{"id":"matching-placebo-for-ibuprofen","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL521","moleculeType":"Small molecule","molecularWeight":"206.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"A matching placebo contains no active pharmaceutical ingredient and is used in blinded clinical trials to control for placebo effect and bias. It is formulated to be indistinguishable from the active ibuprofen comparator in appearance, taste, and administration route, allowing researchers to isolate the true therapeutic effect of ibuprofen from psychological and contextual factors.","oneSentence":"This is an inert placebo formulation designed to match the appearance and administration of ibuprofen for use as a control in clinical trials.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:42.933Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Control arm in phase 3 clinical trials for ibuprofen efficacy and safety"}]},"trialDetails":[{"nctId":"NCT06088732","phase":"PHASE1, PHASE2","title":"Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression","status":"RECRUITING","sponsor":"Laureate Institute for Brain Research, Inc.","startDate":"2024-03-12","conditions":"Bipolar Depression","enrollment":20},{"nctId":"NCT01670656","phase":"PHASE2","title":"A Study to Evaluate the Effect of Contraceptive Vaginal Rings on Primary Dysmenorrhea (P08257/MK-8175A/MK-8342B-057)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2013-01-21","conditions":"Dysmenorrhea","enrollment":439},{"nctId":"NCT03554018","phase":"PHASE3","title":"Ibuprofen With or Without Acetaminophen for Low Back Pain","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2018-10-16","conditions":"Low Back Pain","enrollment":120},{"nctId":"NCT00820027","phase":"PHASE3","title":"Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2008-12-15","conditions":"Pain, Postoperative","enrollment":776},{"nctId":"NCT00630929","phase":"PHASE4","title":"Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (Europe)","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-01","conditions":"Osteoarthritis, Knee","enrollment":388},{"nctId":"NCT00620867","phase":"PHASE4","title":"Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2002-10","conditions":"Osteoarthritis, Knee","enrollment":393},{"nctId":"NCT00640627","phase":"PHASE4","title":"Efficacy and Safety of Celecoxib Versus Placebo in the Treatment of Patients With Osteoarthritis of the Knee Who Were Unresponsive to Naproxen and Ibuprofen","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-12","conditions":"Osteoarthritis, Knee","enrollment":380},{"nctId":"NCT00638807","phase":"PHASE4","title":"Safety and Efficacy of Celecoxib Versus Placebo in the Treatment of Knee Osteoarthritis in Patients Who Were Unresponsive to Naproxen and Ibuprofen","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-12","conditions":"Osteoarthritis, Knee","enrollment":388},{"nctId":"NCT00640809","phase":"PHASE4","title":"Comparison of Small Bowel Lesions Associated With Celecoxib Versus Ibuprofen Plus Omeprazole","status":"COMPLETED","sponsor":"Pfizer's Upjohn has merged with Mylan to form Viatris Inc.","startDate":"2003-10","conditions":"Bowel Diseases, Inflammatory","enrollment":408},{"nctId":"NCT03080493","phase":"PHASE4","title":"Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2017-03-20","conditions":"Abortion, Induced, Cervical Preparation, Pain","enrollment":121},{"nctId":"NCT01435577","phase":"PHASE2","title":"Intravenous Tapentadol in Post-Bunionectomy Pain","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2011-09","conditions":"Bunion, Pain","enrollment":177},{"nctId":"NCT02573714","phase":"NA","title":"Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises","status":"UNKNOWN","sponsor":"Cameroon Baptist Convention Health","startDate":"2015-12","conditions":"Sickle Cell Disease","enrollment":160},{"nctId":"NCT02597634","phase":"PHASE3","title":"Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS)","status":"COMPLETED","sponsor":"Strategic Science & Technologies, LLC","startDate":"2015-11","conditions":"Delayed Onset Muscle Soreness, DOMS","enrollment":156},{"nctId":"NCT02339129","phase":"PHASE2","title":"Dosing Interval Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness","status":"COMPLETED","sponsor":"Strategic Science & Technologies, LLC","startDate":"2014-11","conditions":"Delayed Onset Muscle Soreness","enrollment":72},{"nctId":"NCT00880373","phase":"PHASE4","title":"Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine","status":"TERMINATED","sponsor":"London North West Healthcare NHS Trust","startDate":"2011-03","conditions":"Sickle Cell Disease","enrollment":320},{"nctId":"NCT00239746","phase":"PHASE1","title":"BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories","status":"UNKNOWN","sponsor":"National Institute on Aging (NIA)","startDate":"2005-10","conditions":"Alzheimer's Disease","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Matching Placebo for Ibuprofen","genericName":"Matching Placebo for Ibuprofen","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is an inert placebo formulation designed to match the appearance and administration of ibuprofen for use as a control in clinical trials. Used for Control arm in phase 3 clinical trials for ibuprofen efficacy and safety.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}