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In anaphylaxis, these combined effects rapidly reverse airway obstruction, hypotension, and cardiovascular collapse.","oneSentence":"Epinephrine is a sympathomimetic amine that activates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and airway dilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:20:25.170Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anaphylaxis (acute allergic reaction)"},{"name":"Severe asthma exacerbation with bronchospasm"}]},"trialDetails":[{"nctId":"NCT03567473","phase":"PHASE3","title":"Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study","status":"COMPLETED","sponsor":"Children's Hospital of Eastern Ontario","startDate":"2018-12-13","conditions":"Bronchiolitis","enrollment":864},{"nctId":"NCT05819541","phase":"PHASE2","title":"Treating Exacerbations of Asthma With Oral Montelukast in Children","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2023-10-20","conditions":"Status Asthmaticus","enrollment":90},{"nctId":"NCT05363670","phase":"PHASE2","title":"Administration of ARS-1 or Albuterol in Subjects With Persistent Asthma","status":"COMPLETED","sponsor":"ARS Pharmaceuticals, Inc.","startDate":"2022-07-28","conditions":"Asthma","enrollment":18},{"nctId":"NCT02478398","phase":"PHASE3","title":"Efficacy and Safety Study of RAGWITEK™ (MK-3641) in Children With Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (MK-3641-008)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2015-07-20","conditions":"Rhinitis, Allergic, Seasonal","enrollment":1025},{"nctId":"NCT01143051","phase":"PHASE1, PHASE2","title":"Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy Volunteers","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2010-01","conditions":"Asthma","enrollment":24},{"nctId":"NCT01460511","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of E004 in Children With Asthma","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2011-10","conditions":"Asthma","enrollment":70},{"nctId":"NCT01025648","phase":"PHASE1, PHASE2","title":"Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients.","status":"TERMINATED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2009-12","conditions":"Asthma","enrollment":9},{"nctId":"NCT01188577","phase":"PHASE1, PHASE2","title":"Epinephrine Inhalation Aerosol USP, a HFA-MDI Study for Assessment of Pharmacokinetics","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2010-08","conditions":"Asthma, Bronchospasm, Wheezing","enrollment":23},{"nctId":"NCT01321827","phase":"PHASE2, PHASE3","title":"Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2011-04","conditions":"Allergic Bronchopulmonary Aspergillosis","enrollment":100},{"nctId":"NCT01737892","phase":"PHASE1, PHASE2","title":"Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults","status":"TERMINATED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2012-11","conditions":"Asthma","enrollment":21},{"nctId":"NCT01737905","phase":"PHASE3","title":"Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2012-10","conditions":"Asthma","enrollment":28},{"nctId":"NCT01357642","phase":"PHASE3","title":"Epinephrine Inhalation Aerosol USP: For Evaluation Of Efficacy And Safety In Asthma Patients","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2011-07","conditions":"Asthma","enrollment":373}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":10,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MDI Adrenaline"],"phase":"phase_3","status":"active","brandName":"MDI Epinephrine","genericName":"MDI Epinephrine","companyName":"Children's Hospital of Eastern Ontario","companyId":"children-s-hospital-of-eastern-ontario","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epinephrine is a sympathomimetic amine that activates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and airway dilation. Used for Anaphylaxis (acute allergic reaction), Severe asthma exacerbation with bronchospasm.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}