{"id":"mazaticol","rwe":[{"pmid":"11888334","year":"2002","title":"Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.","finding":"","journal":"Clinical pharmacokinetics","studyType":"Clinical Study"},{"pmid":"1589555","year":"1992","title":"[A computer-assisted EEG study on psychotropic properties of antiparkinsonian drugs].","finding":"","journal":"Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica","studyType":"Clinical Study"},{"pmid":"2236897","year":"1990","title":"Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.","finding":"","journal":"Research communications in chemical pathology and pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"mazaticol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N04AA10","category":"atc"},{"label":"Active","category":"status"},{"label":"Extrapyramidal sign","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pentona","offLabel":[],"synonyms":["mazaticol","mazaticol hydrochloride","mazaticol HCl","mazaticol hydrochloride monohydrate","pentona","mazaticol hydrochloride hydrate"],"timeline":[],"approvals":[],"brandName":"Pentona","ecosystem":[{"indication":"Extrapyramidal sign","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"mazaticol","explanation":"Imagine your brain is a complex network of messengers, called neurotransmitters, that help control your movements. In people with Extrapyramidal signs, these messengers can get out of balance, leading to abnormal movements. Pentona helps restore balance to these messengers, reducing the symptoms of the condition.","oneSentence":"Pentona works by modulating the activity of certain neurotransmitters in the brain.","technicalDetail":"Pentona exerts its effects by interacting with specific receptors in the brain, influencing the release and reuptake of dopamine and other neurotransmitters involved in motor control."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1639","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MAZATICOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:14:21.797493","biosimilars":[],"competitors":[{"drugName":"trihexyphenidyl","drugSlug":"trihexyphenidyl","fdaApproval":"1949-05-13","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"biperiden","drugSlug":"biperiden","fdaApproval":"1959-09-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"metixene","drugSlug":"metixene","fdaApproval":"","relationship":"same-class"},{"drugName":"procyclidine","drugSlug":"procyclidine","fdaApproval":"1955-07-27","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"profenamine","drugSlug":"profenamine","fdaApproval":"","relationship":"same-class"}],"genericName":"mazaticol","indications":{"approved":[{"name":"Extrapyramidal sign","source":"DrugCentral","snomedId":43378000,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"trihexyphenidyl","brandName":"trihexyphenidyl","genericName":"trihexyphenidyl","approvalYear":"1949","relationship":"same-class"},{"drugId":"biperiden","brandName":"biperiden","genericName":"biperiden","approvalYear":"1959","relationship":"same-class"},{"drugId":"metixene","brandName":"metixene","genericName":"metixene","approvalYear":"","relationship":"same-class"},{"drugId":"procyclidine","brandName":"procyclidine","genericName":"procyclidine","approvalYear":"1955","relationship":"same-class"},{"drugId":"profenamine","brandName":"profenamine","genericName":"profenamine","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"008201","UNII":"I6X824OGWZ","CHEBI":"CHEBI:31802","INN_ID":"3410","UMLSCUI":"C0065760","ChEMBL_ID":"CHEMBL2105187","KEGG_DRUG":"D08157","DRUGBANK_ID":"DB13448","PUBCHEM_CID":"118984411","SECONDARY_CAS_RN":"32891-29-5","MESH_SUPPLEMENTAL_RECORD_UI":"C003706"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N04AA10","allCodes":["N04AA10"]},"biosimilarFilings":[],"recentPublications":[{"date":"2002","pmid":"11888334","title":"Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients.","journal":"Clinical pharmacokinetics"},{"date":"1992","pmid":"1589555","title":"[A computer-assisted EEG study on psychotropic properties of antiparkinsonian drugs].","journal":"Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica"},{"date":"1990 Sep","pmid":"2236897","title":"Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.","journal":"Research communications in chemical pathology and pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pentona is a small molecule medication. It is also known by the synonyms KAO 264, KAO-264, MAZATICOL, MAZATICOL HYDROCHLORIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}