{"id":"magnesium-sulfate-33-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing and warmth sensation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression (at high doses)"},{"rate":null,"effect":"Hypermagnesemia"},{"rate":null,"effect":"Loss of deep tendon reflexes"}]},"_chembl":{"chemblId":"CHEMBL3989857","moleculeType":"Small molecule","molecularWeight":"246.47"},"_fixedAt":"2026-03-30T17:12:30.534925","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium ions compete with calcium for binding sites on voltage-gated calcium channels and block NMDA-type glutamate receptors, thereby decreasing cellular excitability. This mechanism underlies its use in preventing seizures (particularly eclampsia/pre-eclampsia), treating cardiac arrhythmias, and providing bronchodilation in acute asthma. The 33% solution provides a concentrated form for parenteral administration.","oneSentence":"Magnesium sulfate acts as a physiological calcium antagonist and NMDA receptor antagonist, reducing neuronal excitability and smooth muscle contractility.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:45.036Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure prophylaxis and treatment in pre-eclampsia and eclampsia"},{"name":"Acute asthma exacerbation (bronchodilation)"},{"name":"Cardiac arrhythmias (particularly torsades de pointes)"},{"name":"Magnesium deficiency (hypomagnesemia)"},{"name":"Constipation (as laxative)"}]},"_fixedFields":["pubmed(1)"],"trialDetails":[{"nctId":"NCT04464005","phase":"PHASE4","title":"Comparison Between Pads With Cold Solution of Magnesium Sulfate or Cold Water Postpartum Perineal Pain and Healing","status":"UNKNOWN","sponsor":"The Baruch Padeh Medical Center, Poriya","startDate":"2023-11-15","conditions":"Women After Delivery With Perineal Pain","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"recentPublications":[{"date":"1997 Nov-Dec","pmid":"9589929","title":"[The clinical significance of phasic duodenal intubation and ultrasonic monitoring of the gallbladder in healthy subjects].","journal":"Likars'ka sprava"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Magnesium sulfate 33% solution","genericName":"Magnesium sulfate 33% solution","companyName":"The Baruch Padeh Medical Center, Poriya","companyId":"the-baruch-padeh-medical-center-poriya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium sulfate acts as a physiological calcium antagonist and NMDA receptor antagonist, reducing neuromuscular excitability and vascular smooth muscle contractility. Used for Seizure prophylaxis in preeclampsia and eclampsia, Preterm labor management, Hypertensive emergency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}