{"id":"marcaine-0-25-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia, arrhythmias)"},{"rate":null,"effect":"Local reactions (pain at injection site)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2108251","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. The drug has a relatively long duration of action compared to other local anesthetics due to its high lipophilicity and protein binding.","oneSentence":"Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:52.269Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia"},{"name":"Pediatric anesthesia and pain management"}]},"trialDetails":[{"nctId":"NCT07458282","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane 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