{"id":"malathion-gel-0-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Scalp irritation"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Burning sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Malathion works by irreversibly inhibiting the enzyme acetylcholinesterase in insects and parasites, leading to excessive acetylcholine accumulation at nerve synapses and neuromuscular junctions. This results in overstimulation, paralysis, and death of the target organisms. The gel formulation allows topical application for localized treatment of parasitic infestations.","oneSentence":"Malathion is an organophosphate insecticide that inhibits acetylcholinesterase, causing accumulation of acetylcholine and paralysis of parasites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:06.182Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head lice infestation (pediculosis capitis)"},{"name":"Scabies (Sarcoptes scabiei infestation)"}]},"trialDetails":[{"nctId":"NCT00927472","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2009-08","conditions":"Pediculosis","enrollment":254},{"nctId":"NCT00963508","phase":"PHASE3","title":"Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2009-08","conditions":"Pediculosis","enrollment":403},{"nctId":"NCT00927407","phase":"PHASE1","title":"Pharmacokinetics of Malathion Gel 0.5% and Malathion 0.5% Lotion (Ovide) in Patients With Head Lice","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2009-07","conditions":"Pediculosis","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MALG"],"phase":"phase_3","status":"active","brandName":"Malathion gel 0.5%","genericName":"Malathion gel 0.5%","companyName":"Sun Pharmaceutical Industries, Inc.","companyId":"sun-pharmaceutical-industries-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Malathion is an organophosphate insecticide that inhibits acetylcholinesterase, causing accumulation of acetylcholine and paralysis of parasites. Used for Head lice infestation (pediculosis capitis), Scabies (Sarcoptes scabiei infestation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}