{"id":"manuka-honey","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or stinging at wound site"},{"rate":null,"effect":"Allergic reaction (rare, in honey-sensitive individuals)"}]},"_chembl":{"chemblId":"CHEMBL2108391","moleculeType":"Unknown"},"_dailymed":{"setId":"b742585d-9a0c-489b-b268-590583cfabd1","title":"MANUKA HONEY EXTRA STRENGTH (ALLANTOIN) GEL [FIRST HONEY LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Manuka honey, derived from the nectar of Leptospermum scoparium flowers in New Zealand, contains elevated levels of methylglyoxal (MGO) and unique compounds like leptosperin that provide broad-spectrum antimicrobial activity against bacteria, fungi, and viruses. Beyond antimicrobial effects, it modulates inflammatory pathways, stimulates immune cell activity, and promotes angiogenesis and collagen deposition, facilitating tissue regeneration and wound closure.","oneSentence":"Manuka honey exerts antimicrobial and anti-inflammatory effects through its high methylglyoxal content and other bioactive compounds, promoting wound healing and tissue repair.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:15.496Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and management (acute and chronic wounds)"},{"name":"Burn treatment"},{"name":"Diabetic foot ulcers"},{"name":"Antimicrobial dressing for infected wounds"}]},"trialDetails":[{"nctId":"NCT06726876","phase":"PHASE3","title":"Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-10-01","conditions":"Periodontitis, 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Used for Wound healing and management, Burn treatment, Ulcer management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}