{"id":"medium-itraconazole-tablet","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Nausea"},{"rate":"5-10","effect":"Abdominal pain"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"3-5","effect":"Headache"},{"rate":"2-5","effect":"Rash"},{"rate":"1-3","effect":"Hypokalemia"},{"rate":"1-2","effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Itraconazole is a triazole antifungal that selectively binds to fungal CYP51 enzyme, blocking the conversion of lanosterol to ergosterol, a critical sterol component of fungal cell membranes. This disruption leads to increased membrane permeability and fungal cell death. The drug has broad-spectrum activity against many fungal pathogens including Candida, Aspergillus, and dermatophytes.","oneSentence":"Itraconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis and compromising fungal cell membrane integrity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:16.767Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Blastomycosis"},{"name":"Histoplasmosis"},{"name":"Aspergillosis"},{"name":"Onychomycosis (fungal nail infection)"},{"name":"Oropharyngeal and esophageal candidiasis"}]},"trialDetails":[{"nctId":"NCT04035187","phase":"PHASE4","title":"Itraconazole Oral Absorption","status":"COMPLETED","sponsor":"University of Maryland, Baltimore","startDate":"2020-02-10","conditions":"Fungal Infection","enrollment":17}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["medium dissolving itraconazole tablet"],"phase":"marketed","status":"active","brandName":"medium itraconazole tablet","genericName":"medium itraconazole tablet","companyName":"University of Maryland, Baltimore","companyId":"university-of-maryland-baltimore","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Itraconazole inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis and compromising fungal cell membrane integrity. Used for Blastomycosis, Histoplasmosis, Aspergillosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}