{"id":"mannosulfan","rwe":[{"pmid":"224835","year":"1979","title":"Influence of insulin on pharmacokinetics of mannosulfan in rats.","finding":"","journal":"Archivum immunologiae et therapiae experimentalis","studyType":"Clinical Study"},{"pmid":"349802","year":"1978","title":"Prolongation of rat cardiac allograft survival by donor pretreatment. Screening of antineoplastic drugs.","finding":"","journal":"Transplantation","studyType":"Clinical Study"},{"pmid":"181298","year":"1975","title":"Cytostatic treatment of polycythaemia rubra vera. Comparison of the effects of some cytostatics in 100 patients in a period of five years.","finding":"","journal":"Haematologia","studyType":"Clinical Study"}],"tags":[{"label":"mannosulfan","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"L01AB03","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["mannosulfan"],"offLabel":[],"synonyms":["mannosulfan"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mannosulfan","explanation":"Imagine your body's cells are like locks, and mannosulfan is a key that fits into one of those locks. When it binds to the lock, it can either turn it on or off, depending on the type of lock and the key's shape. This can help regulate various bodily processes, but more research is needed to understand how mannosulfan works and what effects it has on the body.","oneSentence":"Mannosulfan is thought to work by interacting with a specific biological target, although the exact nature of this interaction is not yet understood.","technicalDetail":"Mannosulfan's mechanism of action is not well-characterized, but it is believed to involve binding to a specific protein or receptor, potentially altering its activity or expression."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4598","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MANNOSULFAN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MANNOSULFAN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:01:01.739257","biosimilars":[],"competitors":[{"drugName":"busulfan","drugSlug":"busulfan","fdaApproval":"1954-06-26","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"mannosulfan","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"busulfan","brandName":"busulfan","genericName":"busulfan","approvalYear":"1954","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06899321","phase":"NA","title":"The Effect of Cosmetic Products on Skin Brightening","status":"NOT_YET_RECRUITING","sponsor":"Unilever R&D","startDate":"2025-03","conditions":["Skin Brightening"],"enrollment":34,"completionDate":"2025-05"},{"nctId":"NCT03778450","phase":"","title":"Long-term Opioid Therapy, Misuse and Mortality in Patients With Chronic Non-cancer Pain in Germany","status":"COMPLETED","sponsor":"LinkCare GmbH","startDate":"2018-12-05","conditions":["Pain"],"enrollment":3232,"completionDate":"2019-08-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"135FQ40L36","INN_ID":"2968","UMLSCUI":"C0065696","ChEMBL_ID":"CHEMBL460282","KEGG_DRUG":"D07071","DRUGBANK_ID":"DB13334","PUBCHEM_CID":"20055482","MESH_SUPPLEMENTAL_RECORD_UI":"C100121"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"L01AB03","allCodes":["L01AB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"1979","pmid":"224835","title":"Influence of insulin on pharmacokinetics of mannosulfan in rats.","journal":"Archivum immunologiae et therapiae experimentalis"},{"date":"1978 May","pmid":"349802","title":"Prolongation of rat cardiac allograft survival by donor pretreatment. Screening of antineoplastic drugs.","journal":"Transplantation"},{"date":"1975","pmid":"181298","title":"Cytostatic treatment of polycythaemia rubra vera. Comparison of the effects of some cytostatics in 100 patients in a period of five years.","journal":"Haematologia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"MANNOSULFAN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannosulfan is a small molecule with a verified status in a clinical study (NCT06899321) for skin brightening and pain conditions. It was tested as part of cosmetic products M68, Z15, and R52 in a 6-week study.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}