{"id":"medrogestone","rwe":[{"pmid":"41732194","year":"2026","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","finding":"","journal":"EClinicalMedicine","studyType":"Clinical Study"},{"pmid":"40381587","year":"2025","title":"Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk.","finding":"","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia","studyType":"Clinical Study"},{"pmid":"40353175","year":"2025","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","finding":"","journal":"Surgical neurology international","studyType":"Clinical Study"},{"pmid":"38537944","year":"2024","title":"Use of progestogens and the risk of intracranial meningioma: national case-control study.","finding":"","journal":"BMJ (Clinical research ed.)","studyType":"Clinical Study"},{"pmid":"31367290","year":"2018","title":"The cost-effective, but forgotten, medical endometriosis therapy: a prospective, quasi-randomized study on progestin therapy.","finding":"","journal":"Facts, views & vision in ObGyn","studyType":"Clinical Study"}],"tags":[{"label":"medrogestone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03DB03","category":"atc"},{"label":"Active","category":"status"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Hormonal","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metrogestone","offLabel":[],"synonyms":["medrogestone","medrogesterone","metrogestone"],"timeline":[],"approvals":[],"brandName":"Metrogestone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"medrogestone","explanation":"Think of it like a key fitting into a lock. Metrogestone is a key that fits into a receptor in our cells, which then triggers a response that helps to reduce inflammation and suppress the immune system. This can be helpful in treating conditions where the immune system is overactive, but it can also have side effects if not used carefully.","oneSentence":"Metrogestone works by binding to and activating the glucocorticoid receptor, mimicking the effects of cortisol in the body.","technicalDetail":"Metrogestone exerts its effects by binding to the glucocorticoid receptor (GR), a transcription factor that regulates the expression of genes involved in inflammation and immune response. Upon binding, Metrogestone activates the GR, leading to the suppression of pro-inflammatory genes and the induction of anti-inflammatory genes, resulting in a reduction of inflammation and immune response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1657","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEDROGESTONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:32:00.432557","biosimilars":[],"competitors":[{"drugName":"dydrogesterone","drugSlug":"dydrogesterone","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dienogest","drugSlug":"dienogest","fdaApproval":"2010-05-06","relationship":"same-class"}],"genericName":"medrogestone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dydrogesterone","brandName":"dydrogesterone","genericName":"dydrogesterone","approvalYear":"","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"dienogest","brandName":"dienogest","genericName":"dienogest","approvalYear":"2010","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167427","NDDF":"003869","UNII":"077DN93G5B","CHEBI":"CHEBI:135446","INN_ID":"1852","RXNORM":"6690","UMLSCUI":"C0025145","ChEMBL_ID":"CHEMBL2106825","KEGG_DRUG":"D04885","DRUGBANK_ID":"DB09124","PUBCHEM_CID":"9949848","SNOMEDCT_US":"769098005","MESH_DESCRIPTOR_UI":"D008524"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":100,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DB03","allCodes":["G03DB03","G03FB07"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41732194","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","journal":"EClinicalMedicine"},{"date":"2025 Jul","pmid":"40381587","title":"Disproportionality analysis of progestogens and estrogens demonstrates increased meningioma risk.","journal":"Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia"},{"date":"2025","pmid":"40353175","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","journal":"Surgical neurology international"},{"date":"2024 Mar 27","pmid":"38537944","title":"Use of progestogens and the risk of intracranial meningioma: national case-control study.","journal":"BMJ (Clinical research ed.)"},{"date":"2018 Dec","pmid":"31367290","title":"The cost-effective, but forgotten, medical endometriosis therapy: a prospective, quasi-randomized study on progestin therapy.","journal":"Facts, views & vision in ObGyn"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metrogestone is a small molecule medication with the synonyms AY-13615, AY-13615S, AY 62022, AY-62022, COLPRO, and COLPRONE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}