{"id":"magnesium-oxide","rwe":[{"pmid":"41886148","year":"2026","title":"Modifying alkali-activated materials with reactive MgO: A comprehensive overview of mechanisms and performance.","finding":"","journal":"Environmental science and pollution research international","studyType":"Clinical Study"},{"pmid":"41850154","year":"2026","title":"Exposure to magnesium oxide nanoparticles induces mitochondrial dysfunction and apoptosis in fish Megalobrama amblycephala by disrupting magnesium homeostasis.","finding":"","journal":"Aquatic toxicology (Amsterdam, Netherlands)","studyType":"Clinical Study"},{"pmid":"41844722","year":"2026","title":"Sustainable synthesis of MgO nanoparticles from Persea americana for cultivar dependent nanostructure, environmental remediation and bioactivity supported by molecular docking.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41836722","year":"2026","title":"Magnesium Oxide Nanoparticles Loaded with 6-Gingerol: A Bioinspired Approach to Anticancer, Anti-Inflammatory, and Antioxidant Therapy.","finding":"","journal":"International journal of nanomedicine","studyType":"Clinical Study"},{"pmid":"41829346","year":"2026","title":"Tailoring Flame Retardance and Thermal Conductivity of Epoxy/Benzoxazine Mixtures via Aluminum Trihydrate and Ceramic Hybridization.","finding":"","journal":"Polymers","studyType":"Clinical Study"}],"_fda":{"id":"41b54dc8-16af-7ea0-e063-6394a90ad7b2","set_id":"0af63651-f9d9-43b9-b6f0-4878466a82e6","openfda":{"unii":["3A3U0GI71G"],"route":["ORAL"],"rxcui":["198741"],"spl_id":["41b54dc8-16af-7ea0-e063-6394a90ad7b2"],"brand_name":["Magnesium Oxide"],"spl_set_id":["0af63651-f9d9-43b9-b6f0-4878466a82e6"],"package_ndc":["58657-120-12"],"product_ndc":["58657-120"],"generic_name":["MAGNESIUM OXIDE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["MAGNESIUM OXIDE"],"manufacturer_name":["Method Pharmaceuticals, LLC"],"application_number":["M001"],"is_original_packager":[true]},"purpose":["Purpose Antacid"],"version":"7","warnings":["Warnings Ask a doctor before use if you have kidney disease you are taking a prescription drug (antacids may interact with certain prescription drugs) you are pregnant or breast feeding. Do not take more than 2 tablets in a 24 hour period. May have a laxative effect. Keep out of reach of children."],"questions":["Questions? Call Method at 1-877-250-3427 or FDA at 1-800-FDA-1088 Manufactured for: Method Pharmaceuticals, LLC Fort Worth, Texas 76118 Rev. 04/18"],"ask_doctor":["Ask a doctor before use if you have kidney disease you are taking a prescription drug (antacids may interact with certain prescription drugs) you are pregnant or breast feeding. Do not take more than 2 tablets in a 24 hour period. May have a laxative effect."],"effective_time":"20251021","active_ingredient":["Active ingredient Magnesium Oxide 400 mg (241.3 mg Elemental Magnesium)"],"inactive_ingredient":["Inactive ingredients Croscarmellose Sodium, Microcrystalline Cellulose, Silicon Dioxide, and Stearic Acid."],"storage_and_handling":["Other information Store at controlled room temperature 15° to 30°C (59° to 86°F). Tamper evident, do not use if imprinted safety seal under cap is broken or missing."],"indications_and_usage":["Use relieves: ■ acid indigestion ■ upset stomach"],"spl_unclassified_section":["Drug Facts"],"dosage_and_administration":["Directions take one or two antacid tablets daily. Do not exceed two tablets unless directed by a physician."],"spl_product_data_elements":["Magnesium Oxide Magnesium Oxide CROSCARMELLOSE SODIUM CELLULOSE, MICROCRYSTALLINE SILICON DIOXIDE STEARIC ACID MAGNESIUM OXIDE MAGNESIUM CATION 120"],"keep_out_of_reach_of_children":["Keep out of reach of children."],"package_label_principal_display_panel":["Principal Display Panel NDC 58657-120-12 Magnesium Oxide 400 mg 241.3 Elemental Magnesium Antacid 120 Tablets label"]},"tags":[{"label":"magnesium oxide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A02AA02","category":"atc"},{"label":"TOPICAL","category":"route"},{"label":"ORAL","category":"route"},{"label":"oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Liquid","category":"form"},{"label":"Pill","category":"form"},{"label":"Powder","category":"form"},{"label":"Active","category":"status"},{"label":"Constipation","category":"indication"},{"label":"Hypocalcemia","category":"indication"},{"label":"Hypomagnesemia","category":"indication"},{"label":"Incomplete passage of stool","category":"indication"},{"label":"Indigestion","category":"indication"},{"label":"Osteoporosis","category":"indication"},{"label":"Baxter Hlthcare","category":"company"},{"label":"Approved 1980s","category":"decade"},{"label":"Antacids","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"2907 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"2644 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"2447 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"2072 reports"},{"date":"","signal":"PNEUMONIA","source":"FDA FAERS","actionTaken":"2038 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"1962 reports"},{"date":"","signal":"PYREXIA","source":"FDA FAERS","actionTaken":"1834 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"1760 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"1646 reports"},{"date":"","signal":"DEATH","source":"FDA FAERS","actionTaken":"1611 reports"}],"drugInteractions":[{"url":"/drug/minocycline","drug":"minocycline","action":"Monitor closely","effect":"May interact with Minocycline","source":"DrugCentral","drugSlug":"minocycline"},{"url":"/drug/tetracycline","drug":"tetracycline","action":"Monitor closely","effect":"May interact with Tetracycline","source":"DrugCentral","drugSlug":"tetracycline"},{"url":"/drug/zalcitabine","drug":"zalcitabine","action":"Monitor closely","effect":"MAGNESIUM OXIDE/ZALCITABINE (DIDEOXYCYTIDINE,ddC)","source":"DrugCentral","drugSlug":"zalcitabine"}],"commonSideEffects":[{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"common","organSystem":""},{"effect":"Abdominal pain","drugRate":"","severity":"common","organSystem":""},{"effect":"Diarrhea","drugRate":"","severity":"common","organSystem":""},{"effect":"Abdominal bloating","drugRate":"","severity":"common","organSystem":""},{"effect":"Abdominal distention","drugRate":"","severity":"common","organSystem":""},{"effect":"Abdominal cramping","drugRate":"","severity":"common","organSystem":""},{"effect":"Watery diarrhea","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Arteriosclerosis obliterans","Bipolar disorder","Blood coagulation disorder","Carcinoma of female breast","Chronic heart failure","Conduction disorder of the heart","Dehydration","Diarrhea","Disease of liver","Endometrial carcinoma","Esophageal Compression","Esophageal dysmotility","Gastrointestinal hemorrhage","Gastrointestinal obstruction","Gastroparesis","Genitourinary Tract Infections","Hypercalcemia","Hypercalciuria","Hyperkalemia","Hyperparathyroidism","Hyperphosphatemia","Hypervitaminosis D","Hypocupremia","Hypomania","Impaired renal function disorder"],"specialPopulations":{"Lactation":"There are no data on the presence of magnesium oxide or anhydrous citric acid in either human or animal milk, the effects on the breastfed infant, or the effects on milk production. Published data on lactating women indicate that the active metabolite of sodium picosulfate, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) remained below the limit of detection (1 ng/mL) in breast milk after both single and multiple doses of 10 mg/day.","Pregnancy":"There are no data with CLENPIQ use in pregnant women to determine drug-associated risk of adverse developmental outcomes. In animal reproduction studies, no adverse developmental effects were observed in pregnant rats when sodium picosulfate, magnesium oxide, and anhydrous citric acid were administered orally at doses 1.2 times the recommended human dose based on body surface area during organogenesis.","Geriatric use":"Clinical studies on this product have not been performed in subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious and start at the lower end of the dosing range.","Paediatric use":"Safety and effectiveness in pediatric patients have not been established."},"seriousAdverseEvents":[{"effect":"Rash","drugRate":"","severity":"serious"},{"effect":"Urticaria","drugRate":"","severity":"serious"},{"effect":"Purpura","drugRate":"","severity":"serious"},{"effect":"Hypoglycemia","drugRate":"","severity":"serious"},{"effect":"Electrolyte abnormalities","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Baxter","patents":[{"source":"FDA Orange Book via DrugCentral","expires":"2034-06-26","territory":"US","patentNumber":"9827231"},{"source":"FDA Orange Book via DrugCentral","expires":"2034-06-23","territory":"US","patentNumber":"10624879"},{"source":"FDA Orange Book via DrugCentral","expires":"2034-06-23","territory":"US","patentNumber":"11191753"},{"source":"FDA Orange Book via DrugCentral","expires":"2028-10-10","territory":"US","patentNumber":"8450338"},{"source":"FDA Orange Book via DrugCentral","expires":"2028-10-10","territory":"US","patentNumber":"8481083"}],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$0.0329/EA","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$12","description":"MAGNESIUM OXIDE 400 MG TABLET","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MAGNESIUM OXIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:07:19.749916+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-20T00:07:14.669936+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Magnesium Oxide","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T00:07:27.548882+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:07:25.575647+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:07:13.424863+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MAGNESIUM OXIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:07:25.872861+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA 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(EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:07:27.197318+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M001","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:07:12.509522+00:00"}},"allNames":"prepopik","offLabel":[],"synonyms":["magnesium oxide"],"timeline":[{"date":"1982-06-22","type":"positive","source":"DrugCentral","milestone":"FDA approval (Baxter Hlthcare)"}],"brandName":"Prepopik","ecosystem":[{"indication":"Constipation","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic acid","slug":"cholic-acid","company":"Rtrx"},{"name":"docusate sodium","slug":"docusate-sodium","company":""},{"name":"glycerol","slug":"glycerol","company":"B Braun"}],"globalPrevalence":null},{"indication":"Hypocalcemia","otherDrugs":[{"name":"calcifediol","slug":"calcifediol","company":""},{"name":"calcitriol","slug":"calcitriol","company":"Validus Pharms"},{"name":"calcium acetate","slug":"calcium-acetate","company":"B Braun"},{"name":"calcium carbonate","slug":"calcium-carbonate","company":"Mcneil Cons"}],"globalPrevalence":null},{"indication":"Hypomagnesemia","otherDrugs":[{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"},{"name":"magnesium chloride","slug":"magnesium-chloride","company":"Hospira"},{"name":"magnesium sulfate","slug":"magnesium-sulfate","company":"Baxter Hlthcare"}],"globalPrevalence":null},{"indication":"Incomplete passage of stool","otherDrugs":[{"name":"bisacodyl","slug":"bisacodyl","company":"Braintree"},{"name":"cholic 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acid","slug":"alendronic-acid","company":"Merck And Co Inc"},{"name":"bazedoxifene","slug":"bazedoxifene","company":"Wyeth Pharms Pfizer"},{"name":"calcitonin (salmon synthetic)","slug":"calcitonin-(salmon-synthetic)","company":"Sanofi Aventis Us"},{"name":"calcium citrate","slug":"calcium-citrate","company":""}],"globalPrevalence":200000000}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"magnesium oxide","explanation":"","oneSentence":"","technicalDetail":"Prepopik (Magnesium Oxide) acts as a magnesium supplement, increasing the concentration of magnesium ions in the body. Magnesium plays a crucial role in muscle relaxation and contraction, and its deficiency can lead to muscle cramps, spasms, and impaired bowel function. By replenishing magnesium levels, Prepopik helps to alleviate symptoms of constipation, hypocalcemia, and osteoporosis."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Sodium_picosulfate","title":"Sodium picosulfate","extract":"Sodium picosulfate is a contact stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery.","wiki_society_and_culture":"== Society and culture ==\n=== Brand names ===\nIt is sold under the brand names Sodipic Picofast, Laxoberal, Laxoberon, Purg-Odan, Picolax, Guttalax, Namilax, Pico-Salax, PicoPrep, and Prepopik,"},"commercial":{"launchDate":"1982","_launchSource":"DrugCentral (FDA 1982-06-22, BAXTER HLTHCARE)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4293","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MAGNESIUM%20OXIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MAGNESIUM OXIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Sodium_picosulfate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T02:37:06.077008","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T00:07:35.195828+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"magnesium carbonate","drugSlug":"magnesium-carbonate","fdaApproval":"1990-10-02","relationship":"same-class"},{"drugName":"magnesium hydroxide","drugSlug":"magnesium-hydroxide","fdaApproval":"2000-10-16","relationship":"same-class"},{"drugName":"magnesium silicate","drugSlug":"magnesium-silicate","fdaApproval":"1983-12-09","relationship":"same-class"}],"dataSources":[{"url":"https://data.medicaid.gov/dataset/4j6z-xnwq","name":"CMS National Average Drug Acquisition Cost (NADAC)","fields":["pricing"],"retrievedDate":"2026-04-07"}],"genericName":"magnesium oxide","indications":{"approved":[{"id":"magnesium-oxide-acid-indigestion-relief","name":"Acid Indigestion Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":"Prepopik"},{"id":"magnesium-oxide-upset-stomach-relief","name":"Upset Stomach Relief","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":"Prepopik"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"magnesium-carbonate","brandName":"magnesium carbonate","genericName":"magnesium carbonate","approvalYear":"1990","relationship":"same-class"},{"drugId":"magnesium-hydroxide","brandName":"magnesium hydroxide","genericName":"magnesium hydroxide","approvalYear":"2000","relationship":"same-class"},{"drugId":"magnesium-silicate","brandName":"magnesium silicate","genericName":"magnesium silicate","approvalYear":"1983","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01073930","phase":"PHASE3","title":"Investigation of PicoPrep Versus HalfLytely for Bowel Preparation for Colonoscopy - Split Dose PicoPrep","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","isPivotal":true,"startDate":"2010-05","conditions":["Bowel Preparation"],"enrollment":608,"completionDate":"2010-10"},{"nctId":"NCT03017235","phase":"PHASE3","title":"A Study Comparing the Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid Oral Solution With PREPOPIK® for Colon Cleansing in Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","isPivotal":true,"startDate":"2017-02-20","conditions":["Bowel Preparation"],"enrollment":917,"completionDate":"2017-10-12"},{"nctId":"NCT01928862","phase":"PHASE1,PHASE2","title":"Efficacy and Safety of Prepopik® in Children for Overall Colon Cleansing in Preparation for Colonoscopy","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","isPivotal":true,"startDate":"2014-06-03","conditions":["Need for Bowel Preparation"],"enrollment":78,"completionDate":"2017-03-16"},{"nctId":"NCT04930237","phase":"","title":"RELISTOR's Effects on Opioid-Induced Constipation","status":"WITHDRAWN","sponsor":"Methodist Health System","startDate":"2021-07-01","conditions":["OIC"],"enrollment":0,"completionDate":"2022-04-22"},{"nctId":"NCT07475299","phase":"NA","title":"Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2026-04","conditions":["Irritable Bowel Syndrome (IBS)"],"enrollment":8,"completionDate":"2027-01"},{"nctId":"NCT06335797","phase":"NA","title":"Optimization of Postoperative Bowel Habits","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2024-10-16","conditions":["Constipation"],"enrollment":88,"completionDate":"2027-05"},{"nctId":"NCT06915701","phase":"PHASE2,PHASE3","title":"\"Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis\"","status":"RECRUITING","sponsor":"University of Guadalajara","startDate":"2026-02-06","conditions":["Rheumatoid Arthritis"],"enrollment":46,"completionDate":"2027-01-15"},{"nctId":"NCT05488847","phase":"PHASE4","title":"Opioid-Free Pain Protocol After Shoulder Arthroplasty","status":"ACTIVE_NOT_RECRUITING","sponsor":"Henry Ford Health System","startDate":"2022-06-25","conditions":["Shoulder Arthropathy","Shoulder Pain"],"enrollment":83,"completionDate":"2026-09-01"},{"nctId":"NCT07389837","phase":"NA","title":"Maple Syrup Carbohydrate Dose-Response on 20-km Cycling Time-Trial Performance","status":"NOT_YET_RECRUITING","sponsor":"Université de Montréal","startDate":"2026-02-01","conditions":["Exercise","Endurance Cycling Performance","Carbohydrate Intolerance","Sport Nutrition"],"enrollment":32,"completionDate":"2027-06-01"},{"nctId":"NCT04341571","phase":"PHASE2","title":"Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Guadalajara","startDate":"2019-10-24","conditions":["PreDiabetes","Impaired Glucose Tolerance","Hyperglycemia","Resistance, Insulin"],"enrollment":30,"completionDate":"2026-12"},{"nctId":"NCT04113382","phase":"PHASE1,PHASE2","title":"Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy","status":"RECRUITING","sponsor":"Ferring Pharmaceuticals","startDate":"2022-06-23","conditions":["Bowel Preparation"],"enrollment":30,"completionDate":"2026-03"},{"nctId":"NCT06994585","phase":"NA","title":"Comparing the Bowel Cleansing Efcacy of Picosulfate Sodium/ Citric Acid / Magnesium Oxide and Polyethylene Glycol: A Randomized Trial in Taiwan","status":"COMPLETED","sponsor":"Fu Jen Catholic University Hospital","startDate":"2024-03-20","conditions":["Bowel Preparation"],"enrollment":440,"completionDate":"2025-01-21"},{"nctId":"NCT07173855","phase":"PHASE4","title":"Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients","status":"RECRUITING","sponsor":"Scarborough General Hospital","startDate":"2025-11-25","conditions":["Critical Illness"],"enrollment":3253,"completionDate":"2027-06-01"},{"nctId":"NCT07265115","phase":"NA","title":"Preventive Nutritional Supplements for Preclinical Pathologies","status":"COMPLETED","sponsor":"Centro de Edafología y Biología Aplicada del Segura","startDate":"2025-06-02","conditions":["Prediabetes"],"enrollment":21,"completionDate":"2025-10-07"},{"nctId":"NCT05774015","phase":"NA","title":"Effect of Oral Magnesium Supplementation on Type II Diabetes Mellitus Guided by Serum Ionized Magnesium Level","status":"COMPLETED","sponsor":"Sultan Qaboos University","startDate":"2023-09-25","conditions":["Type 2 Diabetes","Magnesium Disorder"],"enrollment":247,"completionDate":"2025-09-11"},{"nctId":"NCT06543290","phase":"PHASE1","title":"Azithromycin Before Induction","status":"RECRUITING","sponsor":"Arrowhead Regional Medical 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