{"id":"mannitol-20-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Rebound intracranial pressure elevation"},{"rate":null,"effect":"Electrolyte imbalance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mannitol functions as an osmotic agent that creates an osmotic gradient, pulling water from the interstitial and intracellular compartments into the plasma. This reduces brain edema and intracranial pressure by decreasing total brain water content. It is filtered by the glomerulus but poorly reabsorbed in the renal tubules, promoting osmotic diuresis and increased urine output.","oneSentence":"Mannitol is an osmotic diuretic that draws fluid from tissues into the intravascular space and increases urine output to reduce intracranial pressure and cerebral edema.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:44.998Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of intracranial pressure and cerebral edema"},{"name":"Acute kidney injury prevention"},{"name":"Glaucoma management"}]},"trialDetails":[{"nctId":"NCT06408597","phase":"NA","title":"Mannitol Versus Nitroglycerin for Kidney Injury Prevention in Robotic-assisted Radical Prostatectomy or Cystectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Nazmy Edward Seif","startDate":"2024-05-12","conditions":"Prostate Cancer, Bladder Cancer, Surgery","enrollment":90},{"nctId":"NCT03778944","phase":"NA","title":"Enhancing Renal Graft Function During Donor Anesthesia","status":"RECRUITING","sponsor":"Nazmy Edward Seif","startDate":"2018-12-20","conditions":"Renal Failure Chronic, Transplant;Failure,Kidney, Anesthesia","enrollment":60},{"nctId":"NCT05428007","phase":"PHASE2","title":"Interleukin-6 Receptor Inhibitor Sarilumab in Combination With Ipilimumab, Nivolumab and Relatlimab in Patients With Unresectable Stage III or Stage IV Melanoma","status":"RECRUITING","sponsor":"NYU Langone Health","startDate":"2023-02-02","conditions":"Melanoma, Unresectable Melanoma","enrollment":105},{"nctId":"NCT06488534","phase":"NA","title":"Intracolonic FODMAP Infusion in Healthy Volunteers","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2023-06-26","conditions":"Irritable Bowel Syndrome","enrollment":15},{"nctId":"NCT06542198","phase":"NA","title":"Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2024-09-10","conditions":"Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency, Primary Polydipsia","enrollment":42},{"nctId":"NCT04428372","phase":"PHASE2, PHASE3","title":"MAnnitol for Blood Pressure Stability in HemoDialysis (MAP-HD)","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2021-04-06","conditions":"Hemodialysis Complication, Hemodynamic Instability","enrollment":31},{"nctId":"NCT03970447","phase":"PHASE2, PHASE3","title":"A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma","status":"RECRUITING","sponsor":"Global Coalition for Adaptive Research","startDate":"2019-07-30","conditions":"Glioblastoma","enrollment":1280},{"nctId":"NCT02433509","phase":"PHASE1","title":"Phase I Clinical Safety Study About Human Umbilical Cord Blood Monocyte in the Acute Ischemic Stroke","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2015-05","conditions":"Acute Ischemic Stroke","enrollment":6},{"nctId":"NCT02800486","phase":"PHASE2","title":"Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA","status":"RECRUITING","sponsor":"Northwell Health","startDate":"2016-05","conditions":"Glioblastoma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma","enrollment":37},{"nctId":"NCT02861898","phase":"PHASE1, PHASE2","title":"Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma","status":"RECRUITING","sponsor":"Northwell Health","startDate":"2016-06","conditions":"Glioblastoma, Brain Cancer, Brain Neoplasm","enrollment":33},{"nctId":"NCT04217421","phase":"PHASE3","title":"Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass","status":"RECRUITING","sponsor":"dr. 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