{"id":"magic-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Local numbness or altered taste"},{"rate":null,"effect":"Mild gastrointestinal upset if swallowed"},{"rate":null,"effect":"Allergic reaction to components"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:11:39.114046","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magic Mouthwash typically contains a combination of ingredients such as viscous lidocaine (local anesthetic), diphenhydramine (antihistamine), and magnesium aluminum hydroxide (antacid) or nystatin (antifungal), depending on formulation. These agents work synergistically to numb pain, reduce inflammation, coat damaged mucous membranes, and prevent secondary infections in patients experiencing chemotherapy- or radiation-induced oral mucositis.","oneSentence":"Magic Mouthwash is a topical oral rinse that combines local anesthetics, antimicrobials, and anti-inflammatory agents to relieve oral mucositis pain and promote healing in cancer patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:01.148Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced oral mucositis"},{"name":"Radiation-induced oral mucositis"},{"name":"Cancer treatment-related oral pain and inflammation"}]},"_fixedFields":["pubmed(28)"],"trialDetails":[{"nctId":"NCT06819033","phase":"PHASE4","title":"Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-03-10","conditions":"Aphthous Ulcer","enrollment":30},{"nctId":"NCT06660017","phase":"PHASE2","title":"Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse","status":"NOT_YET_RECRUITING","sponsor":"University of Oklahoma","startDate":"2024-11","conditions":"Head and Neck Cancer","enrollment":62},{"nctId":"NCT05369234","phase":"PHASE3","title":"Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis","status":"COMPLETED","sponsor":"Covenant Health Cancer Center","startDate":"2022-01-20","conditions":"Oral Cavity Cancer, Head and Neck Cancers - Tonsils, Esophageal Cancer","enrollment":100},{"nctId":"NCT01668849","phase":"PHASE1","title":"Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2012-08-02","conditions":"Head and Neck Cancer, Oral Mucositis","enrollment":60},{"nctId":"NCT02480114","phase":"PHASE3","title":"Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy","status":"COMPLETED","sponsor":"Vanderbilt-Ingram Cancer Center","startDate":"2015-07","conditions":"Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder","enrollment":79},{"nctId":"NCT03490396","phase":"PHASE4","title":"Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients","status":"TERMINATED","sponsor":"Midatech Pharma US Inc.","startDate":"2018-05-15","conditions":"Oral Mucositis","enrollment":28},{"nctId":"NCT02606994","phase":"PHASE2","title":"Effect of Over-the-counter Toothpastes on Chemotherapy-induced Oral Mucositis","status":"TERMINATED","sponsor":"Oral Defense, LLC","startDate":"2018-05-29","conditions":"Mucositis, Neoplasms","enrollment":1},{"nctId":"NCT01837446","phase":"PHASE2, PHASE3","title":"Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2011-07","conditions":"Stomatitis","enrollment":30},{"nctId":"NCT00814359","phase":"PHASE3","title":"Magic Mouthwash Plus Sucralfate Versus Benzydamine Hydrochloride for the Treatment of Radiation-induced Mucositis","status":"COMPLETED","sponsor":"Juravinski Cancer Centre Foundation","startDate":"2009-05","conditions":"Head and Neck Cancer, Mucositis","enrollment":67}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"recentPublications":[{"date":"2025 Aug","pmid":"40821416","title":"Chemical Stability of Diphenhydramine in \"Magic Mouthwash\" Stored at Room and Refrigerated Temperatures for 90-Days.","journal":"The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG"},{"date":"2025 Jun 21","pmid":"40544276","title":"The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial.","journal":"BMC oral health"},{"date":"2025 Jun 2","pmid":"40223546","title":"Beware of the rinse: magic mouthwash as a rare cause of iatrogenic Cushing syndrome and secondary adrenal insufficiency.","journal":"The Medical journal of Australia"},{"date":"2024 Dec 9","pmid":"39543079","title":"Beware of the rinse: magic mouthwash as a rare cause of iatrogenic Cushing syndrome and secondary adrenal insufficiency.","journal":"The Medical journal of Australia"},{"date":"2025 Feb","pmid":"39177466","title":"Effective Treatment of Methotrexate Induced Oral Mucositis With a Morphine Mouthwash Solution: A Case Report.","journal":"Journal of pharmacy practice"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Miracle Mouthwash","First-Mouthwash BLM","First-BXN Mouthwash"],"phase":"phase_3","status":"active","brandName":"Magic Mouthwash","genericName":"Magic Mouthwash","companyName":"Vanderbilt-Ingram Cancer Center","companyId":"vanderbilt-ingram-cancer-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magic Mouthwash is used to treat conditions such as mucositis, neoplasms, head and neck cancer, oral mucositis, and oral cavity cancer. It is typically compared to other interventions like Crest Toothpaste and Oral Defense Toothpaste in clinical trials for its effectiveness in healing chemotherapy-induced oral mucositis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}