{"id":"mannomustine","rwe":[{"pmid":"2512766","year":"1989","title":"A pharmacological approach to cellular mechanisms of PGI2-induced gastric cytoprotection on ethanol-induced gastric mucosal damage in rats.","finding":"","journal":"Acta physiologica Hungarica","studyType":"Clinical Study"},{"pmid":"2835242","year":"1987","title":"The effect of alkylating agents on the synaptic transmission in the frog's isolated sympathetic ganglion.","finding":"","journal":"European journal of drug metabolism and pharmacokinetics","studyType":"Clinical Study"},{"pmid":"6255694","year":"1980","title":"Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon peripheral and central processes of primary nociceptive neurons.","finding":"","journal":"Zeitschrift fur mikroskopisch-anatomische Forschung","studyType":"Clinical Study"},{"pmid":"349802","year":"1978","title":"Prolongation of rat cardiac allograft survival by donor pretreatment. Screening of antineoplastic drugs.","finding":"","journal":"Transplantation","studyType":"Clinical Study"},{"pmid":"791830","year":"1975","title":"Mannomustine (dihydrochloride).","finding":"","journal":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to man","studyType":"Clinical Study"}],"tags":[{"label":"mannomustine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Alkylating Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents, Alkylating","category":"pharmacology"},{"label":"Noxae","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mannomustin","offLabel":[],"synonyms":["mannomustine","mannitol mustard","mannomustin"],"timeline":[],"approvals":[],"brandName":"Mannomustin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mannomustine","explanation":"Imagine your cells are like a factory, and mannomustin is a tool that disrupts the factory's ability to make copies of itself. This can help slow down the growth of cancer cells, but it's a complex process and more research is needed to fully understand how it works.","oneSentence":"Mannomustin is thought to work by interfering with cellular processes, but the exact mechanism is not well understood.","technicalDetail":"Mannomustin is a mannomustine, a class of compounds that have been shown to have antitumor activity, but the exact molecular target and mechanism of action are unknown."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1633","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MANNOMUSTINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:30:09.692926","biosimilars":[],"competitors":[],"genericName":"mannomustine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"E60VWA40D2","CHEBI":"CHEBI:135296","INN_ID":"759","UMLSCUI":"C0024738","ChEMBL_ID":"CHEMBL460283","PUBCHEM_CID":"3033867","MESH_DESCRIPTOR_UI":"D008357"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":65,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"1989","pmid":"2512766","title":"A pharmacological approach to cellular mechanisms of PGI2-induced gastric cytoprotection on ethanol-induced gastric mucosal damage in rats.","journal":"Acta physiologica Hungarica"},{"date":"1987 Oct-Dec","pmid":"2835242","title":"The effect of alkylating agents on the synaptic transmission in the frog's isolated sympathetic ganglion.","journal":"European journal of drug metabolism and pharmacokinetics"},{"date":"1980","pmid":"6255694","title":"Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon peripheral and central processes of primary nociceptive neurons.","journal":"Zeitschrift fur mikroskopisch-anatomische Forschung"},{"date":"1978 May","pmid":"349802","title":"Prolongation of rat cardiac allograft survival by donor pretreatment. Screening of antineoplastic drugs.","journal":"Transplantation"},{"date":"1975","pmid":"791830","title":"Mannomustine (dihydrochloride).","journal":"IARC monographs on the evaluation of the carcinogenic risk of chemicals to man"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannomustin (MANNOMUSTINE) is a small molecule drug in the mannomustine class, but its target and mechanism of action are unknown. Its commercial status and approved indications are also unclear. As a result, key safety considerations and pharmacokinetic properties such as half-life and bioavailability are not well established. Further research is needed to fully understand this compound. Its ownership and patent status are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}