{"id":"mannitol-20-intravenous-fluid","safety":{"commonSideEffects":[{"rate":null,"effect":"Dehydration and hypovolemia"},{"rate":null,"effect":"Hypernatremia and electrolyte imbalance"},{"rate":null,"effect":"Rebound intracranial pressure elevation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Thrombophlebitis at injection site"}]},"_chembl":{"chemblId":"CHEMBL689","moleculeType":"Small molecule","molecularWeight":"182.17"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mannitol is a sugar alcohol that creates an osmotic gradient, pulling water from the extravascular and intracellular compartments into the blood vessels and then into the urine. This reduces brain edema and intracranial pressure by decreasing total body water content. It is filtered by the glomerulus but poorly reabsorbed by renal tubules, promoting diuresis and further fluid removal.","oneSentence":"Mannitol is an osmotic diuretic that draws fluid from tissues into the intravascular space and increases urine output to reduce intracranial and intraocular pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:51.874Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cerebral edema and elevated intracranial pressure"},{"name":"Acute glaucoma and elevated intraocular pressure"},{"name":"Oliguria and acute kidney injury prevention"}]},"trialDetails":[{"nctId":"NCT05884905","phase":"NA","title":"Safety of Short Hydration Method for Cisplatin Administration Compared With Conventional Hydration","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2023-03-07","conditions":"Renal Insufficiency, Cis-Platinum Nephropathy","enrollment":100},{"nctId":"NCT02760862","phase":"PHASE4","title":"Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2014-10","conditions":"Headache","enrollment":50},{"nctId":"NCT01954290","phase":"PHASE2","title":"Study of Stroke Related Edema Treatments","status":"WITHDRAWN","sponsor":"University of Florida","startDate":"2015-09","conditions":"Acute Cerebrovascular Accident, Cerebral Edema","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["mannitol 20% (Manufactured by Allmed Middle East, Egypt)."],"phase":"marketed","status":"active","brandName":"mannitol 20% intravenous fluid","genericName":"mannitol 20% intravenous fluid","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannitol is an osmotic diuretic that draws fluid from tissues into the intravascular space and increases urine output to reduce intracranial and intraocular pressure. Used for Cerebral edema and elevated intracranial pressure, Acute glaucoma and elevated intraocular pressure, Oliguria and acute kidney injury prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}