{"id":"magnesium-sulfate-heptahydrate","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Depressed reflexes"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression (at high doses)"},{"rate":null,"effect":"Diarrhea (oral formulation)"}]},"_chembl":null,"_dailymed":{"setId":"6a5d362b-7aa7-40d3-898d-09407cce0713","title":"MAGNESIUM SULFATE (MAGNESIUM SULFATE HEPTAHYDRATE) INJECTION, SOLUTION [FRESENIUS KABI USA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium ions compete with calcium for entry into cells and block NMDA-type glutamate receptors, thereby reducing excitatory neurotransmission. This mechanism underlies its use in preventing seizures (particularly eclampsia/pre-eclampsia), treating cardiac arrhythmias, and providing bronchodilation in acute asthma. The heptahydrate form is the standard pharmaceutical salt used for parenteral and oral administration.","oneSentence":"Magnesium sulfate acts as a physiological calcium antagonist and NMDA receptor antagonist, reducing neuronal excitability and smooth muscle contractility.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:51:15.701Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure prophylaxis in pre-eclampsia and eclampsia"},{"name":"Acute asthma exacerbation (IV bronchodilator)"},{"name":"Cardiac arrhythmias (torsades de pointes)"},{"name":"Magnesium deficiency / hypomagnesemia"},{"name":"Constipation (oral laxative)"}]},"trialDetails":[{"nctId":"NCT07191652","phase":"","title":"The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index","status":"RECRUITING","sponsor":"Istanbul University - 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