{"id":"mannite-hexanitrate","rwe":[{"pmid":"27933669","year":"2017","title":"Characterization of nitrated sugar alcohols by atmospheric-pressure chemical-ionization mass spectrometry.","finding":"","journal":"Rapid communications in mass spectrometry : RCM","studyType":"Clinical Study"},{"pmid":"21214268","year":"2011","title":"Theoretical prediction of properties of aliphatic polynitrates.","finding":"","journal":"The journal of physical chemistry. A","studyType":"Clinical Study"},{"pmid":"19016851","year":"2008","title":"Reduction of aliphatic nitroesters and N-nitramines by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships.","finding":"","journal":"The FEBS journal","studyType":"Clinical Study"},{"pmid":"2900744","year":"1988","title":"Biotransformation of organic nitrate esters in vitro by human liver, kidney, intestine, and blood serum.","finding":"","journal":"Drug metabolism and disposition: the biological fate of chemicals","studyType":"Clinical Study"},{"pmid":"6432996","year":"1984","title":"Pharmacokinetics of nitroglycerin after parenteral and oral dosing in the rat.","finding":"","journal":"Journal of pharmaceutical sciences","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"manexin","offLabel":[],"synonyms":["d-mannitol hexanitrate","hexanitrol","hypertenain","maltrate","manexin","manicole","mannitate","mannite hexanitrate","mannitol nitrate","nitranitol","nitromannitol"],"timeline":[],"approvals":[],"brandName":"Manexin","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine Manexin as a key that fits into a specific lock in the body. When it binds to that lock, it can turn on or off certain processes that help to treat a particular disease or condition. This is a simplified way of understanding how small molecules like Manexin work to produce their effects.","oneSentence":"Manexin works by binding to specific biological molecules to produce a therapeutic effect.","technicalDetail":"Manexin's mechanism of action is likely to involve the interaction with specific receptors or enzymes, potentially altering signaling pathways or modulating the activity of key biological molecules."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3330","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mannite hexanitrate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:30:04.667283","biosimilars":[],"competitors":[],"genericName":"mannite hexanitrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"99AU28W1G9","CHEBI":"CHEBI:135734","INN_ID":"143","ChEMBL_ID":"CHEMBL2104740","PUBCHEM_CID":"61818"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2017 Feb 28","pmid":"27933669","title":"Characterization of nitrated sugar alcohols by atmospheric-pressure chemical-ionization mass spectrometry.","journal":"Rapid communications in mass spectrometry : RCM"},{"date":"2011 Feb 10","pmid":"21214268","title":"Theoretical prediction of properties of aliphatic polynitrates.","journal":"The journal of physical chemistry. A"},{"date":"2008 Dec","pmid":"19016851","title":"Reduction of aliphatic nitroesters and N-nitramines by Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: quantitative structure-activity relationships.","journal":"The FEBS journal"},{"date":"1988 May-Jun","pmid":"2900744","title":"Biotransformation of organic nitrate esters in vitro by human liver, kidney, intestine, and blood serum.","journal":"Drug metabolism and disposition: the biological fate of chemicals"},{"date":"1984 Jul","pmid":"6432996","title":"Pharmacokinetics of nitroglycerin after parenteral and oral dosing in the rat.","journal":"Journal of pharmaceutical sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Manexin is a small molecule with the synonyms D-MANNITOL HEXANITRATE, HEXANITRATE DE MANNITOL, and others. Its modality is classified as a small molecule.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}