{"id":"magnesium-sulfate-12-hours","safety":{"commonSideEffects":[{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Sweating"},{"rate":null,"effect":"Hyporeflexia"},{"rate":null,"effect":"Muscle weakness"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium sulfate works through multiple mechanisms: it blocks NMDA receptors to reduce neuronal excitability, acts as a natural calcium antagonist to inhibit acetylcholine release at the neuromuscular junction, and stabilizes cell membranes. The 12-hour dosing regimen suggests use in obstetrics for seizure prophylaxis in preeclampsia/eclampsia, where sustained magnesium levels are maintained to prevent convulsions.","oneSentence":"Magnesium sulfate acts as a central nervous system depressant and anticonvulsant by blocking N-methyl-D-aspartate (NMDA) receptors and reducing neuromuscular transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:47.783Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Seizure prophylaxis in preeclampsia and eclampsia"},{"name":"Hypomagnesemia treatment"},{"name":"Tocolysis in preterm labor"}]},"trialDetails":[{"nctId":"NCT07478055","phase":"PHASE4","title":"Biomarkers in Management of Post Partum Preeclampsia","status":"NOT_YET_RECRUITING","sponsor":"Alexander Harrison","startDate":"2026-03-31","conditions":"Preeclampsia Severe, Preeclampsia Postpartum","enrollment":100},{"nctId":"NCT07248332","phase":"PHASE1","title":"The Efface of Lidocaine 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Makinde","startDate":"2020-11-04","conditions":"Acute Post-operative Pain Following Caesarean Section","enrollment":324},{"nctId":"NCT04599868","phase":"PHASE2","title":"High Versus Low Dose of Magnesium Sulfate as Initial Tocolytic Agent for Preterm Labour in Symptomatic Placenta Previa.","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-12-01","conditions":"Placenta Previa Bleeding","enrollment":130},{"nctId":"NCT04223219","phase":"PHASE4","title":"Different Modalities of Analgesia in Open Heart Surgeries in Mansoura University","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2019-12-10","conditions":"Coronary Artery Disease, Valve Disease, Heart, Pain, Acute","enrollment":90},{"nctId":"NCT03204344","phase":"NA","title":"Preoperative Oral Carbohydrate and Postoperative Recovery in Diabetic Patients","status":"COMPLETED","sponsor":"Dong-Xin Wang","startDate":"2017-08-01","conditions":"Gastrointestinal 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Sciences","startDate":"2020-12-01","conditions":"Stroke, Ischemic Stroke","enrollment":44},{"nctId":"NCT00042367","phase":"NA","title":"Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2000-04-04","conditions":"Brain Tumors","enrollment":119},{"nctId":"NCT01911494","phase":"NA","title":"Community Level Interventions for Pre-eclampsia","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2013-09","conditions":"Pre-eclampsia, Hypertension, Pregnancy Induced","enrollment":87500},{"nctId":"NCT01083537","phase":"PHASE1, PHASE2","title":"Trial of Best Supportive Care and Either Cisplatin or Paclitaxel to Treat Patients With Primary Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer and Inoperable Malignant Bowel Obstruction","status":"TERMINATED","sponsor":"University Health Network, Toronto","startDate":"2010-02","conditions":"Ovarian 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Bronchiolitis","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2012-10","conditions":"Bronchiolitis, Magnesium, Abnormal Blood Level","enrollment":200},{"nctId":"NCT01846156","phase":"PHASE3","title":"New Magnesium Sulphate Protocol for Pre-eclampsia","status":"COMPLETED","sponsor":"Cairo University","startDate":"2013-05","conditions":"Pre-eclampsia","enrollment":240},{"nctId":"NCT01408979","phase":"PHASE4","title":"Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia","status":"COMPLETED","sponsor":"Instituto Materno Infantil Prof. Fernando Figueira","startDate":"2011-08","conditions":"Severe 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Used for Seizure prophylaxis and treatment in preeclampsia and eclampsia, Acute seizure management in pregnancy, Hypomagnesemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}