{"id":"mecobalamin-im-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Itching or rash"},{"rate":null,"effect":"Hypokalemia (rare)"}]},"_chembl":{"chemblId":"CHEMBL2359370","moleculeType":"Small molecule","molecularWeight":"1344.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mecobalamin is a methylcobalamin derivative that acts as a cofactor for methionine synthase and other B12-dependent enzymes essential for DNA synthesis, myelin formation, and neuronal function. It crosses the blood-brain barrier more effectively than cyanocobalamin and is directly utilized in cellular metabolism without requiring enzymatic conversion. This makes it particularly effective for treating B12 deficiency-related neurological conditions.","oneSentence":"Mecobalamin is an active form of vitamin B12 that replenishes cellular cobalamin stores and restores normal methylation and energy metabolism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:17.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin B12 deficiency with neurological manifestations"},{"name":"Peripheral neuropathy associated with B12 deficiency"},{"name":"Subacute combined degeneration"},{"name":"Pernicious anemia with neurological complications"}]},"trialDetails":[{"nctId":"NCT03548311","phase":"PHASE3","title":"Clinical Trial of Ultra-high Dose Methylcobalamin for ALS","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2017-11-01","conditions":"Amyotrophic Lateral Sclerosis","enrollment":130},{"nctId":"NCT06400888","phase":"NA","title":"Needle-Free Subcutaneous Injector and Conventional Intramuscular Injection of Mecobalamin in Diabetes Peripheral Neuropathy","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2024-05-30","conditions":"Diabetic Peripheral Neuropathy","enrollment":30},{"nctId":"NCT00445172","phase":"PHASE2, PHASE3","title":"A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS)","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2008-02","conditions":"Amyotrophic Lateral Sclerosis (ALS)","enrollment":135},{"nctId":"NCT00444613","phase":"PHASE2, PHASE3","title":"A Study in Patients With Amyotrophic Lateral Sclerosis (ALS)","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2007-04","conditions":"Amyotrophic Lateral Sclerosis (ALS)","enrollment":373},{"nctId":"NCT01192113","phase":"PHASE4","title":"Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109)","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2010-04","conditions":"Peripheral Neuropathy","enrollment":1072}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Mecobalamin IM injection","genericName":"Mecobalamin IM injection","companyName":"Eisai Co., Ltd.","companyId":"eisai","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mecobalamin is a small molecule administered via intramuscular (IM) injection, used to treat conditions such as Diabetic Peripheral Neuropathy and Peripheral Neuropathy, as well as Amyotrophic Lateral Sclerosis (ALS).","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}