{"id":"mandelic-acid","rwe":[],"tags":[{"label":"mandelic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B05CA06","category":"atc"},{"label":"Active","category":"status"},{"label":"Urinary tract infectious disease","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amygdalic acid","offLabel":[],"synonyms":["mandelic acid","2-Phenylglycolic acid","amygdalic acid","paramandelic acid","phenylglycolic acid","phenylhydroxyacetic acid"],"timeline":[],"approvals":[],"brandName":"Amygdalic Acid","ecosystem":[{"indication":"Urinary tract infectious disease","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"acetohydroxamic acid","slug":"acetohydroxamic-acid","company":"Mission Pharma"},{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"mandelic acid","explanation":"Imagine your body's immune system as a defense army. Amygdalic Acid is like a special soldier that helps the army fight off the enemy (bacteria) by stopping them from multiplying and taking over. This helps to clear up infections and prevent further damage.","oneSentence":"Amygdalic Acid works by inhibiting bacterial growth and replication in the urinary tract.","technicalDetail":"Amygdalic Acid exerts its antibacterial effects by interfering with the bacterial cell wall synthesis, ultimately leading to bacterial cell death."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Mandelic_acid","title":"Mandelic acid","extract":"Mandelic acid is an aromatic alpha hydroxy acid (AHA) with the molecular formula C6H5CH(OH)CO2H. It is a white crystalline solid that is soluble in water and polar organic solvents. Its principal use in organic synthesis is as a useful precursor to various drugs.","wiki_history":"==History==\nMandelic acid was discovered in 1831 by the German pharmacist Ferdinand Ludwig Winckler (1801–1868) while heating amygdalin, an extract of bitter almonds, with diluted hydrochloric acid. The name is derived from the German \"Mandel\" for \"almond\"."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1629","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=mandelic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mandelic acid","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Mandelic_acid","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:05:29.277830","biosimilars":[],"competitors":[{"drugName":"cetylpyridinium","drugSlug":"cetylpyridinium","fdaApproval":"","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"nitrofurazone","drugSlug":"nitrofurazone","fdaApproval":"1945-10-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"sulfamethizole","drugSlug":"sulfamethizole","fdaApproval":"1953-10-28","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"neomycin","drugSlug":"neomycin","fdaApproval":"1957-03-26","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"mandelic acid","indications":{"approved":[{"name":"Urinary tract infectious disease","source":"DrugCentral","snomedId":68566005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cetylpyridinium","brandName":"cetylpyridinium","genericName":"cetylpyridinium","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"},{"drugId":"nitrofurazone","brandName":"nitrofurazone","genericName":"nitrofurazone","approvalYear":"1945","relationship":"same-class"},{"drugId":"sulfamethizole","brandName":"sulfamethizole","genericName":"sulfamethizole","approvalYear":"1953","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07401342","phase":"PHASE4","title":"An Assessment of the Efficacy and Safety of Employing a Duosomal Chemical Peel for Aesthetic Enhancement in the Periocular and Facial Regions","status":"COMPLETED","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2023-11-01","conditions":["Chemical Peeling"],"enrollment":12,"completionDate":"2024-01-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003994","UNII":"NH496X0UJX","RXNORM":"29256","UMLSCUI":"C0065636","ChEMBL_ID":"CHEMBL1609","DRUGBANK_ID":"DB13218","PUBCHEM_CID":"1292","SNOMEDCT_US":"350156008","MESH_SUPPLEMENTAL_RECORD_UI":"C037938"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1516,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"B05CA06","allCodes":["B05CA06","J01XX06"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Amygdalic Acid, also known as mandelic acid, is a small molecule drug in the mandelic acid class. It is used to treat urinary tract infectious diseases. The commercial status of Amygdalic Acid is not specified, but it is approved for use in certain indications. Key safety considerations are not provided. Further research is needed to determine its pharmacokinetic properties.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}