{"id":"mannitol-inhalant-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL689","moleculeType":"Small molecule","molecularWeight":"182.17"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When inhaled as a dry powder, mannitol particles absorb moisture from the airway epithelium and surrounding tissues, creating an osmotic gradient that increases airway surface liquid volume. This hydration of mucus and improved clearance helps mobilize secretions and may stimulate cough-mediated clearance, improving mucociliary function in patients with compromised airway clearance.","oneSentence":"Mannitol inhalant acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:55.295Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis (to improve airway clearance and lung function)"},{"name":"Bronchiectasis (to improve airway clearance)"}]},"trialDetails":[{"nctId":"NCT05740618","phase":"PHASE4","title":"Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2023-03-28","conditions":"Cystic Fibrosis","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Bronchitol; dry powder mannitol"],"phase":"marketed","status":"active","brandName":"Mannitol Inhalant Product","genericName":"Mannitol Inhalant Product","companyName":"University of North Carolina, Chapel Hill","companyId":"university-of-north-carolina-chapel-hill","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannitol inhalant acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance. Used for Cystic fibrosis (to improve airway clearance), Bronchiectasis (to improve airway clearance).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}