{"id":"mecysteine","rwe":[{"pmid":"37116204","year":"2023","title":"Exploring the Role of Amino Acid-Derived Multivariate Metal-Organic Frameworks as Catalysts in Hemiketalization Reactions.","finding":"","journal":"Inorganic chemistry","studyType":"Clinical Study"},{"pmid":"18832259","year":"2008","title":"Erdosteine for COPD exacerbations.","finding":"","journal":"Drug and therapeutics bulletin","studyType":"Clinical Study"},{"pmid":"7373852","year":"1980","title":"[Effects of cysteine compounds on antibiotics I. Effects of L-cysteine and its derivatives on the potency of antibiotics (author's transl)].","finding":"","journal":"The Japanese journal of antibiotics","studyType":"Clinical Study"}],"tags":[{"label":"mecysteine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Expectorants","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":["NCT03649750","NCT00829205","NCT00377403","NCT05100680","NCT01046136","NCT01497431","NCT07398924","NCT01537081","NCT02859246","NCT01381354","NCT00489372","NCT03633487","NCT04900129","NCT03642262","NCT04945096","NCT02259595","NCT01202279"],"aliases":[],"patents":[],"pricing":[],"allNames":"methyl cysteine","offLabel":[],"synonyms":["mecysteine hydrochloride","methyl cysteine","mecysteine","cysteine methyl ester","methyl cysteinate"],"timeline":[],"approvals":[],"brandName":"Methyl Cysteine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mecysteine","explanation":"Imagine cystine as a puzzle piece that can fit together to form a stone. Methyl cysteine acts like a puzzle piece that fits into the same spot, but it's slightly different, so the cystine pieces can't fit together to form a stone. This helps prevent the formation of cystine stones in the kidneys and urinary tract.","oneSentence":"Methyl cysteine works by binding to cystine and preventing its crystallization.","technicalDetail":"Methyl cysteine acts as a cystine-binding agent, inhibiting the formation of cystine crystals through a mechanism that is not fully understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1653","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MECYSTEINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:17:07.824048","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"mecysteine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT03649750","phase":"Phase 1","title":"A Phase I, Open-label, Single-dose, Randomized, 2-way Cross-over Study Designed to Examine the Relative Bioavailability of Guaifenesin When a Mucinex Extended Release 600 mg Bi-layer Tablet is Taken U","status":"COMPLETED","sponsor":"Reckitt Benckiser LLC","isPivotal":false,"enrollment":36,"indication":"Healthy Subjects","completionDate":"2013-08-07"},{"nctId":"NCT00829205","phase":"Phase 1","title":"A Phase I/II Study of Methylselenocysteine (MSC) in Combination With Immunochemotherapy (R-ICE) in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)","status":"WITHDRAWN","sponsor":"Cancer Research UK","isPivotal":false,"enrollment":0,"indication":"Lymphoma","completionDate":""},{"nctId":"NCT00377403","phase":"Phase 4","title":"Randomized Clinical Trial to Evaluate Guidelines for Acute Rhinosinusitis (Phase IV Study)","status":"COMPLETED","sponsor":"Washington University School of Medicine","isPivotal":false,"enrollment":172,"indication":"Acute Respiratory Infections, Acute Rhinosinusitis","completionDate":"2010-08"},{"nctId":"NCT05100680","phase":"NA","title":"Study of the Effect of 12-week Dietary Supplementation With a Multicomponent Nutritional Supplement on Nails and Skin: a Randomized, Double-blind Placebo-controlled Study","status":"COMPLETED","sponsor":"VIST - 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