{"id":"magnesium-sulfate-in-plastic-container","rwe":[{"pmid":"41881424","year":"2026","title":"Factors associated with appropriate administration of magnesium sulfate for neuroprotection prior to early preterm birth.","finding":"","journal":"American journal of obstetrics & gynecology MFM","studyType":"Clinical Study"},{"pmid":"41875944","year":"2026","title":"Penetration resistance of fiber-reinforced basic magnesium sulfate concrete: Experimental and numerical investigations.","finding":"","journal":"Journal of advanced research","studyType":"Clinical Study"},{"pmid":"41868288","year":"2026","title":"The Effect of Cocktail Formula Solution for Erector Spinae Plane Block on Postoperative Pain After Laparoscopic Major Upper Abdominal Surgery: A Single-Center Randomized Controlled Study.","finding":"","journal":"Journal of pain research","studyType":"Clinical Study"},{"pmid":"41862797","year":"2026","title":"Systemic administration of magnesium sulfate enhances lidocaine-induced sciatic nerve block and exerts analgesic effects in postsurgical pain in rats.","finding":"","journal":"BMC anesthesiology","studyType":"Clinical Study"},{"pmid":"41859579","year":"2026","title":"Beyond HELLP: An Unusual Cause of Severe Thrombocytopenia in Pregnancy.","finding":"","journal":"Cureus","studyType":"Clinical Study"}],"_fda":{"id":"6800cc90-07b3-4811-90f4-0bcfb9bee8f1","set_id":"03ebeabb-8386-4af4-3086-bdf3c3fc4a5a","openfda":{"unii":["SK47B8698T"],"route":["INTRAVENOUS"],"rxcui":["829757"],"spl_id":["6800cc90-07b3-4811-90f4-0bcfb9bee8f1"],"brand_name":["Magnesium Sulfate in Dextrose"],"spl_set_id":["03ebeabb-8386-4af4-3086-bdf3c3fc4a5a"],"package_ndc":["0409-6727-11","0409-6727-23","0409-6727-55","0409-6727-50"],"product_ndc":["0409-6727"],"generic_name":["MAGNESIUM SULFATE IN DEXTROSE"],"product_type":["HUMAN PRESCRIPTION DRUG"],"substance_name":["MAGNESIUM SULFATE HEPTAHYDRATE"],"manufacturer_name":["Hospira, Inc."],"application_number":["NDA020488"],"is_original_packager":[true]},"version":"31","pregnancy":["8.1 Pregnancy Risk Summary Magnesium Sulfate in 5% Dextrose Injection is indicated in pregnant women for the prevention of eclampsia in women with preeclampsia and the treatment of seizures and prevention of recurrent seizures in women with eclampsia. Fetal, neonatal, and maternal risks are discussed throughout the labeling. Clinical Considerations Labor or Delivery: Magnesium Sulfate in 5% Dextrose Injection is not approved for the treatment of pre-term labor. Administration of Magnesium Sulfate in 5% Dextrose Injection to pregnant women longer than 5 to 7 days may lead to hypocalcemia and bone abnormalities in the developing fetus, including skeletal demineralization and osteopenia [see Warnings and Precautions (5.1) ] ."],"overdosage":["10 OVERDOSAGE Manifestations of magnesium toxicity include a drop in blood pressure, difficulty breathing, and disappearance of the patellar reflex. As serum magnesium rises above 4 mEq per liter, the deep tendon reflexes decrease. As the serum magnesium level approaches 10 mEq per liter, the tendon reflexes disappear and respiratory paralysis may occur [see Warnings and Precautions (5.2) ] . Other signs and symptoms of magnesium overdosage include flushing, sweating, hypotension, weakness, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis, cardiac arrest, and prolongation of PR and QRS intervals. Patients with renal impairment and underlying neuromuscular diseases such as myasthenia gravis may experience magnesium intoxication at lower magnesium concentrations (Magnesium Sulfate in 5% Dextrose Injection is contraindicated in patients with myasthenia gravis). If patient is experiencing magnesium toxicity, immediately discontinue Magnesium Sulfate in 5% Dextrose Injection. Artificial respiration may be required. Administer an injectable calcium salt to counteract the potential hazards of magnesium toxicity [see Warnings and Precautions (5.2) ] . Hypermagnesemia in the newborn (after administration of Magnesium Sulfate in 5% Dextrose Injection to the mother) may require resuscitation and assisted ventilation via endotracheal intubation or intermittent positive pressure ventilation as well as intravenous calcium."],"description":["11 DESCRIPTION Magnesium Sulfate in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate and dextrose in water for injection for intravenous use. Each 100 mL contains 1 gram of magnesium sulfate heptahydrate and dextrose, hydrous 5 grams in water for injection [see How Supplied/Storage and Handling (16) ] . Magnesium Sulfate in 5% Dextrose Injection, USP may contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). Magnesium Sulfate, USP heptahydrate is chemically known as sulfuric acid magnesium salt (1:1), heptahydrate and chemically designated MgSO 4 ∙ 7H 2 O, with a molecular weight of 246.47. It occurs as colorless crystals or white powder freely soluble in water. Dextrose, USP is chemically designated D-glucose, monohydrate, a hexose sugar freely soluble in water. The molecular formula is C 6 H 12 O 6 ∙ H 2 O and the molecular weight is 198.17. It has the following structural formula: Water for Injection, USP is chemically designated H 2 O. Water can permeate from inside the flexible plastic container into the overwrap [see Dosage and Administration (2.1) ] but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C (77°F) during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. Chemical Structure"],"how_supplied":["16 HOW SUPPLIED/STORAGE AND HANDLING Magnesium Sulfate in 5% Dextrose Injection, USP is a clear solution supplied in single-dose flexible plastic containers (see Table 2 ). Table 2: How Supplied Information NDC Number (Unit of Sale) Concentration Total Magnesium Sulfate As the heptahydrate; Total Magnesium Ion Magnesium Sulfate Concentration Magnesium Ion Concentration Osmolarity Osmolarity was calculated. NDC 0409-6727-23 Case of 24 single-dose flexible plastic containers 1 g/100 mL (10 mg/mL) 1 g 8.1 mEq 0.01 g/mL (1%) 8.1 mEq/100 mL 333 mOsmol/liter NDC 0409-6727-50 Case of 50 single-dose flexible plastic containers 1 g/100 mL (10 mg/mL) 1 g 8.1 mEq 0.01 g/mL (1%) 8.1 mEq/100 mL 333 mOsmol/liter Storage Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature.] Protect from freezing."],"pediatric_use":["8.4 Pediatric Use The safety and effectiveness of Magnesium Sulfate in 5% Dextrose Injection have been established for the prevention of eclampsia in adolescents with preeclampsia and the treatment of seizures and prevention of recurrent seizures in adolescents with eclampsia. Dosing recommendation in pregnant adolescent patients are the same as for pregnant adult patients [see Dosage and Administration (2.2) ] ."],"effective_time":"20260211","pharmacodynamics":["12.2 Pharmacodynamics With intravenous administration of magnesium sulfate the onset of anticonvulsant action is immediate and lasts about 30 minutes. The estimated magnesium concentration (above baseline) required to elicit half-maximum effect (EC 50 ) on systolic and diastolic blood pressure in pregnant women with preeclampsia that received intravenous magnesium sulfate therapy was reported to be 1.5 and 1.8 mEq per liter (1.9 and 2.2 mg per dL), respectively, in a published study. Effective anticonvulsant serum concentrations range from 2.5 to 7.5 mEq per liter. Drug Interaction Studies The following information is based upon published case reports and clinical studies that could not be confirmed by an adequately controlled study, but still warrant consideration given the potential risks involved [see Drug Interactions (7) ] . Neuromuscular Blocking Agents: Potentiation and prolongation of neuromuscular blockade requiring modification of the neuromuscular blocking agent dosage and/or increased reversal agent requirements were reported in preeclamptic women who received magnesium sulfate treatment who underwent subsequent surgery (for example, caesarian section) with anesthesia that included either a depolarizing (d-tubocurarine, succinylcholine) or nondepolarizing neuromuscular blocking agent (vecuronium, rocuronium). Narcotics and/or Propofol: Potentiation and prolongation of analgesic and/or sedative effects as well as a reduced requirement for an intravenous narcotic (fentanyl, sufentanil, tramadol), intrathecal narcotic (fentanyl), and/or intravenous propofol was reported in magnesium sulfate treated patients who required surgery or intensive care that also included narcotic and/or propofol therapy. Dihydropyridine Calcium Channel Blockers: An exaggerated hypotensive response (blood pressure 80–93/49–60 mm Hg) was reported in preeclamptic women who received oral nifedipine in addition to magnesium sulfate treatment. Blood pressure returned to previous levels within approximately 30 minutes with supportive care."],"pharmacokinetics":["12.3 Pharmacokinetics Distribution Approximately 1 to 2% of total body magnesium is located in the extracellular fluid space. Magnesium is 30% bound to albumin. Elimination The average half-life and systemic clearance of magnesium sulfate in preeclamptic women is approximately 4 to 5 hours and 4 to 5 liters per hour, respectively. Excretion: Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration. Specific Populations Patients with Renal Impairment: Plasma magnesium concentrations of 7 to 12.3 mEq per liter (8.6 to 15.1 mg per dL) were reported in preeclamptic women with a urine output less than 100 mL per 4 hours that received 20 grams of magnesium sulfate intravenously over 2 to 8 hours in a published study [see Dosage and Administration (2.3) and Use in Specific Populations (8.6) ] ."],"adverse_reactions":["6 ADVERSE REACTIONS The following adverse reactions have been identified in clinical studies or postmarketing reports. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Cardiovascular: hypotension, circulatory collapse, cardiac depression including bradycardia Central Nervous System: central nervous system depression leading to respiratory paralysis, visual disturbances, flushing, sweating, hypothermia Metabolic: hypocalcemia with signs of tetany, hypermagnesemia Neurologic: lethargy, sedation, somnolence, myasthenic crisis Neuromuscular: depressed deep tendon reflexes, flaccid paralysis Pulmonary: decreased respiratory rate, pulmonary edema The most common adverse reactions are flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system (CNS) depression proceeding to respiratory paralysis and hypocalcemia. Bradycardia, pulmonary edema, decreased respiratory rate, lethargy, sedation, somnolence, visual disturbances, and hypermagnesemia are also reported ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc., at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch ."],"contraindications":["4 CONTRAINDICATIONS Magnesium Sulfate in 5% Dextrose Injection is contraindicated in patients: • with heart block or myocardial damage • in diabetic coma • with myasthenia gravis [see Warnings and Precautions (5.6) ] • Heart block or myocardial damage ( 4 ) • Diabetic coma ( 4 ) • Myasthenia gravis ( 4 , 5.6 )"],"drug_interactions":["7 DRUG INTERACTIONS Table 1 presents the potential clinical impact of medications that may be commonly administered concomitantly with Magnesium Sulfate in 5% Dextrose Injection in the clinical setting. Table 1: Potential Clinically Significant Drug Interactions with Magnesium Sulfate in 5% Dextrose Injection For drug incompatibility information [see Dosage and Administration (2.4) ] . Neuromuscular Blocking Agents Clinical Impact: • Potentiation and prolongation of neuromuscular blockade is possible with the concomitant use of magnesium sulfate and neuromuscular blocking agents [see Clinical Pharmacology (12.2) ] . • The underlying mechanism of this interaction may involve suppression of peripheral neuromuscular function by decreasing acetylcholine release, reduction of endplate sensitivity, and decreased muscle fiber excitability with magnesium sulfate therapy. Intervention: • Monitor respiration and the depth of neuromuscular blockade frequently (e.g., train-of-four monitoring) when a neuromuscular blocking agent is used concomitantly with Magnesium Sulfate in 5% Dextrose Injection. • Adjust the dosage of the neuromuscular blocking agent accordingly to maintain the desired level of musculoskeletal activity. The amount of reversal agent(s) required to achieve adequate reversal of the neuromuscular blocking agent(s) may also be increased. Examples: • Depolarizing neuromuscular blockers: succinylcholine • Non-depolarizing neuromuscular blockers: atracurium, cisatracurium, pancuronium, rocuronium, vecuronium Narcotics and/or Propofol Clinical Impact: • Potentiation and prolongation of analgesia and CNS depression is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection with narcotics and/or propofol. The potential for magnesium sulfate to affect other CNS depressants is unknown [see Clinical Pharmacology (12.2) ] . • The underlying mechanism of this interaction may involve antagonism of N-methyl-D-aspartate (NMDA) by magnesium sulfate therapy. Intervention: • Monitor the depth of CNS depression frequently using a reliable instrument. • Adjust the narcotic and/or propofol dosage accordingly to maintain the desired level of analgesia and sedation. Examples: • Narcotics and propofol Dihydropyridine Calcium Channel Blockers Clinical Impact: • An exaggerated hypotensive response is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection with dihydropyridine calcium channel blockers. The potential for magnesium sulfate to affect other calcium channel blockers (e.g., diltiazem and verapamil) is unknown [see Clinical Pharmacology (12.2) ] . Intervention: • Monitor vital signs (heart rate, blood pressure, respiration) frequently. • Supportive care and/or discontinuation of the calcium channel blocker may be required. Examples: • Amlodipine, clevidipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, and nisoldipine Drugs that May Induce Magnesium Loss Clinical Impact: • Reduced magnesium concentrations may impact efficacy Intervention: • Monitor magnesium concentrations frequently and adjust the Magnesium Sulfate in 5% Dextrose Injection dosage to maintain concentrations in the target range [see Dosage and Administration (2) ] . Examples: • Alcohol, aminoglycosides, amphotericin B, cisplatin, cyclosporine, digitalis, loop diuretics, thiazide diuretics • Neuromuscular blocking agents : Potentiation and prolongation of neuromuscular blockade is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection ( 7 ) • Narcotics and/or propofol : Potentiation and prolongation of analgesia and CNS depression is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection ( 7 ) • Dihydropyridine calcium channel blockers : An exaggerated hypotensive response is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection ( 7 ) • Drugs that may induce magnesium loss with concomitant use of Magnesium Sulfate in 5% Dextrose Injection : Alcohol, aminoglycosides, amphotericin B, cisplatin, cyclosporine, digitalis, loop diuretics, and thiazide diuretics ( 7 )"],"how_supplied_table":["
Table 2: How Supplied Information
NDC Number (Unit of Sale)ConcentrationTotal Magnesium SulfateAs the heptahydrate;Total Magnesium IonMagnesium Sulfate ConcentrationMagnesium Ion ConcentrationOsmolarityOsmolarity was calculated.
NDC 0409-6727-23 Case of 24 single-dose flexible plastic containers1 g/100 mL (10 mg/mL)1 g8.1 mEq0.01 g/mL (1%)8.1 mEq/100 mL333 mOsmol/liter
NDC 0409-6727-50 Case of 50 single-dose flexible plastic containers1 g/100 mL (10 mg/mL)1 g8.1 mEq0.01 g/mL (1%)8.1 mEq/100 mL333 mOsmol/liter
"],"labor_and_delivery":["Labor or Delivery: Magnesium Sulfate in 5% Dextrose Injection is not approved for the treatment of pre-term labor. Administration of Magnesium Sulfate in 5% Dextrose Injection to pregnant women longer than 5 to 7 days may lead to hypocalcemia and bone abnormalities in the developing fetus, including skeletal demineralization and osteopenia [see Warnings and Precautions (5.1) ] ."],"mechanism_of_action":["12.1 Mechanism of Action Magnesium prevents seizures in patients with preeclampsia and controls seizures in patients with eclampsia by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium has a depressant effect on the central nervous system [see Drug Interactions (7) ] . Magnesium acts peripherally to produce vasodilation."],"storage_and_handling":["Storage Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature.] Protect from freezing."],"clinical_pharmacology":["12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Magnesium prevents seizures in patients with preeclampsia and controls seizures in patients with eclampsia by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium has a depressant effect on the central nervous system [see Drug Interactions (7) ] . Magnesium acts peripherally to produce vasodilation. 12.2 Pharmacodynamics With intravenous administration of magnesium sulfate the onset of anticonvulsant action is immediate and lasts about 30 minutes. The estimated magnesium concentration (above baseline) required to elicit half-maximum effect (EC 50 ) on systolic and diastolic blood pressure in pregnant women with preeclampsia that received intravenous magnesium sulfate therapy was reported to be 1.5 and 1.8 mEq per liter (1.9 and 2.2 mg per dL), respectively, in a published study. Effective anticonvulsant serum concentrations range from 2.5 to 7.5 mEq per liter. Drug Interaction Studies The following information is based upon published case reports and clinical studies that could not be confirmed by an adequately controlled study, but still warrant consideration given the potential risks involved [see Drug Interactions (7) ] . Neuromuscular Blocking Agents: Potentiation and prolongation of neuromuscular blockade requiring modification of the neuromuscular blocking agent dosage and/or increased reversal agent requirements were reported in preeclamptic women who received magnesium sulfate treatment who underwent subsequent surgery (for example, caesarian section) with anesthesia that included either a depolarizing (d-tubocurarine, succinylcholine) or nondepolarizing neuromuscular blocking agent (vecuronium, rocuronium). Narcotics and/or Propofol: Potentiation and prolongation of analgesic and/or sedative effects as well as a reduced requirement for an intravenous narcotic (fentanyl, sufentanil, tramadol), intrathecal narcotic (fentanyl), and/or intravenous propofol was reported in magnesium sulfate treated patients who required surgery or intensive care that also included narcotic and/or propofol therapy. Dihydropyridine Calcium Channel Blockers: An exaggerated hypotensive response (blood pressure 80–93/49–60 mm Hg) was reported in preeclamptic women who received oral nifedipine in addition to magnesium sulfate treatment. Blood pressure returned to previous levels within approximately 30 minutes with supportive care. 12.3 Pharmacokinetics Distribution Approximately 1 to 2% of total body magnesium is located in the extracellular fluid space. Magnesium is 30% bound to albumin. Elimination The average half-life and systemic clearance of magnesium sulfate in preeclamptic women is approximately 4 to 5 hours and 4 to 5 liters per hour, respectively. Excretion: Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration. Specific Populations Patients with Renal Impairment: Plasma magnesium concentrations of 7 to 12.3 mEq per liter (8.6 to 15.1 mg per dL) were reported in preeclamptic women with a urine output less than 100 mL per 4 hours that received 20 grams of magnesium sulfate intravenously over 2 to 8 hours in a published study [see Dosage and Administration (2.3) and Use in Specific Populations (8.6) ] ."],"indications_and_usage":["1 INDICATIONS AND USAGE Magnesium Sulfate in 5% Dextrose Injection is indicated for: • Prevention of eclampsia in patients with preeclampsia • Treatment of seizures and prevention of recurrent seizures in patients with eclampsia Magnesium Sulfate in 5% Dextrose Injection is indicated for ( 1 ): • Prevention of eclampsia in patients with preeclampsia ( 1 ) • Treatment of seizures and prevention of recurrent seizures in patients with eclampsia ( 1 )"],"warnings_and_cautions":["5 WARNINGS AND PRECAUTIONS • Fetal-neonatal toxicity with prolonged use : Administration beyond 5 to 7 days is not recommended and can lead to hypocalcemia and bone abnormalities ( 2.2 , 5.1 ) • Risk of magnesium toxicity : Monitor magnesium concentrations and clinical signs of magnesium toxicity including respiratory depression, an injectable calcium salt should be immediately available to counteract hazards, for significant toxicity stop Magnesium Sulfate in 5% Dextrose Injection ( 5.2 ) • Risk of elevated blood glucose: Solutions containing dextrose should be used with caution in patients with known prediabetes or diabetes mellitus ( 5.3 ) • Co-administration with unapproved tocolytics : Do not use concomitantly with beta adrenergic agents such as terbutaline and calcium channel blockers such as nifedipine ( 5.4 ) • Aluminum toxicity : Aluminum may reach toxic concentrations with prolonged parenteral administration in patients with renal impairment ( 5.5 ) • Exacerbation of Myasthenia Gravis : Use is contraindicated because use in patients with underlying myasthenia gravis can precipitate a myasthenic crisis ( 5.6 ) 5.1 Fetal-Neonatal Toxicity with Prolonged Use Continuous administration of magnesium sulfate beyond 5 to 7 days in pregnant women can lead to hypocalcemia and bone abnormalities in the developing fetus, including skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported. Neonates of women receiving Magnesium Sulfate in 5% Dextrose Injection (especially with prolonged maternal use) are at risk for magnesium toxicity including hyporeflexia, hypotonia, and respiratory depression. There is one reported case of neonatal death as the result of magnesium toxicity after transplacental exposure. The shortest duration of magnesium sulfate treatment that can lead to fetal harm is not known. Administration of Magnesium Sulfate in 5% Dextrose Injection beyond 5 to 7 days is not recommended. 5.2 Risk of Magnesium Toxicity Patients receiving Magnesium Sulfate in 5% Dextrose Injection are at risk for magnesium toxicity including respiratory depression, acute renal failure and rarely, pulmonary edema. Monitor clinical signs of magnesium toxicity (for example, facial edema, diminished strength of deep tendon reflexes, respiratory depression) and magnesium concentrations during infusions of Magnesium Sulfate in 5% Dextrose Injection. Clinical indications of a safe dosage regimen include the presence of the patellar reflex (knee jerk) and absence of respiratory depression (approximately 16 breaths or more per minute). Serum magnesium concentrations usually sufficient to control convulsions range from 3 to 6 mg per 100 mL (2.5 to 5 mEq per liter). The strength of the deep tendon reflexes begins to diminish when serum magnesium concentrations exceed 4 mEq per liter. Reflexes may be absent at concentration of 10 mEq per liter, at which point respiratory paralysis is a potential hazard. An injectable calcium salt should be immediately available to counteract the potential hazards of magnesium toxicity in patients with preeclampsia and eclampsia. If there is significant magnesium toxicity, stop the Magnesium Sulfate in 5% Dextrose Injection infusion and recheck serum magnesium concentration. Patients with renal impairment are at greater risk of magnesium toxicity because magnesium is excreted by the body solely by the kidneys [see Use in Specific Populations (8.6) ] . Urine output should be maintained at a level of 100 mL per 4 hours. Monitoring serum magnesium levels and the patient's clinical status is essential to avoid the consequences of overdosage in patients with preeclampsia. Discontinuation of the magnesium infusion is recommended when urine output is less than 100 mL every 4 hours to avoid magnesium toxicity, especially if serum creatinine is increasing progressively. 5.3 Risk of Elevated Blood Glucose Solutions containing dextrose should be used with caution in patients with known prediabetes or diabetes mellitus given the risk of elevated blood glucose. 5.4 Co-administration with Unapproved Tocolytics Do not use Magnesium Sulfate in 5% Dextrose Injection with unapproved tocolytics (e.g., beta adrenergic agents such as terbutaline, or with calcium channel blockers such as nifedipine). Serious adverse events including pulmonary edema and hypotension have occurred [see Drug Interactions (7) ] . 5.5 Aluminum Toxicity Magnesium Sulfate in 5% Dextrose Injection contains aluminum that may be toxic (Magnesium Sulfate in 5% Dextrose Injection contains less than 25 mcg/L of aluminum). Aluminum may reach toxic concentrations with prolonged parenteral administration in patients with renal impairment. Patients with renal impairment who receive parenteral concentrations of aluminum at greater than 4 to 5 mcg/kg/day, accumulate aluminum at concentrations associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. 5.6 Exacerbation of Myasthenia Gravis Magnesium Sulfate in 5% Dextrose Injection is contraindicated in patients with known myasthenia gravis. Use of magnesium sulfate in patients with underlying myasthenia gravis can precipitate a myasthenic crisis. Myasthenic crisis is a life-threatening condition characterized by neuromuscular respiratory failure. Symptoms of myasthenic crisis may include difficulty swallowing, ptosis, facial droop, weakness and/or difficulty breathing that may require intubation. If myasthenic crisis is suspected, discontinue use of Magnesium Sulfate in 5% Dextrose Injection immediately. Secure the patient's airway. Consider intensive care unit admission and elective intubation, if respiratory failure is anticipated. Once the airway is secure, confirm the diagnosis. Therapies include plasmapheresis and plasma exchange or intravenous immunoglobulin (IVIG) and immunomodulating therapy in addition to high-dose glucocorticoids."],"nonclinical_toxicology":["13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility."],"adverse_reactions_table":["
Cardiovascular:hypotension, circulatory collapse, cardiac depression including bradycardia
Central Nervous System:central nervous system depression leading to respiratory paralysis, visual disturbances, flushing, sweating, hypothermia
Metabolic:hypocalcemia with signs of tetany, hypermagnesemia
Neurologic:lethargy, sedation, somnolence, myasthenic crisis
Neuromuscular:depressed deep tendon reflexes, flaccid paralysis
Pulmonary:decreased respiratory rate, pulmonary edema
"],"drug_interactions_table":["Potentiation and prolongation of neuromuscular blockade is possible with the concomitant use of magnesium sulfate and neuromuscular blocking agents [see Clinical Pharmacology (12.2)].The underlying mechanism of this interaction may involve suppression of peripheral neuromuscular function by decreasing acetylcholine release, reduction of endplate sensitivity, and decreased muscle fiber excitability with magnesium sulfate therapy.Monitor respiration and the depth of neuromuscular blockade frequently (e.g., train-of-four monitoring) when a neuromuscular blocking agent is used concomitantly with Magnesium Sulfate in 5% Dextrose Injection.Adjust the dosage of the neuromuscular blocking agent accordingly to maintain the desired level of musculoskeletal activity. The amount of reversal agent(s) required to achieve adequate reversal of the neuromuscular blocking agent(s) may also be increased.Depolarizing neuromuscular blockers: succinylcholineNon-depolarizing neuromuscular blockers: atracurium, cisatracurium, pancuronium, rocuronium, vecuroniumPotentiation and prolongation of analgesia and CNS depression is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection with narcotics and/or propofol. The potential for magnesium sulfate to affect other CNS depressants is unknown [see Clinical Pharmacology (12.2)].The underlying mechanism of this interaction may involve antagonism of N-methyl-D-aspartate (NMDA) by magnesium sulfate therapy.Monitor the depth of CNS depression frequently using a reliable instrument.Adjust the narcotic and/or propofol dosage accordingly to maintain the desired level of analgesia and sedation.Narcotics and propofolAn exaggerated hypotensive response is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection with dihydropyridine calcium channel blockers. The potential for magnesium sulfate to affect other calcium channel blockers (e.g., diltiazem and verapamil) is unknown [see Clinical Pharmacology (12.2)].Monitor vital signs (heart rate, blood pressure, respiration) frequently.Supportive care and/or discontinuation of the calcium channel blocker may be required.Amlodipine, clevidipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, and nisoldipineReduced magnesium concentrations may impact efficacyMonitor magnesium concentrations frequently and adjust the Magnesium Sulfate in 5% Dextrose Injection dosage to maintain concentrations in the target range [see Dosage and Administration (2)].Alcohol, aminoglycosides, amphotericin B, cisplatin, cyclosporine, digitalis, loop diuretics, thiazide diuretics
Table 1: Potential Clinically Significant Drug Interactions with Magnesium Sulfate in 5% Dextrose InjectionFor drug incompatibility information [see Dosage and Administration (2.4)].
Neuromuscular Blocking Agents
Clinical Impact:
••
Intervention:
••
Examples:
••
Narcotics and/or Propofol
Clinical Impact:
••
Intervention:
••
Examples:
•
Dihydropyridine Calcium Channel Blockers
Clinical Impact:
•
Intervention:
••
Examples:
•
Drugs that May Induce Magnesium Loss
Clinical Impact:
•
Intervention:
•
Examples:
•
"],"information_for_patients":["17 PATIENT COUNSELING INFORMATION Magnesium Sulfate in 5% Dextrose Injection is typically administered to pregnancy women in emergent situations. When feasible, advise the patient and family of the following: Fetal-Neonatal Toxicity Reported With Prolonged Use Continuous administration of Magnesium Sulfate in 5% Dextrose Injection in pregnant women beyond 5 to 7 days can lead to hypocalcemia and bone abnormalities in the developing fetus, including skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported [see Warnings and Precautions (5.1) ] . Risk of Magnesium Toxicity Pregnant women receiving Magnesium Sulfate in 5% Dextrose Injection are at risk for magnesium toxicity, including facial edema, diminished strength of deep tendon reflexes, and respiratory depression [see Warnings and Precautions (5.2) ] ."],"spl_unclassified_section":["Distributed by Hospira, Inc., Lake Forest, IL 60045 USA LAB-1086-5.0 Logo"],"dosage_and_administration":["2 DOSAGE AND ADMINISTRATION • Administer via intravenous infusion pump ( 2.1 ) • Recommended loading dosage is 4 to 6 grams over 15 minutes followed by a recommended maintenance dosage of 1 to 2 grams every hour; maximum recommended dosage is 30 to 40 grams over 24 hours ( 2.2 ) • Obtain serum magnesium concentrations and assess clinical status to adjust the dose ( 2.2 ) • Administration beyond 5 to 7 days is not recommended ( 2.2 , 5.1 ) • In patients with severe renal impairment and/or urine output less than 0.5 mL/kg/hour, administer a 4 gram loading dose followed by a maintenance dosage of 1 gram every hour; do not exceed the maximum recommended dosage of 20 grams over 48 hours ( 2.3 ) • Do not administer Magnesium Sulfate in 5% Dextrose Injection with incompatible drugs through the same intravenous line, specifically with salicylates and alkali carbonates ( 2.4 ) 2.1 Important Administration Instructions Magnesium Sulfate in 5% Dextrose Injection is: • A clear solution. Visually inspect Magnesium Sulfate in 5% Dextrose Injection for particulate matter and discoloration prior to administration. Do not administer unless solution is clear and colorless to slightly yellow. • For intravenous use only • Administered via intravenous infusion pump Magnesium Sulfate in 5% Dextrose Injection does not require dilution prior to intravenous administration. After removing the overwrap, check for minute leaks by squeezing the container fully. Do not administer Magnesium Sulfate in 5% Dextrose Injection if there is a leak or there is greater than 2 mL of water in the overwrap [see Description (11) ]. Do not administer Magnesium Sulfate in 5% Dextrose Injection with incompatible drugs through the same intravenous line [see Dosage and Administration (2.4) ] . Do not use Magnesium Sulfate in 5% Dextrose Injection in series connections. 2.2 Recommended Dosage • The recommended loading dosage of Magnesium Sulfate in 5% Dextrose Injection in patients with eclampsia or preeclampsia is 4 to 6 grams over 15 minutes followed by a recommended maintenance dosage of 1 to 2 grams every hour. • Obtain serum magnesium concentrations and assess clinical status to adjust the dosage. • In patients with eclampsia, consider targeting the maintenance dosage to achieve serum magnesium concentrations of 3 to 6 mg per 100 mL (2.5 to 5 mEq per liter). For patients with recurrent eclampsia, consider giving an additional 2 gram intravenous bolus. • For patients with eclampsia, therapy should continue until seizures cease. • The maximum recommended dosage is 30 to 40 grams of magnesium sulfate over 24 hours. • Administration of Magnesium Sulfate in 5% Dextrose Injection beyond 5 to 7 days is not recommended [see Warnings and Precautions (5.1) ] . 2.3 Dosage in Patients with Severe Renal Impairment and/or Oliguria • In patients with severe renal impairment and/or a urine output less than 0.5 mL/kg/hour, initiate Magnesium Sulfate in 5% Dextrose Injection with a 4 gram loading dose followed by a maintenance dosage of 1 gram every hour. • Titrate the magnesium sulfate maintenance dosage to maintain concentrations in the target range through frequent monitoring of magnesium concentrations and observation for clinical signs of magnesium toxicity (e.g., facial edema, diminished strength of deep tendon reflexes, respiratory depression). A lower maintenance dosage requirement is likely in these patients. • Do not exceed the maximum recommended dosage of 20 grams of Magnesium Sulfate in 5% Dextrose Injection over 48 hours. 2.4 Drug Incompatibilities Magnesium Sulfate in 5% Dextrose Injection is not compatible with administration of a variety of solutions and forms precipitates of magnesium salts. Before using Magnesium Sulfate in 5% Dextrose Injection with another parenteral product, investigate potential incompatibilities. Incompatible products that should not be coadministered include salicylates and alkali carbonates."],"spl_product_data_elements":["Magnesium Sulfate in Dextrose Magnesium Sulfate in Dextrose MAGNESIUM SULFATE HEPTAHYDRATE MAGNESIUM CATION SULFURIC ACID SODIUM HYDROXIDE DEXTROSE MONOHYDRATE WATER"],"dosage_forms_and_strengths":["3 DOSAGE FORMS AND STRENGTHS Magnesium Sulfate in 5% Dextrose Injection, USP is a clear and colorless to slightly yellow solution supplied in single-dose flexible plastic containers: • 0.01 grams per mL (1%): ▪ 100 mL flexible plastic container containing 1 gram of magnesium sulfate in 5% dextrose injection Each 100 mL contains 5 grams of hydrous dextrose in Water for Injection. Supplied in premixed single-dose flexible plastic containers: ( 3 ) • 0.01 grams/mL (1%) in 100 mL flexible plastic container containing 1 gram of magnesium sulfate in 5% dextrose injection"],"use_in_specific_populations":["8 USE IN SPECIFIC POPULATIONS Patients with severe renal impairment and/or a urine output less than 100 mL every 4 hours are at greater risk for increased magnesium concentrations that may lead to toxicity ( 8.6 ) 8.1 Pregnancy Risk Summary Magnesium Sulfate in 5% Dextrose Injection is indicated in pregnant women for the prevention of eclampsia in women with preeclampsia and the treatment of seizures and prevention of recurrent seizures in women with eclampsia. Fetal, neonatal, and maternal risks are discussed throughout the labeling. Clinical Considerations Labor or Delivery: Magnesium Sulfate in 5% Dextrose Injection is not approved for the treatment of pre-term labor. Administration of Magnesium Sulfate in 5% Dextrose Injection to pregnant women longer than 5 to 7 days may lead to hypocalcemia and bone abnormalities in the developing fetus, including skeletal demineralization and osteopenia [see Warnings and Precautions (5.1) ] . 8.2 Lactation The use of intravenous magnesium in pregnant women increases human milk magnesium concentrations only slightly and oral absorption of magnesium by the infant is poor. The effect of intravenous magnesium on milk production is unknown. The developmental and health benefits to the neonate of breastfeeding should be considered along with the mother's clinical need for Magnesium Sulfate in 5% Dextrose Injection and any potential adverse effects on the breastfed infant from Magnesium Sulfate in 5% Dextrose Injection or from the underlying maternal condition. 8.4 Pediatric Use The safety and effectiveness of Magnesium Sulfate in 5% Dextrose Injection have been established for the prevention of eclampsia in adolescents with preeclampsia and the treatment of seizures and prevention of recurrent seizures in adolescents with eclampsia. Dosing recommendation in pregnant adolescent patients are the same as for pregnant adult patients [see Dosage and Administration (2.2) ] . 8.6 Renal Impairment Magnesium is excreted solely by the kidneys. Patients with severe renal impairment (urine output less than 100 mL per 4 hours) are at greater risk for increased magnesium concentrations that may lead to magnesium toxicity [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3) ] . In patients with severe renal impairment, dosage reduction is recommended and the maximum recommended dosage is lower than patients with normal renal function [see Dosage and Administration (2.3) ] ."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 100 mL Bag Label 100 mL NDC 0409-6727-55 Magnesium Sulfate in 5% Dextrose Injection, USP 1 g/100 mL (10 mg/mL) 1g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 1 g (equivalent to 8.1 mEq magnesium) and dextrose, hydrous 5 g in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 333 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended Dosage: See Prescribing Information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Rx ONLY 12166-05 5 PP MADE IN CZECH REPUBLIC Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira LOT:12345678 EXP: YYYY-MMM PRINCIPAL DISPLAY PANEL - 100 mL Bag Label","PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap 100 mL NDC 0409-6727-55 Magnesium Sulfate in 5% Dextrose Injection, USP 1 g/100 mL (10 mg/mL) 1g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 1 g (equivalent to 8.1 mEq magnesium) and dextrose, hydrous 5 g in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 333 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5.) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx Only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13089-01 PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap"],"carcinogenesis_and_mutagenesis_and_impairment_of_fertility":["13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility."]},"tags":[{"label":"magnesium sulfate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A06AD04","category":"atc"},{"label":"Topical","category":"route"},{"label":"Oral","category":"route"},{"label":"Intravenous","category":"route"},{"label":"Capsule","category":"form"},{"label":"Crystal","category":"form"},{"label":"Granule","category":"form"},{"label":"Injection","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic 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Dosing recommendation in pregnant adolescent patients are the same as for pregnant adult patients [see Dosage and Administration (2.2) ] .","Pregnancy":"8.1 Pregnancy Risk Summary Magnesium Sulfate in 5% Dextrose Injection is indicated in pregnant women for the prevention of eclampsia in women with preeclampsia and the treatment of seizures and prevention of recurrent seizures in women with eclampsia. Fetal, neonatal, and maternal risks are discussed throughout the labeling. Clinical Considerations Labor or Delivery: Magnesium Sulfate in 5% Dextrose Injection is not approved for the treatment of pre-term labor. Administration of Magnesium Sulfat","Specific Populations":"8 USE IN SPECIFIC POPULATIONS Patients with severe renal impairment and/or a urine output less than 100 mL every 4 hours are at greater risk for increased magnesium concentrations that may lead to toxicity ( 8.6 ) 8.1 Pregnancy Risk Summary Magnesium Sulfate in 5% Dextrose Injection is indicated in pregnant women for the prevention of eclampsia in women with preeclampsia and the treatment of seizures and prevention of recurrent seizures in women with eclampsia. Fetal, neonatal, and maternal risk"},"seriousAdverseEvents":[]},"company":"Pfizer","patents":[],"_sources":{"fdaNDC":{"url":"","method":"api_direct","source":"FDA NDC Directory","rawText":"","confidence":1,"sourceType":"fda_ndc","retrievedAt":"2026-04-19T19:03:49.551492+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book + Purple Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-19T19:04:04.411799+00:00"},"dailyMed":{"url":"","method":"api_direct","source":"DailyMed (NIH/NLM)","rawText":"","confidence":1,"sourceType":"dailymed","retrievedAt":"2026-04-19T19:03:50.287372+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"Haiku strategic summary","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T07:54:34.468756+00:00"},"mechanism":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T08:24:54.543122+00:00"},"chemblData":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3989857/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T19:03:57.306321+00:00"},"fdaRecalls":{"url":"","method":"api_direct","source":"FDA Enforcement/Recalls","rawText":"","confidence":1,"sourceType":"fda_enforcement","retrievedAt":"2026-04-19T19:03:55.556309+00:00"},"overdosage":{"url":"","method":"deterministic","source":"FDA Label (overdosage)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-19T19:03:05.521089+00:00"},"howSupplied":{"url":"","method":"deterministic","source":"FDA Label (how_supplied)","rawText":"16 HOW SUPPLIED/STORAGE AND HANDLING Magnesium Sulfate in 5% Dextrose Injection, USP is a clear solution supplied in single-dose flexible plastic containers (see Table 2 ). Table 2: How Supplied Information NDC Number (Unit of Sale) Concentration Total Magnesium Sulfate As the heptahydrate; Total Magnesium Ion Magnesium Sulfate Concentration Magnesium Ion Concentration Osmolarity Osmolarity was calculated. NDC 0409-6727-23 Case of 24 single-dose flexible plastic containers 1 g/100 mL (10 mg/mL) ","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-19T19:02:47.335061+00:00"},"trialDetails":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials with endpoints)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:04:16.780166+00:00"},"drugDescription":{"url":"","method":"ai_extraction","source":"FDA Label (description)","aiModel":"featherless","rawText":"11 DESCRIPTION Magnesium Sulfate in 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate and dextrose in water for injection for intravenous use. Each 100 mL contains 1 gram of magnesium sulfate heptahydrate and dextrose, hydrous 5 grams in water for injection [see How Supplied/Storage and Handling (16) ] . Magnesium Sulfate in 5% Dextrose Injection, USP may contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). Ma","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-19T19:03:05.521012+00:00"},"pharmacokinetics":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T08:24:54.543142+00:00"},"publicationCount":{"url":"","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T19:03:55.678887+00:00"},"faersTotalReports":{"url":"","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-19T19:03:55.170038+00:00"},"recentPublications":{"url":"","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T19:03:56.628251+00:00"},"rxnormFormulations":{"url":"https://rxnav.nlm.nih.gov/REST/drugs.json?name=Magnesium Sulfate","method":"api_direct","source":"RxNorm (NIH)","rawText":"","confidence":1,"sourceType":"rxnorm","retrievedAt":"2026-04-19T19:03:49.028503+00:00"},"participantFlowData":{"url":"","method":"deterministic","source":"ClinicalTrials.gov participantFlowModule","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:04:16.780098+00:00"},"safety.safetySignals":{"url":"","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-19T19:03:51.211319+00:00"},"mechanism.oneSentence":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku extraction","aiModel":"claude-haiku-4-5","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T07:54:34.468714+00:00"},"nonclinicalToxicology":{"url":"","method":"deterministic","source":"FDA Label (nonclinical_toxicology)","rawText":"13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility.\n13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility.","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-19T19:03:05.521084+00:00"},"structuredTrialResults":{"url":"","method":"deterministic","source":"ClinicalTrials.gov resultsSection (0 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:04:16.780096+00:00"},"safety.drugInteractions":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T07:54:34.468752+00:00"},"safety.commonSideEffects":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials with results)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:04:16.780058+00:00"},"safety.contraindications":{"url":"","method":"ai_extraction","source":"FDA Label + Haiku","rawText":"","confidence":0.95,"sourceType":"fda_label","retrievedAt":"2026-04-20T07:54:34.468745+00:00"},"safety.specialPopulations":{"url":"","method":"deterministic","source":"FDA Label (special populations)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-19T19:03:33.060746+00:00"},"safety.seriousAdverseEvents":{"url":"","method":"deterministic","source":"ClinicalTrials.gov (0 trials)","rawText":"","confidence":1,"sourceType":"ctgov_results","retrievedAt":"2026-04-19T19:04:16.780080+00:00"}},"allNames":["magnesium sulfate","sulfuric acid magnesium salt","epsom salt","magnesium sulphate","magnesium sulfate heptahydrate","magnesium sulfate, unspecified","magnesium sulfate anhydrous"],"dailyMed":[{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9da4121f-d62d-4da4-8dfb-0494da16015f","setid":"9da4121f-d62d-4da4-8dfb-0494da16015f","title":"TIS-U-SOL (SODIUM CHLORIDE, POTASSIUM CHLORIDE, MAGNESIUM SULFATE, SODIUM PHOSPHATE, AND POTASSIUM PHOSPHATE) IRRIGANT [BAXTER HEALTHCARE CORPORATION]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f269929e-c2ff-4288-9d3b-7770bcb5a498","setid":"f269929e-c2ff-4288-9d3b-7770bcb5a498","title":"SODIUM SULFATE, POTASSIUM SULFATE AND MAGNESIUM SULFATE (SODIUM SULFATE, POTASSIUM SULFATE, MAGNESIUM SULFATE) SOLUTION, CONCENTRATE [WILSHIRE PHARMACEUTICALS, INC.]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31d13799-0931-7735-e063-6294a90a6d02","setid":"31d13799-0931-7735-e063-6294a90a6d02","title":"SODIUM SULFATE, POTASSIUM SULFATE, AND MAGNESIUM SULFATE SOLUTION [BIONPHARMA INC.,]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=50f23abd-6a66-44cb-960e-d43c16a5ae5f","setid":"50f23abd-6a66-44cb-960e-d43c16a5ae5f","title":"SUPREP BOWEL PREP (SODIUM SULFATE, POTASSIUM SULFATE, MAGNESIUM SULFATE) SOLUTION, CONCENTRATE [AZURITY PHARMACEUTICALS, INC.]"},{"url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c020e973-dccf-4862-999e-17db6209a48a","setid":"c020e973-dccf-4862-999e-17db6209a48a","title":"SUTAB (SODIUM SULFATE, MAGNESIUM SULFATE, AND POTASSIUM CHLORIDE) TABLET [AZURITY PHARMACEUTICALS, INC.]"}],"synonyms":["magnesium sulfate","sulfuric acid magnesium salt","epsom salt","magnesium sulphate","magnesium sulfate heptahydrate","magnesium sulfate, unspecified","magnesium sulfate anhydrous"],"timeline":[{"date":"19960927","type":"positive","_source":"FDA NDA020577","milestone":"FDA ORIG — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"19971202","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"19980522","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20000425","type":"positive","_source":"FDA ANDA075151","milestone":"FDA ORIG — HOSPIRA","regulator":"FDA","description":""},{"date":"20001117","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20040823","type":"positive","_source":"FDA ANDA075151","milestone":"FDA SUPPL — HOSPIRA","regulator":"FDA","description":""},{"date":"20121214","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20121217","type":"positive","_source":"FDA ANDA075151","milestone":"FDA SUPPL — HOSPIRA","regulator":"FDA","description":""},{"date":"20140718","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20150514","type":"positive","_source":"FDA ANDA202411","milestone":"FDA ORIG — HOSPIRA","regulator":"FDA","description":""},{"date":"20150611","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20151026","type":"positive","_source":"FDA ANDA075151","milestone":"FDA SUPPL — HOSPIRA","regulator":"FDA","description":""},{"date":"20160302","type":"positive","_source":"FDA ANDA207349","milestone":"FDA ORIG — HQ SPCLT PHARMA","regulator":"FDA","description":""},{"date":"20160307","type":"positive","_source":"FDA ANDA206486","milestone":"FDA ORIG — FRESENIUS KABI USA","regulator":"FDA","description":""},{"date":"20161125","type":"positive","_source":"FDA ANDA207349","milestone":"FDA SUPPL — HQ SPCLT PHARMA","regulator":"FDA","description":""},{"date":"20161129","type":"positive","_source":"FDA NDA020577","milestone":"FDA SUPPL — LUKARE MEDICAL LLC","regulator":"FDA","description":""},{"date":"20171206","type":"positive","_source":"FDA ANDA207350","milestone":"FDA ORIG — HQ SPCLT PHARMA","regulator":"FDA","description":""},{"date":"20190311","type":"positive","_source":"FDA ANDA202411","milestone":"FDA SUPPL — HOSPIRA","regulator":"FDA","description":""},{"date":"20191127","type":"positive","_source":"FDA ANDA207349","milestone":"FDA SUPPL — HQ SPCLT PHARMA","regulator":"FDA","description":""},{"date":"20200601","type":"positive","_source":"FDA ANDA211966","milestone":"FDA ORIG — BAXTER HLTHCARE CORP","regulator":"FDA","description":""},{"date":"20220510","type":"positive","_source":"FDA ANDA211965","milestone":"FDA SUPPL — BAXTER HLTHCARE CORP","regulator":"FDA","description":""},{"date":"20240624","type":"positive","_source":"FDA ANDA204135","milestone":"FDA ORIG — BIONPHARMA","regulator":"FDA","description":""},{"date":"20250528","type":"positive","_source":"FDA ANDA219777","milestone":"FDA ORIG — ASPIRO","regulator":"FDA","description":""},{"date":"20260108","type":"positive","_source":"FDA ANDA211966","milestone":"FDA SUPPL — BAXTER HLTHCARE CORP","regulator":"FDA","description":""}],"variants":[{"slug":"magnesium-sulfate-in-dextrose-5-in-plastic-container","route":"","brandName":"Magnesium Sulfate In Dextrose 5% In Plastic Container","description":"Magnesium Sulfate In Dextrose 5% In Plastic Container","formulation":"{2 (480 ML) (magnesium sulfate 0.0277 MEQ/ML / potassium sulfate 0.0374 MEQ/ML / sodium sulfate 0.257 MEQ/ML Oral Solution) } Pack [Suprep Bowel Prep Kit]; {2 (355 ML) (magnesium sulfate 0.0277 MEQ/ML / potassium sulfate 0.0374 MEQ/ML / sodium sulfate 0.257 MEQ/ML Oral Solution) } Pack [Suprep Pediatric Bowel Prep Kit]; {2 (magnesium sulfate 900 MG / polyethylene glycol 3350 179000 MG / potassium chloride 1120 MG / sodium chloride 500 MG / sodium sulfate 7300 MG Powder for Oral Solution) } Pack [Suflave]"}],"aiSummary":"Magnesium Sulfate in 5% Dextrose Injection is indicated for prevention of eclampsia in preeclampsia and treatment/prevention of seizures in eclampsia. The drug blocks neuromuscular transmission and decreases acetylcholine release with a half-life of 4-5 hours and renal excretion. Major contraindications include heart block, myocardial damage, diabetic coma, and myasthenia gravis; significant interactions exist with neuromuscular blocking agents and CNS depressants. Careful monitoring is required in renal impairment and when used concomitantly with other medications affecting neuromuscular function.","brandName":"Magnesium Sulfate","ecosystem":[{"indication":"Constipation","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"glycerol","slug":"glycerol","company":"B Braun"}],"globalPrevalence":null},{"indication":"Eclampsia in pregnancy","otherDrugs":[],"globalPrevalence":null},{"indication":"Hypomagnesemia","otherDrugs":[{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"},{"name":"magnesium chloride","slug":"magnesium-chloride","company":"Hospira"},{"name":"magnesium oxide","slug":"magnesium-oxide","company":"Baxter Hlthcare"}],"globalPrevalence":null},{"indication":"Incomplete passage of stool","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"homatropine","slug":"homatropine","company":""},{"name":"macrogol","slug":"macrogol","company":"Braintree"}],"globalPrevalence":null},{"indication":"Mild pre-eclampsia","otherDrugs":[],"globalPrevalence":null},{"indication":"Severe pre-eclampsia","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Neuromuscular junction; motor nerve impulse; acetylcholine release","novelty":"Follow-on","modality":"Small molecule electrolyte","drugClass":"Electrolyte; anticonvulsant","explanation":"Magnesium prevents seizures in patients with preeclampsia and controls seizures in patients with eclampsia by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium has a depressant effect on the central nervous system. Magnesium acts peripherally to produce vasodilation.","oneSentence":"Magnesium blocks neuromuscular transmission and decreases acetylcholine release, preventing seizures in preeclampsia and eclampsia.","technicalDetail":"Magnesium blocks neuromuscular transmission by inhibiting the release of acetylcholine at the neuromuscular junction. It also has a depressant effect on the central nervous system, likely through interactions with NMDA receptors and other ion channels."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Magnesium_sulfate","title":"Magnesium sulfate","extract":"Magnesium sulfate or magnesium sulphate is a chemical compound, a salt with the formula MgSO4, consisting of magnesium cations Mg2+ (20.19% by mass) and sulfate anions SO2−4. It is a white crystalline solid, soluble in water."},"chemblData":{"prodrug":0,"chemblId":"CHEMBL3989857","maxPhase":"4.0","chirality":2,"parenteral":true,"availability":1,"moleculeType":"Small molecule","withdrawnFlag":false,"naturalProduct":0,"blackBoxWarning":0,"oralBioavailable":true},"commercial":{"launchDate":"1981","annualCostUS":"$0.00/yr or empty","_launchSource":"DrugCentral (FDA 1981-10-06, BAXTER HLTHCARE)","genericStatus":"Generic — off-patent","currentRevenue":"$0.00B or empty","manufacturerCount":"7 approved manufacturers","patientPopulation":"~0M or empty","peakSalesEstimate":"$0.00B or empty"},"fdaRecalls":[{"date":"20120405","reason":"Superpotent (Single Ingredient) Drug: Above specification assay results for percentage of magnesium sulfate.","status":"Terminated","distribution":"Nationwide","classification":"Class III"},{"date":"20160105","reason":"Labeling: Incorrect Barcode: Primary bag labeling may be mislabeled with the wrong barcode which scans in as heparin sodium.","status":"Terminated","distribution":"Nationwide","classification":"Class I"},{"date":"20260318","reason":"Product mix up: An IV bag, contained within a labeled Magnesium Sulfate in Water for Injection, 4 g/100 mL foil pouch, was identified as Tranexamic Acid","status":"Ongoing","distribution":"U.S.A. Nationwide","classification":"Not Yet Classified"},{"date":"20150306","reason":"Labeling: Wrong Bar Code: There is a potential for some units to be mislabeled with an incorrect barcode on the immediate container that scans as heparin sodium 2000 USP units/1000 mL in 0.9% in sodium chloride injection.","status":"Terminated","distribution":"Nationwide","classification":"Class I"},{"date":"20181003","reason":"Correct Labeled Product Mispack: confirmed report involving a single unit of properly labeled Heparin in 0.45% Sodium Chloride for Injection (NDC 0409-7651-03, Lot 87903FW) that was found inside a case of Magnesium Sulfate in Water for Injection.","status":"Terminated","distribution":"Nationwide in the USA and Puerto Rico","classification":"Class II"}],"overdosage":"10 OVERDOSAGE Manifestations of magnesium toxicity include a drop in blood pressure, difficulty breathing, and disappearance of the patellar reflex. As serum magnesium rises above 4 mEq per liter, the deep tendon reflexes decrease. As the serum magnesium level approaches 10 mEq per liter, the tendon reflexes disappear and respiratory paralysis may occur [see Warnings and Precautions (5.2) ] . Other signs and symptoms of magnesium overdosage include flushing, sweating, hypotension, weakness, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis, cardiac arrest, and prolongation of PR and QRS intervals. Patients with renal impairment and underlying neuromuscular diseases such as myasthenia gravis may experience magnesium intoxication at lower magnesium concentrations (Magnesium Sulfate in 5% Dextrose Injection is contraindicated in patients with myasthenia gravis). If patient is experiencing magnesium toxicity, immediately di","references":[{"id":1,"url":"https://drugcentral.org/drugcard/4290","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Magnesium%20Sulfate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Magnesium Sulfate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Magnesium_sulfate","fields":["history","overview"],"source":"Wikipedia"},{"id":5,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T01:39:34.440514","_validation":{"fieldsValidated":5,"lastValidatedAt":"2026-04-20T08:24:57.806814+00:00","fieldsConflicting":0,"overallConfidence":0.95},"competitors":[{"name":"Terbutaline","company":"Generic","advantage":"Beta adrenergic agent that can be used as an unapproved tocolytic, competing with Magnesium Sulfate in Dextrose 5% In Plastic Container for prevention of preterm labor"},{"name":"Calcium Channel Blockers (Dihydropyridine)","company":"Generic","advantage":"Can cause an exaggerated hypotensive response when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Narcotics","company":"Generic","advantage":"Can potentiate and prolong analgesia and CNS depression when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Propofol","company":"Generic","advantage":"Can potentiate and prolong analgesia and CNS depression when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Alcohol","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Aminoglycosides","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Amphotericin B","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Cisplatin","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Cyclosporine","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Digitalis","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Loop Diuretics","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Thiazide Diuretics","company":"Generic","advantage":"Can induce magnesium loss when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Salicylates","company":"Generic","advantage":"Can form precipitates of magnesium salts when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"},{"name":"Alkali Carbonates","company":"Generic","advantage":"Can form precipitates of magnesium salts when used concomitantly with Magnesium Sulfate in Dextrose 5% In Plastic Container"}],"dataSources":[{"url":"https://tavily.com","name":"Tavily AI Search","fields":["latestUpdates"],"retrievedDate":"2026-04-07"},{"url":"https://jina.ai/reader","name":"Jina Reader","fields":["commercialAnalysis"],"retrievedDate":"2026-04-07"},{"url":"https://groq.com","name":"Groq (Llama 3.1 8B)","fields":["commercialAnalysis"],"retrievedDate":"2026-04-07"}],"genericName":"magnesium sulfate","howSupplied":"16 HOW SUPPLIED/STORAGE AND HANDLING Magnesium Sulfate in 5% Dextrose Injection, USP is a clear solution supplied in single-dose flexible plastic containers (see Table 2 ). Table 2: How Supplied Information NDC Number (Unit of Sale) Concentration Total Magnesium Sulfate As the heptahydrate; Total Magnesium Ion Magnesium Sulfate Concentration Magnesium Ion Concentration Osmolarity Osmolarity was calculated. NDC 0409-6727-23 Case of 24 single-dose flexible plastic containers 1 g/100 mL (10 mg/mL) 1 g 8.1 mEq 0.01 g/mL (1%) 8.1 mEq/100 mL 333 mOsmol/liter NDC 0409-6727-50 Case of 50 single-dose flexible plastic containers 1 g/100 mL (10 mg/mL) 1 g 8.1 mEq 0.01 g/mL (1%) 8.1 mEq/100 mL 333 mOsmol/liter Storage Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.","indications":{"approved":[{"name":"Constipation","source":"DrugCentral","snomedId":14760008,"regulator":"FDA","eligibility":"Adults and children 6 years of age and older"},{"name":"Eclampsia in pregnancy","source":"DrugCentral","snomedId":198992004,"regulator":"FDA","eligibility":"Pregnant women with eclampsia"},{"name":"Hypomagnesemia","source":"DrugCentral","snomedId":190855004,"regulator":"FDA","eligibility":"Not specified"},{"name":"Incomplete passage of stool","source":"DrugCentral","snomedId":249515001,"regulator":"FDA","eligibility":"Not specified"},{"name":"Mild pre-eclampsia","source":"DrugCentral","snomedId":41114007,"regulator":"FDA","eligibility":"Pregnant women with mild pre-eclampsia"},{"name":"Severe pre-eclampsia","source":"DrugCentral","snomedId":46764007,"regulator":"FDA","eligibility":"Pregnant women with severe pre-eclampsia"}],"offLabel":[{"name":"Atypical Ventricular Tachycardia","source":"DrugCentral","drugName":"Magnesium Sulfate","evidenceCount":1,"evidenceLevel":"emerging"},{"name":"Torsades de pointes","source":"DrugCentral","drugName":"Magnesium Sulfate","evidenceCount":119,"evidenceLevel":"strong"}],"pipeline":[]},"isCanonical":true,"currentOwner":"Hospira","drugCategory":"established","patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"magnesium-carbonate","brandName":"magnesium carbonate","genericName":"magnesium carbonate","approvalYear":"1990","relationship":"same-class"},{"drugId":"magnesium-oxide","brandName":"magnesium oxide","genericName":"magnesium oxide","approvalYear":"1982","relationship":"same-class"},{"drugId":"lactulose","brandName":"lactulose","genericName":"lactulose","approvalYear":"1976","relationship":"same-class"},{"drugId":"lactitol","brandName":"lactitol","genericName":"lactitol","approvalYear":"2020","relationship":"same-class"},{"drugId":"sodium-sulfate","brandName":"sodium sulfate","genericName":"sodium sulfate","approvalYear":"1986","relationship":"same-class"},{"drugId":"macrogol","brandName":"macrogol","genericName":"macrogol","approvalYear":"1984","relationship":"same-class"},{"drugId":"mannitol","brandName":"mannitol","genericName":"mannitol","approvalYear":"1964","relationship":"same-class"},{"drugId":"sodium-phosphate","brandName":"sodium phosphate","genericName":"sodium phosphate","approvalYear":"1983","relationship":"same-class"},{"drugId":"sorbitol","brandName":"sorbitol","genericName":"sorbitol","approvalYear":"1971","relationship":"same-class"},{"drugId":"magnesium-citrate","brandName":"magnesium citrate","genericName":"magnesium citrate","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"whoEssential":true,"latestUpdates":[{"url":"https://www.grandviewresearch.com/industry-analysis/magnesium-sulfate-market-report","date":"2026-04-07","type":"news","title":"Magnesium Sulfate Market Size, Share | Industry Report ...","source":"www.grandviewresearch.com"},{"url":"https://www.factmr.com/report/4184/magnesium-sulphate-market","date":"2026-04-07","type":"news","title":"Magnesium Sulphate Market (2025 - 2035)","source":"www.factmr.com"},{"url":"https://straitsresearch.com/report/magnesium-sulfate-market","date":"2026-04-07","type":"news","title":"Magnesium Sulfate Market Size, Share & Trends Report by ...","source":"straitsresearch.com"},{"url":"https://www.pfizerhospitalus.com/sites/default/files/news_announcements/Mag%20Sulfate%2040g1000ml%20NDC%20Update.pdf","date":"2026-04-07","type":"news","title":"Pfizer Inc. 275 North Field Drive Lake ...","source":"www.pfizerhospitalus.com"},{"url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019316s024lbl.pdf","date":"2026-04-07","type":"news","title":"[PDF] Magnesium Sulfate Injection, USP 50% - accessdata.fda.gov","source":"www.accessdata.fda.gov"}],"manufacturing":[{"role":"Manufacturer","site":"Hospira, Inc.","location":"","operator":"Hospira, Inc."}],"administration":{"route":"Topical, Oral, Intravenous","formulation":"Capsule, Crystal, Granule, Injection","formulations":[{"form":"CAPSULE","route":"ORAL","productName":"Dexatran"},{"form":"CRYSTAL","route":"ORAL","productName":"Epsom Salt"},{"form":"GRANULE","route":"ORAL","productName":"NuValu Epsom Salt"},{"form":"GRANULE","route":"ORAL","productName":"Assured Epsom Salt"},{"form":"GRANULE","route":"ORAL","productName":"Daily Care Epsom Salt"},{"form":"GRANULE","route":"ORAL","productName":"Epsom Salt"},{"form":"GRANULE","route":"ORAL","productName":"Epsom Salts"},{"form":"GRANULE","route":"ORAL","productName":"Epsom SaltsRelief"},{"form":"GRANULE","route":"ORAL","productName":"Relief Epsom Salt"},{"form":"GRANULE, FOR SOLUTION","route":"ORAL","productName":"Epsom Salt"},{"form":"GRANULE, FOR SOLUTION","route":"ORAL","productName":"Harmon Core Values Epsom Salt"},{"form":"GRANULE, FOR SOLUTION","route":"ORAL","productName":"epsom salt"},{"form":"GRANULE, FOR SOLUTION","route":"TOPICAL","productName":"Epsom Salt"},{"form":"INJECTION","route":"INTRAVENOUS","productName":"Magnesium Sulfate"},{"form":"INJECTION, EMULSION","route":"INTRAVENOUS","productName":"Kabiven"}]},"_patentsChecked":true,"crossReferences":{"NUI":"N0000147424","MMSL":"173828","NDDF":"000789","UNII":"SK47B8698T","VUID":"4019181","CHEBI":"CHEBI:32599","VANDF":"4000969","RXNORM":"1053346","UMLSCUI":"C0024480","chemblId":"CHEMBL3989857","ChEMBL_ID":"CHEMBL2021423","DRUGBANK_ID":"DB00653","PUBCHEM_CID":"24083","SNOMEDCT_US":"1269139001","SECONDARY_CAS_RN":"10034-99-8","MESH_DESCRIPTOR_UI":"D008278"},"drugDescription":{"pH":"4.5 (3.5 to 6.5)","structure":"Colorless crystals or white powder (Magnesium Sulfate Heptahydrate), Hexose sugar freely soluble in water (Dextrose Monohydrate)","appearance":"Colorless crystals or white powder (Magnesium Sulfate Heptahydrate), Freely soluble in water (Dextrose Monohydrate)","composition":"Each 100 mL contains 1 gram of magnesium sulfate heptahydrate and 5 grams of dextrose, hydrous in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment.","molecularWeight":"246.47 g/mol (Magnesium Sulfate Heptahydrate), 198.17 g/mol (Dextrose Monohydrate)","molecularFormula":"MgSO4 ∙ 7H2O (Magnesium Sulfate Heptahydrate), C6H12O6 ∙ H2O (Dextrose Monohydrate)"},"originalProduct":{"form":"IRRIGANT","route":"IRRIGATION","company":"Baxter Healthcare Corporation","brandName":"TIS-U-SOL","isOriginal":true,"marketingStatus":"NDA"},"_enricherVersion":"v2","_offLabelChecked":true,"chemblMechanisms":[{"actionType":null,"targetChemblId":null,"mechanismComment":null,"mechanismOfAction":"Unknown"}],"ownershipHistory":[{"period":"1981-","companyName":"Baxter Hlthcare","relationship":"Original Developer"},{"period":"present","companyName":"Pfizer","relationship":"Current Owner"},{"period":"2021","companyName":"Nihon Pharmaceutical Co., Ltd.","relationship":"PMDA Licensee"}],"pharmacokinetics":{"tmax":"","halfLife":"4 to 5 hours","clearance":"4 to 5 liters per hour","excretion":"Solely by the kidney at a rate proportional to serum concentration and glomerular filtration","metabolism":"","proteinBinding":"30% bound to albumin","bioavailability":"","volumeOfDistribution":"Approximately 1 to 2% of total body magnesium located in extracellular fluid space"},"publicationCount":5139,"atcClassification":{"source":"DrugCentral","atcCode":"A06AD04","allCodes":["A06AD04","A12CC02","B05XA05","D11AX05","V04CC02"]},"faersTotalReports":19194,"originalDeveloper":"Baxter Hlthcare","commercialAnalysis":{"text":"Pfizer's Magnesium Sulfate has established itself as a prominent player in the market, with a strong presence across various indications such as constipation, eclampsia in pregnancy, hypomagnesemia, incomplete passage of stool, and mild pre-eclampsia. According to a report by Grand View Research, the global magnesium sulfate market size is expected to reach USD 1.59 billion by 2035, growing at a CAGR of 5.7% [1]. This growth is driven by escalating demand for agricultural nutrients and expanding pharmaceutical production infrastructure across regulated markets.\n\nThe competitive landscape of the magnesium sulfate market is relatively fragmented, with several players vying for market share. However, Pfizer's Magnesium Sulfate has a strong brand presence and is widely recognized for its efficacy and safety profile. According to a report by Straits Research, the global magnesium sulfate market size was estimated at USD 971.49 million in 2025 and is projected to reach USD 1,592.27 million by 2034, growing at a CAGR of 5.6% [2]. This growth is driven by a consistently expanding pharmaceutical industry and strategic investments in research and development.\n\nLooking ahead, the market is expected to be influenced by several key catalysts. The patent cliff for several magnesium sulfate products is expected to occur in the next few years, which could lead to increased competition and pricing pressure. Additionally, label expansions and pipeline competitors could also impact the market dynamics. According to a report by FactMR, the global magnesium sulphate market is set to grow from USD 0.91 billion in 2025 to USD 1.59 billion by 2035, adding USD 0.68 billion in new revenue and advancing at a CAGR of 5.7% [3].\n\nOverall, Pfizer's Magnesium Sulfate is well-positioned to capitalize on the growing demand for magnesium sulfate products. However, the company will need to continue to innovate and differentiate its products to maintain its market share in the face of increasing competition.\n\nReferences:\n[1] Grand View Research, \"Magnesium Sulfate Market Size, Share | Industry Report 2025-2035\"\n[2] Straits Research, \"Magnesium Sulfate Market Size, Share & Trends Analysis Report By Type, By Form, By End Use, and By Region Forecasts, 2026-2034\"\n[3] FactMR, \"Magnesium Sulphate Market (2025 - 2035)\"","model":"llama-3.1-8b (Groq)","sources":[{"url":"https://www.grandviewresearch.com/industry-analysis/magnesium-sulfate-market-report","date":"","title":"Magnesium Sulfate Market Size, Share | Industry Report ...","source":"www.grandviewresearch.com"},{"url":"https://www.factmr.com/report/4184/magnesium-sulphate-market","date":"","title":"Magnesium Sulphate Market (2025 - 2035)","source":"www.factmr.com"},{"url":"https://straitsresearch.com/report/magnesium-sulfate-market","date":"","title":"Magnesium Sulfate Market Size, Share & Trends Report by ...","source":"straitsresearch.com"}],"disclaimer":"AI-generated analysis based on public sources. 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sulfate 6.9 MG / manganese sulfate 1.3 MG / niacin 20 MG / polysaccharide iron complex 92.4 MG / pyridoxine hydrochloride 25 MG / riboflavin 5 MG / thiamine mononitrate 5 MG / vitamin B12 0.01 MG / zinc sulfate 18.2 MG Oral Capsule","rxcui":"1314666","synonym":"vit-C 210 MG / biotin 0.3 MG / calcium pantothenate 7 MG / copper sulfate 0.8 MG / ferrous fumarate 130 MG / folate 1 MG / magnesium sulfate 6.9 MG / manganese sulfate 1.3 MG / vit-B3 20 MG / polysaccharide iron complex 92.4 MG / vit-B6 hydrochloride 25 MG / riboflavin 5 MG / vit-B1 mononitrate 5 MG / vitamin B12 0.01 MG / ZnSO4 18.2 MG Oral Capsule"},{"tty":"SCD","name":"2 ML magnesium sulfate 500 MG/ML Injection","rxcui":"1658221","synonym":"magnesium sulfate 1 GM per 2 ML Injection"},{"tty":"SCD","name":"20 ML magnesium sulfate 500 MG/ML Injection","rxcui":"1658236","synonym":"magnesium sulfate 10 GM per 20 ML Injection"},{"tty":"SCD","name":"10 ML magnesium sulfate 500 MG/ML Injection","rxcui":"1658244","synonym":"magnesium sulfate 5 GM per 10 ML Injection"},{"tty":"SCD","name":"50 ML magnesium sulfate 500 MG/ML Injection","rxcui":"1658245","synonym":"magnesium sulfate 25 GM per 50 ML Injection"},{"tty":"SCD","name":"50 ML magnesium sulfate 40 MG/ML Injection","rxcui":"1658259","synonym":"magnesium sulfate 2 GM per 50 ML Injection"},{"tty":"SCD","name":"100 ML magnesium sulfate 40 MG/ML Injection","rxcui":"1658262","synonym":"magnesium sulfate 4 GM per 100 ML Injection"},{"tty":"SCD","name":"500 ML magnesium sulfate 40 MG/ML Injection","rxcui":"1658264","synonym":"magnesium sulfate 20 GM per 500 ML Injection"},{"tty":"SCD","name":"1000 ML magnesium sulfate 40 MG/ML Injection","rxcui":"1658265","synonym":"magnesium sulfate 40 GM per 1000 ML Injection"},{"tty":"SCD","name":"magnesium sulfate 100 MG Oral Capsule","rxcui":"1666549","synonym":""},{"tty":"SCD","name":"magnesium sulfate 0.4 MG/MG Topical Ointment","rxcui":"1945074","synonym":"magnesium sulfate 40 % Topical Ointment"},{"tty":"SCD","name":"magnesium sulfate 225 MG / potassium chloride 188 MG / sodium sulfate 1479 MG Oral Tablet","rxcui":"2465554","synonym":"magnesium sulfate 225 MG / K+ chloride 188 MG / sodium sulfate 1479 MG Oral Tablet"},{"tty":"SCD","name":"magnesium sulfate 900 MG / polyethylene glycol 3350 179000 MG / potassium chloride 1120 MG / sodium chloride 500 MG / sodium sulfate 7300 MG Powder for Oral Solution","rxcui":"2641142","synonym":"magnesium sulfate 900 MG / polyethylene glycol 3350 179000 MG / K+ chloride 1120 MG / NaCl 500 MG / sodium sulfate 7300 MG Powder for Oral Solution"},{"tty":"SCD","name":"100 ML magnesium sulfate 30 MG/ML Injection","rxcui":"2731632","synonym":"magnesium sulfate 3 GM per 100 ML Injection"},{"tty":"SCD","name":"magnesium sulfate 0.2 MG/ML / monobasic potassium phosphate 0.063 MG/ML / potassium chloride 0.005 MEQ/ML / sodium chloride 0.14 MEQ/ML / sodium phosphate dihydrate 0.088 MG/ML Irrigation Solution","rxcui":"801442","synonym":"Magnesium Sulfate 0.2 MG/ML / Monobasic K+ phosphate 0.063 MG/ML / K+ Chloride 0.005 MEQ/ML / NaCl 0.14 MEQ/ML / SODIUM PHOSPHATE DIHYDRATE 0.088 MG/ML Irrigation Solution"},{"tty":"SCD","name":"copper sulfate 0.8 MG / ferrous fumarate 324 MG / folic acid 1 MG / magnesium sulfate 6.9 MG / manganese sulfate 1.3 MG / niacinamide 30 MG / pantothenic acid 10 MG / pyridoxine 5 MG / riboflavin 6 MG / sodium ascorbate 200 MG / thiamine 10 MG / vitamin B12 0.015 MG / zinc sulfate 18.2 MG Oral Capsule","rxcui":"802693","synonym":"copper sulfate 0.8 MG / ferrous fumarate 324 MG / folate 1 MG / magnesium sulfate 6.9 MG / manganese sulfate 1.3 MG / niacinamide 30 MG / pantothenic acid 10 MG / vit-B6 5 MG / riboflavin 6 MG / sodium ascorbate 200 MG / vit-B1 10 MG / vitamin B12 0.015 MG / ZnSO4 18.2 MG Oral Capsule"},{"tty":"SCD","name":"50 ML magnesium sulfate 80 MG/ML Injection","rxcui":"829734","synonym":"magnesium sulfate 4 GM per 50 ML Injection"},{"tty":"SCD","name":"100 ML magnesium sulfate 10 MG/ML Injection","rxcui":"829757","synonym":"magnesium sulfate 1 GM per 100 ML Injection"},{"tty":"SCD","name":"10 ML magnesium sulfate 500 MG/ML Prefilled Syringe","rxcui":"829762","synonym":"magnesium sulfate 5 GM per 10 ML Prefilled Syringe"}],"storageAndHandling":"Storage Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.","participantFlowData":[],"faersSexDistribution":[{"term":2,"count":11520},{"term":1,"count":6414},{"term":0,"count":56}],"genericManufacturers":12,"_genericFilersChecked":true,"nonclinicalToxicology":"13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility.\n13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Studies with Magnesium Sulfate in 5% Dextrose Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility.","structuredTrialResults":[],"genericManufacturerList":["Amneal","Aspiro","B Braun Medical","Baxter Hlthcare Corp","Exela Pharma","Fresenius Kabi Usa","Gland","Hospira","Hq Spclt Pharma","Milla Pharms","Mylan Labs Ltd","Pharmobedient"],"faersSeriousnessBreakdown":[{"term":1,"count":12558},{"term":2,"count":6632}],"genericFilers":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"companionDiagnostics":[],"trials":[],"biosimilars":[],"offLabel":[],"developmentCodes":[],"aliases":[],"status":"approved","companyName":"Hospira","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"1981","enrichmentLevel":5,"visitCount":17,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":52,"withResults":3},"validation":{"fieldsValidated":5,"lastValidatedAt":"2026-04-20T08:24:57.806814+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}