{"id":"magnesium-orotate","rwe":[{"pmid":"40642284","year":"2025","title":"Safety of magnesium orotate dihydrate as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of magnesium from this source in the context of Directive 2002/46/EC.","finding":"","journal":"EFSA journal. European Food Safety Authority","studyType":"Clinical Study"},{"pmid":"39242786","year":"2024","title":"Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"37373177","year":"2023","title":"Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"36214550","year":"2022","title":"Corrigendum to \"biopharmaceutics classification and pharmacokinetics study of magnesium orotate\" (Mag Res 2019;32:132-42).","finding":"","journal":"Magnesium research","studyType":"Clinical Study"},{"pmid":"35955803","year":"2022","title":"Effects of Combining Biofactors on Bioenergetic Parameters, Aβ Levels and Survival in Alzheimer Model Organisms.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"}],"tags":[{"label":"magnesium orotate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12CC09","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["magnesium orotate"],"offLabel":[],"synonyms":["magnesium orotate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"magnesium orotate","explanation":"Think of free radicals like rogue molecules that can damage cells and contribute to aging and disease. Magnesium orotate helps to neutralize these free radicals by donating electrons, which can help to protect cells and reduce inflammation. This can lead to a range of potential benefits, including improved energy levels and reduced oxidative stress.","oneSentence":"Magnesium orotate works by donating electrons to neutralize free radicals and reducing oxidative stress in the body.","technicalDetail":"Magnesium orotate is thought to exert its effects through its ability to chelate and donate electrons, thereby reducing oxidative stress and inflammation. This may be mediated through its interaction with various cellular pathways, including those involved in antioxidant defense and mitochondrial function."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Magnesium_orotate","title":"Magnesium orotate","extract":"Magnesium orotate, the magnesium salt of orotic acid, is a mineral supplement. It can be used in treating extracellular magnesium deficiency, as well as in mitigating magnesium depletion that inhibits the binding of adenosine triphosphate via orotic acid, which provides binding sites."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4594","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=magnesium%20orotate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=magnesium orotate","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Magnesium_orotate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:12:55.180200","biosimilars":[],"competitors":[{"drugName":"magnesium chloride","drugSlug":"magnesium-chloride","fdaApproval":"1975-08-13","relationship":"same-class"},{"drugName":"magnesium sulfate","drugSlug":"magnesium-sulfate","fdaApproval":"1981-10-06","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"magnesium citrate","drugSlug":"magnesium-citrate","fdaApproval":"","relationship":"same-class"},{"drugName":"magnesium oxide","drugSlug":"magnesium-oxide","fdaApproval":"1982-06-22","relationship":"same-class"}],"genericName":"magnesium orotate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"magnesium-chloride","brandName":"magnesium chloride","genericName":"magnesium chloride","approvalYear":"1975","relationship":"same-class"},{"drugId":"magnesium-sulfate","brandName":"magnesium sulfate","genericName":"magnesium sulfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"magnesium-citrate","brandName":"magnesium citrate","genericName":"magnesium citrate","approvalYear":"","relationship":"same-class"},{"drugId":"magnesium-oxide","brandName":"magnesium oxide","genericName":"magnesium oxide","approvalYear":"1982","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06152991","phase":"PHASE3","title":"Clinical Trial Assessing Godex Carnitine Orotate Complex in Nonalcoholic Fatty Liver Disease Patients for Efficacy","status":"ENROLLING_BY_INVITATION","sponsor":"Yoon Jun Kim","startDate":"2023-09-25","conditions":["Non-Alcoholic Fatty Liver Disease"],"enrollment":196,"completionDate":"2027-02-26"},{"nctId":"NCT00906646","phase":"PHASE3","title":"Preparation of Patients for Cardiac Surgery","status":"COMPLETED","sponsor":"Bayside Health","startDate":"2004-04","conditions":["Coronary Artery Bypass Graft Surgery","Cardiac Valve Surgery"],"enrollment":117,"completionDate":"2008-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003854","UNII":"GI96W46M5A","RXNORM":"139233","UMLSCUI":"C0536004","ChEMBL_ID":"CHEMBL3707282","DRUGBANK_ID":"DB13786","PUBCHEM_CID":"3036905","SNOMEDCT_US":"419831006","MESH_SUPPLEMENTAL_RECORD_UI":"C104468"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":59,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A12CC09","allCodes":["A12CC09"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Jul","pmid":"40642284","title":"Safety of magnesium orotate dihydrate as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of magnesium from this source in the context of Directive 2002/46/EC.","journal":"EFSA journal. European Food Safety Authority"},{"date":"2024 Sep 6","pmid":"39242786","title":"Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.","journal":"Scientific reports"},{"date":"2023 Jun 12","pmid":"37373177","title":"Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease.","journal":"International journal of molecular sciences"},{"date":"2022 Jan 1","pmid":"36214550","title":"Corrigendum to \"biopharmaceutics classification and pharmacokinetics study of magnesium orotate\" (Mag Res 2019;32:132-42).","journal":"Magnesium research"},{"date":"2022 Aug 4","pmid":"35955803","title":"Effects of Combining Biofactors on Bioenergetic Parameters, Aβ Levels and Survival in Alzheimer Model Organisms.","journal":"International journal of molecular sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"magnesium orotate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Magnesium orotate is a small molecule drug belonging to the magnesium orotate class. It is a derivative of orotic acid, a naturally occurring compound found in the body. The exact target and mechanism of action of magnesium orotate are not well established, but it is thought to have antioxidant and anti-inflammatory properties. Magnesium orotate is not FDA-approved for any specific indication, and its commercial status is unclear. As a result, there is limited information available on its safety profile and potential side effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}