{"id":"magnesium-chloride","rwe":[],"_fda":{"id":"38f81b8c-e9ff-2e12-e063-6394a90aac6f","set_id":"0956bd7c-d46f-483a-bf2c-9e11c6111ebf","openfda":{"unii":["02F3473H9O","TU7HW0W0QT","LX22YL083G","451W47IQ8X","M4I0D6VV5M"],"route":["INTRAPERITONEAL"],"rxcui":["800111","800115","800472","800474"],"spl_id":["38f81b8c-e9ff-2e12-e063-6394a90aac6f"],"brand_name":["DIANEAL LOW CALCIUM WITH DEXTROSE"],"spl_set_id":["0956bd7c-d46f-483a-bf2c-9e11c6111ebf"],"package_ndc":["0941-0733-01","0941-0733-04","0941-0735-01","0941-0735-04"],"product_ndc":["0941-0733","0941-0735"],"generic_name":["SODIUM CHLORIDE, SODIUM LACTATE, CALCIUM CHLORIDE, MAGNESIUM CHLORIDE AND DEXTROSE"],"product_type":["HUMAN PRESCRIPTION DRUG"],"substance_name":["CALCIUM CHLORIDE","DEXTROSE MONOHYDRATE","MAGNESIUM CHLORIDE","SODIUM CHLORIDE","SODIUM LACTATE"],"manufacturer_name":["Vantive US Healthcare LLC"],"is_original_packager":[true]},"version":"6","effective_time":"20250702","spl_product_data_elements":["DIANEAL LOW CALCIUM WITH DEXTROSE sodium chloride, sodium lactate, calcium chloride, magnesium chloride and dextrose DEXTROSE MONOHYDRATE ANHYDROUS DEXTROSE SODIUM CHLORIDE SODIUM CATION CHLORIDE ION SODIUM LACTATE SODIUM CATION LACTIC ACID, UNSPECIFIED FORM CALCIUM CHLORIDE CALCIUM CATION CHLORIDE ION MAGNESIUM CHLORIDE MAGNESIUM CATION CHLORIDE ION DIANEAL LOW CALCIUM WITH DEXTROSE sodium chloride, sodium lactate, calcium chloride, magnesium chloride and dextrose DEXTROSE MONOHYDRATE ANHYDROUS DEXTROSE SODIUM CHLORIDE SODIUM CATION CHLORIDE ION SODIUM LACTATE SODIUM CATION LACTIC ACID, UNSPECIFIED FORM CALCIUM CHLORIDE CALCIUM CATION CHLORIDE ION MAGNESIUM CHLORIDE MAGNESIUM CATION CHLORIDE ION"],"health_care_provider_letter":["Health Care Provider Letter Dianeal DHCP Letter 1 Dianeal DHCP Letter 2 Dianeal DHCP Letter 3 Dianeal DHCP Letter 4 Dianeal DHCP Letter 5 Dianeal DHCP Letter 6 Dianeal DHCP Letter 7 Dianeal DHCP Letter 8 Dianeal DHCP Letter 9 Dianeal DHCP Letter 10"],"package_label_principal_display_panel":["PACKAGE/LABEL PRINCIPAL DISPLAY PANEL Lot Exp Baxter Logo FPB9718R 2500 ml DIANEAL PD4 Glucose 1,36% w/v / 13,6 mg/ml Solution for Peritoneal Dialysis Formula g/l Osmolarity 344 mOsmol/l Anhydrous Glucose C 6 H 12 O 6 13,6 g mmol/l Sodium Chloride NaCl 5,38 g Na + 132 Sodium Lactate C 3 H 5 NaO 3 4,48 g Ca ++ 1,25 Calcium Chloride CaCl 2 ·2H 2 O 0,184 g Mg ++ 0,25 Magnesium Chloride MgCl 2 ·6H 2 O 0,051 g Cl - 95 Water for Injections to 1000 ml C 3 H 5 O 3 - 40 Free from Bacterial Endotoxins For Intraperitoneal infusion Not for intravenous infusion Do not use unless the solution is clear and the container undamaged For single use only Once removed from the overpouch use immediately Discard unused solution Do not store above 25°C Do not refrigerate or freeze Keep out of the sight and reach of children UK: Baxter Healthcare Ltd Caxton Way Thetford Norfolk IP24 3SE UK IE and MT: Baxter Holding B.V ., Kobaltweg 49, 3542CE, Utrecht, Netherlands POM Symbol PA 2299/015/001 PL 00116/0230 MA 1277/01001 CB-35-04-620 FPB9718R 2500 ml x 4 Dianeal PD4 Glucose 1.36% w/v / 13,6 mg/ml Solution for Peritoneal Dialysis Formula g/l Anhydrous Glucose 13,6 g Sodium Chloride 5,38 g Sodium Lactate 4,48 g Calcium Chloride 0,184 g Magnesium Chloride 0,051 g Water for Injections to 1000 ml Free from bacterial endotoxins. For intraperitoneal infusion. Not for intravenous use. For single use only. Do not use unless the solution is clear and the container undamaged. Once removed from the overpouch use immediately. Discard unused solution. Keep out of the sight and reach of children. UK: Baxter Healthcare Limited Caxton Way, Thetford, Norfolk, IP24 3SE United Kingdom IE and MT: Baxter Holding B.V. Kobaltweg 49, 3542CE Utrecht, Netherlands PA 2299/015/001 PL 00116/0230 MA 1277/01001 POM Symbol Lot: Single bag with Luer connector Do not store above 25°C. Do not refrigerate or freeze. 88-46-13-208 Barcode (01)50085412574429(17)201200(10)88B88B88B8 Dianeal PD4 Glucose FPB9718R 1.36% w/v / 13,6 mg/ml 2500 ml x 4 Lot: Lot Exp Vantive Logo FPB9718R 2500 ml DIANEAL PD4 Glucose 1,36% w/v / 13,6 mg/ml Solution for Peritoneal Dialysis Formula g/l Osmolarity 344 mOsmol/l Anhydrous Glucose C 6 H 12 O 6 13,6 g mmol/l Sodium Chloride NaCl 5,38 g Na + 132 Sodium Lactate C 3 H 5 NaO 3 4,48 g Ca ++ 1,25 Calcium Chloride CaCl 2 ·2H 2 O 0,184 g Mg ++ 0,25 Magnesium Chloride MgCl 2 ·6H 2 O 0,051 g Cl - 95 Water for Injections to 1000 ml C 3 H 5 O 3 - 40 Free from Bacterial Endotoxins For Intraperitoneal infusion Not for intravenous infusion Do not use unless the solution is clear and the container undamaged For single use only Once removed from the overpouch use immediately Discard unused solution Do not store above 25°C Do not refrigerate or freeze Keep out of the sight and reach of children Vantive Limited Wavertree Technology Park 2 Wavertree Boulevard Liverpool, L7 9PE United Kingdom POM Symbol PL 58711/0002 CB-35-05-245 FPB9718R 2500 ml x 4 Dianeal PD4 Glucose 1.36% w/v / 13,6 mg/ml Solution for Peritoneal Dialysis Formula g/l Anhydrous Glucose 13,6 g Sodium Chloride 5,38 g Sodium Lactate 4,48 g Calcium Chloride 0,184 g Magnesium Chloride 0,051 g Water for Injections to 1000 ml Free from bacterial endotoxins. For intraperitoneal infusion. Not for intravenous use. For single use only. Do not use unless the solution is clear and the container undamaged. Once removed from the overpouch use immediately. Discard unused solution. Keep out of the sight and reach of children. Vantive Limited Wavertree Technology Park 2 Wavertree Boulevard Liverpool, L7 9PE United Kingdom PL 58711/0002 POM Symbol Lot: UK Only Single bag with Luer connector Do not store above 25°C. Do not refrigerate or freeze. 88-46-13-978 Barcode (01)57332414203561(17)201200(10)88B88B88B8 Dianeal PD4 Glucose FPB9718R 1.36% w/v / 13,6 mg/ml 2500 ml x 4 Lot: Lot Exp Baxter Logo FPB9728R 2500 ml DIANEAL PD4 Glucose 2,27% w/v / 22,7 mg/ml Solution for Peritoneal Dialysis Formula g/l Osmolarity 395 mOsmol/l Anhydrous Glucose C 6 H 12 O 6 22,7 g mmol/l Sodium Chloride NaCl 5,38 g Na + 132 Sodium Lactate C 3 H 5 NaO 3 4,48 g Ca ++ 1,25 Calcium Chloride CaCl 2 ·2H 2 O 0,184 g Mg ++ 0,25 Magnesium Chloride MgCl 2 ·6H 2 O 0,051 g Cl - 95 Water for Injections to 1000 ml C 3 H 5 O 3 - 40 Free from Bacterial Endotoxins For Intraperitoneal infusion Not for intravenous infusion Do not use unless the solution is clear and the container undamaged For single use only Once removed from the overpouch use immediately Discard unused solution Do not store above 25°C Do not refrigerate or freeze Keep out of the sight and reach of children UK: Baxter Healthcare Ltd Caxton Way Thetford Norfolk IP24 3SE UK IE and MT: Baxter Holding B.V . Kobaltweg 49 3542CE Utrecht, Netherlands POM Symbol PA 2299/015/002 PL 00116/0231 MA 1277/01002 CB-35-04-621 FPB9728R 2500 ml x 4 Dianeal PD4 Glucose 2.27% w/v / 22,7 mg/ml Solution for Peritoneal Dialysis Formula g/l Anhydrous Glucose 22,7 g Sodium Chloride 5,38 g Sodium Lactate 4,48 g Calcium Chloride 0,184 g Magnesium Chloride 0,051 g Water for Injections to 1000 ml Free from bacterial endotoxins. For intraperitoneal infusion. Not for intravenous use. For single use only. Do not use unless the solution is clear and the container undamaged. Once removed from the overpouch use immediately. Discard unused solution. Keep out of the sight and reach of children. UK: Baxter Healthcare Limited Caxton Way, Thetford, Norfolk, IP24 3SE United Kingdom IE and MT: Baxter Holding B.V. Kobaltweg 49, 3542CE Utrecht, Netherlands PA 2299/015/002 PL 00116/0231 MA 1277/01002 POM Symbol Lot: Single bag with Luer connector Do not store above 25°C. Do not refrigerate or freeze. 88-46-13-209 Barcode (01)50085412574436(17)201200(10)88B88B88B8 Dianeal PD4 Glucose FPB9728R 2.27% w/v / 22,7 mg/ml 2500 ml x 4 Lot: Lot Exp Vantive Logo FPB9728R 2500 ml DIANEAL PD4 Glucose 2,27% w/v / 22,7 mg/ml Solution for Peritoneal Dialysis Formula g/l Osmolarity 395 mOsmol/l Anhydrous Glucose C 6 H 12 O 6 22,7 g mmol/l Sodium Chloride NaCl 5,38 g Na + 132 Sodium Lactate C 3 H 5 NaO 3 4,48 g Ca ++ 1,25 Calcium Chloride CaCl 2 ·2H 2 O 0,184 g Mg ++ 0,25 Magnesium Chloride MgCl 2 ·6H 2 O 0,051 g Cl - 95 Water for Injections to 1000 ml C 3 H 5 O 3 - 40 Free from Bacterial Endotoxins For Intraperitoneal infusion Not for intravenous infusion Do not use unless the solution is clear and the container undamaged For single use only Once removed from the overpouch use immediately Discard unused solution Do not store above 25°C Do not refrigerate or freeze Keep out of the sight and reach of children Vantive Limited Wavertree Technology Park 2 Wavertree Boulevard Liverpool, L7 9PE United Kingdom POM Symbol PL 58711/0003 CB-35-05-246 FPB9728R 2500 ml x 4 Dianeal PD4 Glucose 2.27% w/v / 22,7 mg/ml Solution for Peritoneal Dialysis Formula g/l Anhydrous Glucose 22,7 g Sodium Chloride 5,38 g Sodium Lactate 4,48 g Calcium Chloride 0,184 g Magnesium Chloride 0,051 g Water for Injections to 1000 ml Free from bacterial endotoxins. For intraperitoneal infusion. Not for intravenous use. For single use only. Do not use unless the solution is clear and the container undamaged. Once removed from the overpouch use immediately. Discard unused solution. Keep out of the sight and reach of children. Vantive Limited Wavertree Technology Park 2 Wavertree Boulevard Liverpool, L7 9PE United Kingdom PL 58711/0003 POM Symbol Lot: UK Only Single bag with Luer connector Do not store above 25°C. Do not refrigerate or freeze. 88-46-13-979 Barcode (01)5733241420885(17)201200(10)88B88B88B8 Dianeal PD4 Glucose FPB9728R 2.27% w/v / 22,7 mg/ml 2500 ml x 4 Lot: Dianeal Representative Container Label Dianeal Representative Carton Label Dianeal Representative Container Label Dianeal Representative Carton Label Dianeal Representative Container Label Dianeal Representative Carton Label Dianeal Representative Container Label Dianeal Representative Carton Label"],"package_label_principal_display_panel_table":["
Formulag/lOsmolarity344mOsmol/l
Anhydrous GlucoseC 6H 12O 613,6 gmmol/l
Sodium ChlorideNaCl5,38 gNa +132
Sodium LactateC 3H 5NaO 34,48 gCa ++1,25
Calcium ChlorideCaCl 2·2H 2O 0,184 gMg ++0,25
Magnesium ChlorideMgCl 2·6H 2O 0,051 gCl -95
Water for Injections to 1000ml C 3H 5O 3-40
","
Formulag/l
Anhydrous Glucose13,6 g
Sodium Chloride5,38 g
Sodium Lactate4,48 g
Calcium Chloride0,184 g
Magnesium Chloride0,051 g
Water for Injections to 1000 ml
","
Formulag/lOsmolarity344mOsmol/l
Anhydrous GlucoseC 6H 12O 613,6 gmmol/l
Sodium ChlorideNaCl5,38 gNa +132
Sodium LactateC 3H 5NaO 34,48 gCa ++1,25
Calcium ChlorideCaCl 2·2H 2O 0,184 gMg ++0,25
Magnesium ChlorideMgCl 2·6H 2O 0,051 gCl -95
Water for Injections to 1000ml C 3H 5O 3-40
","
Formulag/l
Anhydrous Glucose13,6 g
Sodium Chloride5,38 g
Sodium Lactate4,48 g
Calcium Chloride0,184 g
Magnesium Chloride0,051 g
Water for Injections to 1000 ml
","
Formulag/lOsmolarity395mOsmol/l
Anhydrous GlucoseC 6H 12O 622,7 gmmol/l
Sodium ChlorideNaCl5,38 gNa +132
Sodium LactateC 3H 5NaO 34,48 gCa ++1,25
Calcium ChlorideCaCl 2·2H 2O 0,184 gMg ++0,25
Magnesium ChlorideMgCl 2·6H 2O 0,051 gCl -95
Water for Injections to 1000ml C 3H 5O 3-40
","
Formulag/l
Anhydrous Glucose22,7 g
Sodium Chloride5,38 g
Sodium Lactate4,48 g
Calcium Chloride0,184 g
Magnesium Chloride0,051 g
Water for Injections to 1000 ml
","
Formulag/lOsmolarity395mOsmol/l
Anhydrous GlucoseC 6H 12O 622,7 gmmol/l
Sodium ChlorideNaCl5,38 gNa +132
Sodium LactateC 3H 5NaO 34,48 gCa ++1,25
Calcium ChlorideCaCl 2·2H 2O 0,184 gMg ++0,25
Magnesium ChlorideMgCl 2·6H 2O 0,051 gCl -95
Water for Injections to 1000ml C 3H 5O 3-40
","
Formulag/l
Anhydrous Glucose22,7 g
Sodium Chloride5,38 g
Sodium Lactate4,48 g
Calcium Chloride0,184 g
Magnesium Chloride0,051 g
Water for Injections to 1000 ml
"]},"tags":[{"label":"magnesium chloride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A12CC01","category":"atc"},{"label":"Intraperitoneal","category":"route"},{"label":"Intravenous","category":"route"},{"label":"Intra-Arterial","category":"route"},{"label":"Injection","category":"form"},{"label":"Active","category":"status"},{"label":"Hypomagnesemia","category":"indication"},{"label":"Hospira","category":"company"},{"label":"Approved 1970s","category":"decade"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DEATH","source":"FDA FAERS","actionTaken":"7614 reports"},{"date":"","signal":"PERITONITIS","source":"FDA FAERS","actionTaken":"3801 reports"},{"date":"","signal":"PERITONITIS BACTERIAL","source":"FDA FAERS","actionTaken":"2490 reports"},{"date":"","signal":"PERITONEAL DIALYSIS COMPLICATION","source":"FDA FAERS","actionTaken":"1736 reports"},{"date":"","signal":"HYPOTENSION","source":"FDA FAERS","actionTaken":"1632 reports"},{"date":"","signal":"MYOCARDIAL INFARCTION","source":"FDA FAERS","actionTaken":"1513 reports"},{"date":"","signal":"PNEUMONIA","source":"FDA FAERS","actionTaken":"1398 reports"},{"date":"","signal":"INFECTION","source":"FDA FAERS","actionTaken":"1383 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"1237 reports"},{"date":"","signal":"SEPSIS","source":"FDA FAERS","actionTaken":"1225 reports"}],"commonSideEffects":[],"contraindications":["Acute nephropathy","Anuria","Azotemia","Classical phenylketonuria","Complete atrioventricular block","Congenital myotonia, autosomal dominant form","Diarrhea","End stage renal disease","Familial hyperkalemic periodic paralysis","Heart disease","Humoral hypercalcemia of malignancy","Hypercalcemia","Hypercalciuria","Hyperchloremia","Hyperkalemia","Hypermagnesemia","Hypocalcemia","Hyporeninemic hypoaldosteronism","Kidney disease","Kidney stone","Oliguria","Poisoning by digitalis glycoside","Sarcoidosis","Severe dehydration","Third degree burn injury"],"specialPopulations":{"Pregnancy":"Magnesium Chloride should be given to pregnant woman only if clearly needed."}},"trials":[],"aliases":[],"company":"Pfizer","patents":[{"source":"FDA Orange Book via DrugCentral","expires":"2023-03-04","territory":"US","patentNumber":"7300674"}],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MAGNESIUM CHLORIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:45:01.042545+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-20T00:45:01.042461+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:45:06.351231+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:45:00.079659+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MAGNESIUM CHLORIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:45:06.671778+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:44:53.626548+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:44:53.626579+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:45:08.744731+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3185229/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:45:07.891128+00:00"}},"allNames":"plegisol in plastic container","offLabel":[],"synonyms":["magnesium chloride"],"timeline":[{"date":"1975-08-13","type":"positive","source":"DrugCentral","milestone":"FDA approval (Hospira)"}],"aiSummary":"Plegisol In Plastic Container is a small molecule medication. It is also known by synonyms such as BISCHOFITE, BISCHOFITE (MGCL2.6H2O), E-511, INS-511, INS NO.511, and MAGNESIA MURIATICA.","approvals":[{"date":"1975-08-13","orphan":false,"company":"HOSPIRA","regulator":"FDA"}],"brandName":"Plegisol In Plastic Container","ecosystem":[{"indication":"Hypomagnesemia","otherDrugs":[{"name":"magnesium carbonate","slug":"magnesium-carbonate","company":"United Guardian"},{"name":"magnesium oxide","slug":"magnesium-oxide","company":"Baxter Hlthcare"},{"name":"magnesium sulfate","slug":"magnesium-sulfate","company":"Baxter Hlthcare"}],"globalPrevalence":null}],"mechanism":{"novelty":"First-in-class","modality":"Small Molecule","drugClass":"magnesium chloride","explanation":"","oneSentence":"","technicalDetail":"Magnesium chloride acts as a magnesium supplement, increasing serum magnesium concentrations to treat hypomagnesemia. It is absorbed through the gastrointestinal tract and distributed throughout the body, where it plays a crucial role in neuronal and muscular function."},"commercial":{"launchDate":"1975","_launchSource":"DrugCentral (FDA 1975-08-13, HOSPIRA)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4200","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MAGNESIUM%20CHLORIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MAGNESIUM CHLORIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:05:23.776810","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:45:09.660906+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"magnesium sulfate","drugSlug":"magnesium-sulfate","fdaApproval":"1981-10-06","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"magnesium citrate","drugSlug":"magnesium-citrate","fdaApproval":"","relationship":"same-class"},{"drugName":"magnesium oxide","drugSlug":"magnesium-oxide","fdaApproval":"1982-06-22","relationship":"same-class"}],"genericName":"magnesium chloride","indications":{"approved":[{"name":"Hypomagnesemia","source":"DrugCentral","snomedId":190855004,"regulator":"FDA","eligibility":"patients with magnesium deficiencies"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"magnesium-sulfate","brandName":"magnesium sulfate","genericName":"magnesium sulfate","approvalYear":"1981","relationship":"same-class"},{"drugId":"magnesium-citrate","brandName":"magnesium citrate","genericName":"magnesium 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