{"id":"magnesium-sulphate-intramuscular","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Depressed reflexes"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypermagnesemia (at high doses)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium sulphate works through multiple mechanisms: it antagonizes NMDA receptors to reduce neuronal excitability, acts as a natural calcium antagonist to decrease acetylcholine release at the neuromuscular junction, and produces vasodilation. These properties make it effective for seizure prophylaxis and management of severe hypertension in obstetric emergencies.","oneSentence":"Magnesium sulphate acts as a central nervous system depressant and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and reducing neuromuscular transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:54.782Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure prophylaxis and treatment in preeclampsia and eclampsia"},{"name":"Severe hypertension in pregnancy"},{"name":"Arrhythmia management (torsades de pointes)"},{"name":"Asthma exacerbation (acute severe)"}]},"trialDetails":[{"nctId":"NCT02938520","phase":"PHASE3","title":"Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants","status":"ACTIVE_NOT_RECRUITING","sponsor":"ViiV Healthcare","startDate":"2016-10-27","conditions":"HIV Infections","enrollment":631},{"nctId":"NCT07390851","phase":"NA","title":"Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG.","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-11-26","conditions":"Myofascial Pain Dysfunction Syndrome","enrollment":28},{"nctId":"NCT06997575","phase":"PHASE4","title":"Comparing Intravenous and Intramuscular Magnesium Sulphate for Preventing Seizure Recurrence in Women With Eclampsia","status":"COMPLETED","sponsor":"Nishtar Medical University","startDate":"2025-05-13","conditions":"Eclampsia, Seizures, Pregnancy","enrollment":200},{"nctId":"NCT05828966","phase":"NA","title":"HUMAN CHORIONIC GONADOTROPIN (HcG) VS MAGNESIUM SULPHATE (MgSo4) AS A TOCOLYTIC AGENT- A RANDOMIZED CONTROLLED TRIAL","status":"COMPLETED","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2023-02-15","conditions":"Preterm Labor","enrollment":70},{"nctId":"NCT04027036","phase":"PHASE2","title":"Comparison of Immunogenicity of Inactivated Poliovirus Vaccine (IPV) Administered Intramuscularly or Intradermally","status":"COMPLETED","sponsor":"Instituto Nacional de Saúde, Mozambique","startDate":"2020-08-06","conditions":"Polio","enrollment":382},{"nctId":"NCT05653401","phase":"PHASE2","title":"Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine.","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2022-11-20","conditions":"Renal Colic","enrollment":800},{"nctId":"NCT04539249","phase":"NA","title":"Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section","status":"COMPLETED","sponsor":"Olakunle Ifeoluwa Makinde","startDate":"2020-11-04","conditions":"Acute Post-operative Pain Following Caesarean Section","enrollment":324},{"nctId":"NCT02728037","phase":"PHASE3","title":"Magnesium-Based Trigger Point Injections for Relief of Chronic Myofascial Pelvic Pain","status":"TERMINATED","sponsor":"Queen's University","startDate":"2016-04","conditions":"Pelvic Pain","enrollment":38},{"nctId":"NCT03199924","phase":"PHASE2","title":"Treatment of Renal Colic in the Emergency Departement (ED).","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2016-07-01","conditions":"Renal Colic","enrollment":600},{"nctId":"NCT04501289","phase":"NA","title":"Low Dose Magnesium Sulphate Versus Standard Pritchard Regimen In Management Of Severe Preeclampsia/Eclampsia","status":"COMPLETED","sponsor":"Adebayo Joshua Adeniyi","startDate":"2017-05-08","conditions":"Preeclampsia/Eclampsia","enrollment":114},{"nctId":"NCT01911494","phase":"NA","title":"Community Level Interventions for Pre-eclampsia","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2013-09","conditions":"Pre-eclampsia, Hypertension, Pregnancy Induced","enrollment":87500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":101,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MgSO4 intramuscular"],"phase":"marketed","status":"active","brandName":"Magnesium sulphate intramuscular","genericName":"Magnesium sulphate intramuscular","companyName":"Nishtar Medical University","companyId":"nishtar-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium sulphate acts as a central nervous system depressant and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and reducing neuromuscular transmission. Used for Seizure prophylaxis and treatment in preeclampsia and eclampsia, Severe hypertension in pregnancy, Arrhythmia management (torsades de pointes).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}