{"id":"magnesium-pantoprazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Hypomagnesemia (with long-term use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pantoprazole is a proton pump inhibitor (PPI) that irreversibly binds to and blocks the H+/K+-ATPase enzyme in the gastric mucosa, preventing the final step of gastric acid production. The magnesium salt formulation improves bioavailability and gastrointestinal tolerability compared to standard pantoprazole formulations. This mechanism provides sustained acid suppression for the treatment of acid-related gastrointestinal disorders.","oneSentence":"Magnesium pantoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:03.168Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Acid-related gastrointestinal disorders"}]},"trialDetails":[{"nctId":"NCT07076914","phase":"PHASE2","title":"Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy","status":"NOT_YET_RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2025-10-02","conditions":"Primary Lung Cancer, Non Small Cell Lung Cancer, Small Cell Lung Cancer","enrollment":58},{"nctId":"NCT04221165","phase":"PHASE2","title":"Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2020-08-04","conditions":"Head and Neck Cancer, Radiation-Induced Mucositis","enrollment":49},{"nctId":"NCT00978016","phase":"PHASE2","title":"A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)","status":"COMPLETED","sponsor":"XenoPort, Inc.","startDate":"2009-09","conditions":"Gastroesophageal Reflux Disease","enrollment":460},{"nctId":"NCT02637557","phase":"PHASE2","title":"A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)","status":"COMPLETED","sponsor":"Ironwood Pharmaceuticals, Inc.","startDate":"2016-03-01","conditions":"Gastroesophageal Reflux Disease","enrollment":282},{"nctId":"NCT01281501","phase":"PHASE4","title":"Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2011-01","conditions":"Dyspepsia, Emergency, Pain","enrollment":87},{"nctId":"NCT01499693","phase":"PHASE3","title":"Magnesium Pantoprazole 20mg b.i.d. vs Magnesium Pantoprazole 40mg q.d. on Intragastric Acid Inhibition","status":"WITHDRAWN","sponsor":"Takeda","startDate":"","conditions":"Gastric pH Control","enrollment":""},{"nctId":"NCT01132638","phase":"PHASE3","title":"Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Disease","status":"COMPLETED","sponsor":"Takeda","startDate":"2011-08","conditions":"GERD","enrollment":713},{"nctId":"NCT00247715","phase":"NA","title":"Comparison of a \"Step-Up\" Versus a \"Step-Down\" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)","status":"COMPLETED","sponsor":"Radboud University Medical Center","startDate":"2003-10","conditions":"Dyspepsia, Gastrointestinal Diseases","enrollment":664}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":43,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Magnesium Pantoprazole","genericName":"Magnesium Pantoprazole","companyName":"Takeda","companyId":"takeda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium pantoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Acid-related gastrointestinal disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}