":"4784","UMLSCUI":"C0065863","ChEMBL_ID":"CHEMBL1203104","KEGG_DRUG":"D04888","PUBCHEM_CID":"41835","SECONDARY_CAS_RN":"70161-10-3","MESH_SUPPLEMENTAL_RECORD_UI":"C024892"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"11.0 hours","clearance":"16.0 mL/min/kg","bioavailability":"38%","volumeOfDistribution":"7.9 L/kg"},"publicationCount":40,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Apr","pmid":"38493604","title":"Exploring the anti-gout potential of sunflower receptacles alkaloids: A computational and pharmacological analysis.","journal":"Computers in biology and medicine"},{"date":"2018 Oct","pmid":"30149308","title":"Proposing novel TNFα direct inhibitor Scaffolds using fragment-docking based e-pharmacophore modeling and binary QSAR-based virtual screening protocols pipeline.","journal":"Journal of molecular graphics & modelling"},{"date":"1993 Jun","pmid":"8104240","title":"Beta-blocking agents with vasodilator activity.","journal":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension"},{"date":"1993 Apr","pmid":"7684671","title":"An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists.","journal":"Drugs"},{"date":"1992","pmid":"1378133","title":"Beta-blocking agents with vasodilating action.","journal":"Journal of cardiovascular pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"MEDROXALOL","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}