{"id":"mc-1-pyridoxal-5-phosphate","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral neuropathy (at high doses)"},{"rate":null,"effect":"Sensory ataxia (at high doses)"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PLP serves as an essential coenzyme for transaminases, decarboxylases, and other metabolic enzymes critical for protein metabolism and synthesis of neurotransmitters including serotonin, dopamine, and GABA. By supplementing PLP levels, the drug restores enzymatic function in conditions characterized by B6 deficiency or impaired homocysteine metabolism, potentially reducing cardiovascular and neurological complications.","oneSentence":"Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6 that acts as a cofactor for numerous enzymes involved in amino acid metabolism, neurotransmitter synthesis, and homocysteine metabolism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:23.168Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Homocysteinemia / Elevated homocysteine for cardiovascular risk reduction"},{"name":"Pyridoxine-dependent conditions"}]},"trialDetails":[{"nctId":"NCT03738943","phase":"EARLY_PHASE1","title":"Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults","status":"COMPLETED","sponsor":"Colorado State University","startDate":"2019-02-07","conditions":"Receptor Blockade","enrollment":9},{"nctId":"NCT00402506","phase":"PHASE3","title":"A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG","status":"COMPLETED","sponsor":"Medicure","startDate":"2006-11","conditions":"Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury","enrollment":3000},{"nctId":"NCT00157729","phase":"PHASE2","title":"MATCHED (MC-1 and ACE Therapeutic Combination for Hypertensive Diabetics)","status":"COMPLETED","sponsor":"Medicure","startDate":"2004-08","conditions":"Diabetes Mellitus Type 2, Hypertension, Metabolic Syndrome","enrollment":160},{"nctId":"NCT00157716","phase":"PHASE2","title":"MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)","status":"COMPLETED","sponsor":"Medicure","startDate":"2004-04","conditions":"Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury","enrollment":900}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"(MC-1) Pyridoxal 5'-phosphate","genericName":"(MC-1) Pyridoxal 5'-phosphate","companyName":"Medicure","companyId":"medicure","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6 that acts as a cofactor for numerous enzymes involved in amino acid metabolism, neurotransmitter synthesis, and homocysteine metabolism. Used for Homocysteinemia / Elevated homocysteine for cardiovascular risk reduction, Pyridoxine-dependent conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}