{"id":"mebendazole-polymorph-c","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mebendazole is a benzimidazole anthelmintic that binds to β-tubulin and prevents microtubule polymerization in nematodes and some cestodes. This disruption of the parasite's cytoskeletal structure leads to immobilization, reduced glucose uptake, and eventual death. Polymorph C represents a specific crystalline form of mebendazole, potentially optimized for improved bioavailability or efficacy.","oneSentence":"Mebendazole polymorph C inhibits microtubule assembly in parasitic worms by binding to β-tubulin, disrupting their motility and nutrient uptake.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:29.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helminthic infections (nematodes and cestodes)"},{"name":"Soil-transmitted helminth infections"}]},"trialDetails":[{"nctId":"NCT01350271","phase":"PHASE3","title":"Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections","status":"COMPLETED","sponsor":"University of Kelaniya","startDate":"2011-05","conditions":"Necator Americanus Infection","enrollment":214}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Lot FG10H01"],"phase":"phase_3","status":"active","brandName":"Mebendazole polymorph C","genericName":"Mebendazole polymorph C","companyName":"University of Kelaniya","companyId":"university-of-kelaniya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mebendazole polymorph C inhibits microtubule assembly in parasitic worms by binding to β-tubulin, disrupting their motility and nutrient uptake. Used for Helminthic infections (nematodes and cestodes), Soil-transmitted helminth infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}