{"id":"marketed-varicella-vaccine-lot-1","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Injection site reactions (erythema, swelling, pain)"},{"rate":"10-15","effect":"Fever"},{"rate":"3-5","effect":"Varicella-like rash (vaccine strain)"},{"rate":"5-10","effect":"Myalgia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a live attenuated vaccine containing weakened varicella-zoster virus that replicates in the body at low levels, triggering both humoral (antibody) and cell-mediated immune responses. The immune system learns to recognize and respond to the virus without causing severe disease, providing long-term protection against natural varicella infection and reducing the risk of herpes zoster (shingles) later in life.","oneSentence":"The varicella vaccine stimulates the immune system to produce antibodies and cellular immunity against the varicella-zoster virus, preventing chickenpox infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:20:10.130Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of varicella (chickenpox) in children and adults"},{"name":"Prevention of herpes zoster (shingles) in immunocompetent individuals"}]},"trialDetails":[{"nctId":"NCT06740630","phase":"PHASE3","title":"A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age","status":"RECRUITING","sponsor":"GlaxoSmithKline","startDate":"2025-01-10","conditions":"Chickenpox","enrollment":1840}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Marketed varicella vaccine_Lot 1","genericName":"Marketed varicella vaccine_Lot 1","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"The varicella vaccine stimulates the immune system to produce antibodies and cellular immunity against the varicella-zoster virus, preventing chickenpox infection. Used for Prevention of varicella (chickenpox) in children and adults, Prevention of herpes zoster (shingles) in immunocompetent individuals.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}