{"id":"maintenance-of-alpha-blocker-and-5-ari","safety":{"commonSideEffects":[{"rate":null,"effect":"Erectile dysfunction"},{"rate":null,"effect":"Decreased libido"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Retrograde ejaculation"},{"rate":null,"effect":"Orthostatic hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha-blockers relax smooth muscle in the prostate and bladder neck to improve urinary flow and reduce lower urinary tract symptoms. 5-alpha reductase inhibitors (5-ARI) block conversion of testosterone to dihydrotestosterone, reducing prostate size over time. Together, they address both acute symptom relief and long-term disease progression in benign prostatic hyperplasia.","oneSentence":"This combination therapy maintains symptom relief in benign prostatic hyperplasia by combining alpha-blocker-mediated smooth muscle relaxation with 5-alpha reductase inhibitor-mediated reduction of prostate volume.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:05.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Benign prostatic hyperplasia with lower urinary tract symptoms"}]},"trialDetails":[{"nctId":"NCT05023824","phase":"PHASE3","title":"Efficacy of α-blocker or 5-ARI Withdrawal to Continued Combination Therapy on the Maintenance of LUTS in Men With BPH","status":"UNKNOWN","sponsor":"Gangnam Severance Hospital","startDate":"2020-12-08","conditions":"Prostatic Hyperplasia, Prostate Hyperplasia, Prostatic Hypertrophy","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Maintenance of alpha-blocker and 5-ARI","genericName":"Maintenance of alpha-blocker and 5-ARI","companyName":"Gangnam Severance Hospital","companyId":"gangnam-severance-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination therapy maintains symptom relief in benign prostatic hyperplasia by combining alpha-blocker-mediated smooth muscle relaxation with 5-alpha reductase inhibitor-mediated reduction of prostate volume. Used for Benign prostatic hyperplasia with lower urinary tract symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}