{"id":"medazepam","rwe":[{"pmid":"38278133","year":"2024","title":"3D-printed extraction devices fabricated from silica particles suspended in acrylate resin.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"},{"pmid":"37830174","year":"2024","title":"Dispersive liquid-liquid microextraction (DLLME) for determination of tricyclic antidepressants in whole blood and plasma samples and analysis by liquid chromatography with diode array detector (LC-DAD).","finding":"","journal":"Toxicology mechanisms and methods","studyType":"Clinical Study"},{"pmid":"34038545","year":"2021","title":"Driving Performance Under Treatment of Most Frequently Prescribed Drugs for Mental Disorders: A Systematic Review of Patient Studies.","finding":"","journal":"The international journal of neuropsychopharmacology","studyType":"Clinical Study"},{"pmid":"33295819","year":"2020","title":"Examination of the effect of air atmosphere on heterogeneous reactions under surface ionization of psychotropic drug molecules.","finding":"","journal":"European journal of mass spectrometry (Chichester, England)","studyType":"Clinical Study"},{"pmid":"28903606","year":"2017","title":"Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects.","finding":"","journal":"Drug metabolism reviews","studyType":"Clinical Study"}],"tags":[{"label":"medazepam","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Anxiety Agents","category":"pharmacology"},{"label":"Anticonvulsants","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"GABA Agents","category":"pharmacology"},{"label":"GABA Modulators","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"},{"label":"Muscle Relaxants, Central","category":"pharmacology"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"},{"label":"Tranquilizing Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mezapam","offLabel":[],"synonyms":["medazepam","mezapam","medazepam hydrochloride","medazepam HCl"],"timeline":[],"aiSummary":"Medazepam, a small molecule belonging to the drug class of benzodiazepines, is a medication with unknown target and commercial status. Its exact mechanism of action is not well-documented, but it is believed to work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative, anxiolytic, and muscle relaxant effects. Medazepam is used to treat anxiety and muscle spasms, but its approved indications and pharmacokinetic properties are unknown. As a benzodiazepine, medazepam carries a risk of dependence and withdrawal symptoms, and its use should be carefully monitored. Further research is needed to fully understand the properties and effects of medazepam.","approvals":[],"brandName":"Mezapam","ecosystem":[],"mechanism":{"target":"GABA-A receptor; anion channel","modality":"Small Molecule","drugClass":"medazepam","explanation":"Imagine your brain is like a busy city, with lots of signals and activity going on. GABA is like a traffic cop that helps slow down the traffic and keep things calm. Medazepam helps GABA do its job more effectively, which can lead to feelings of relaxation and reduced anxiety.","oneSentence":"Medazepam works by enhancing the calming effect of a neurotransmitter called GABA in the brain.","technicalDetail":"Medazepam acts as a positive allosteric modulator of the GABA_A receptor, increasing the frequency of chloride channel opening and resulting in hyperpolarization of the neuronal membrane, which leads to a decrease in neuronal excitability and anxiolytic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1654","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MEDAZEPAM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEDAZEPAM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:31:52.928967","biosimilars":[],"competitors":[{"drugName":"diazepam","drugSlug":"diazepam","fdaApproval":"1963-11-15","patentExpiry":"Oct 16, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlordiazepoxide","drugSlug":"chlordiazepoxide","fdaApproval":"1960-02-24","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"oxazepam","drugSlug":"oxazepam","fdaApproval":"1965-06-04","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clorazepate","drugSlug":"clorazepate","fdaApproval":"1972-06-23","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"lorazepam","drugSlug":"lorazepam","fdaApproval":"1977-09-30","patentExpiry":"Jan 8, 2034","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clobazam","drugSlug":"clobazam","fdaApproval":"2011-10-21","patentExpiry":"Sep 5, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"prazepam","drugSlug":"prazepam","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"alprazolam","drugSlug":"alprazolam","fdaApproval":"1981-10-16","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"halazepam","drugSlug":"halazepam","fdaApproval":"1981-09-24","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"medazepam","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"diazepam","brandName":"diazepam","genericName":"diazepam","approvalYear":"1963","relationship":"same-class"},{"drugId":"chlordiazepoxide","brandName":"chlordiazepoxide","genericName":"chlordiazepoxide","approvalYear":"1960","relationship":"same-class"},{"drugId":"oxazepam","brandName":"oxazepam","genericName":"oxazepam","approvalYear":"1965","relationship":"same-class"},{"drugId":"clorazepate","brandName":"clorazepate","genericName":"clorazepate","approvalYear":"1972","relationship":"same-class"},{"drugId":"lorazepam","brandName":"lorazepam","genericName":"lorazepam","approvalYear":"1977","relationship":"same-class"},{"drugId":"clobazam","brandName":"clobazam","genericName":"clobazam","approvalYear":"2011","relationship":"same-class"},{"drugId":"prazepam","brandName":"prazepam","genericName":"prazepam","approvalYear":"","relationship":"same-class"},{"drugId":"alprazolam","brandName":"alprazolam","genericName":"alprazolam","approvalYear":"1981","relationship":"same-class"},{"drugId":"halazepam","brandName":"halazepam","genericName":"halazepam","approvalYear":"1981","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT04807101","phase":"EARLY_PHASE1","title":"Sedation Regimens in GI Endoscopy","status":"COMPLETED","sponsor":"Greg S Cohen MD LLC","startDate":"2021-04-05","conditions":["Anesthesia","Endoscopy","Colonoscopy","Conscious Sedation"],"enrollment":300,"completionDate":"2023-07-10"},{"nctId":"NCT01984931","phase":"PHASE3","title":"Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting","status":"UNKNOWN","sponsor":"CM Chungmu Hospital","startDate":"2013-10","conditions":["Nausea","Vomiting"],"enrollment":45,"completionDate":"2013-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000166925","NDDF":"004101","UNII":"P0J3387W3S","CHEBI":"CHEBI:31807","INN_ID":"2517","RXNORM":"6680","UMLSCUI":"C0025051","ChEMBL_ID":"CHEMBL28333","KEGG_DRUG":"D01292","DRUGBANK_ID":"DB13437","PUBCHEM_CID":"4041","SNOMEDCT_US":"35967000","SECONDARY_CAS_RN":"2898-11-5","MESH_DESCRIPTOR_UI":"D008472"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":220,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BA03","allCodes":["N05BA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Feb 22","pmid":"38278133","title":"3D-printed extraction devices fabricated from silica particles suspended in acrylate resin.","journal":"Journal of chromatography. A"},{"date":"2024 Feb","pmid":"37830174","title":"Dispersive liquid-liquid microextraction (DLLME) for determination of tricyclic antidepressants in whole blood and plasma samples and analysis by liquid chromatography with diode array detector (LC-DAD).","journal":"Toxicology mechanisms and methods"},{"date":"2021 Sep 21","pmid":"34038545","title":"Driving Performance Under Treatment of Most Frequently Prescribed Drugs for Mental Disorders: A Systematic Review of Patient Studies.","journal":"The international journal of neuropsychopharmacology"},{"date":"2020 Dec","pmid":"33295819","title":"Examination of the effect of air atmosphere on heterogeneous reactions under surface ionization of psychotropic drug molecules.","journal":"European journal of mass spectrometry (Chichester, England)"},{"date":"2017 Nov","pmid":"28903606","title":"Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects.","journal":"Drug metabolism reviews"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}