{"id":"maduramicin","rwe":[{"pmid":"41734486","year":"2026","title":"A qualitative screening method for 17 coccidiostats in eggs and animal muscle by QuEChERS-UPLC-MS/MS validated according to Regulation (EU) 2021/808.","finding":"","journal":"Journal of chromatography. A","studyType":"Clinical Study"},{"pmid":"41422187","year":"2025","title":"Target gene mutation discovery and amplicon sequencing for evaluating maduramicin resistance in Eimeria tenella.","finding":"","journal":"Communications biology","studyType":"Clinical Study"},{"pmid":"41385912","year":"2026","title":"Molecular characterization and analysis of enoyl-CoA hydratase/isomerase family protein of Eimeria tenella.","finding":"","journal":"European journal of protistology","studyType":"Clinical Study"},{"pmid":"41355480","year":"2026","title":"Molecular Characterization of Superoxide Dismutase and Its Putative Relationship With Drug Resistance in Eimeria Tenella.","finding":"","journal":"The Journal of eukaryotic microbiology","studyType":"Clinical Study"},{"pmid":"41004933","year":"2025","title":"Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella.","finding":"","journal":"International journal for parasitology. Drugs and drug resistance","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"5-hydroxytryptamine receptor 6","category":"target"},{"label":"HTR6","category":"gene"},{"label":"HTR2A","category":"gene"},{"label":"DRD3","category":"gene"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cygro","offLabel":[],"synonyms":["maduramicin","maduramicin ammonium","maduramycin ammonium","CL-273703","cygro"],"timeline":[],"aiSummary":"Cygro, also known as Maduramicin, is a small molecule modality targeting the 5-hydroxytryptamine receptor 6. Its exact drug class is unknown, and it has not been approved by the FDA for any indications. As a result, there is limited information available on its commercial status, pharmacokinetics, or safety profile. Further research is needed to fully understand the properties and potential applications of Cygro. Its development history is also unclear, with no information available on its original developer or current owner.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Cygro","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B","novelty":"First-in-class","targets":[{"gene":"HTR6","source":"DrugCentral","target":"5-hydroxytryptamine receptor 6","protein":"5-hydroxytryptamine receptor 6"},{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"}],"modality":"Small Molecule","explanation":"Imagine your brain has many different locks, and serotonin is the key that fits into some of those locks. Cygro is a special key that fits into one of those locks, called the 5-hydroxytryptamine receptor 6. By binding to this lock, Cygro can affect how your brain cells communicate with each other.","oneSentence":"Cygro works by binding to the 5-hydroxytryptamine receptor 6, a subtype of serotonin receptor.","technicalDetail":"Cygro acts as a selective agonist at the 5-hydroxytryptamine receptor 6, modulating serotonin-mediated signaling pathways in the brain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5571","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MADURAMICIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:27:50.244242","biosimilars":[],"competitors":[{"drugName":"acepromazine","drugSlug":"acepromazine","fdaApproval":"","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"amitriptyline","drugSlug":"amitriptyline","fdaApproval":"1961-04-07","genericCount":33,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amoxapine","drugSlug":"amoxapine","fdaApproval":"1980-09-22","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"apomorphine","drugSlug":"apomorphine","fdaApproval":"2004-04-20","patentExpiry":"Jun 11, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"brexpiprazole","drugSlug":"brexpiprazole","fdaApproval":"2015-07-10","patentExpiry":"Oct 12, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"bromocriptine","drugSlug":"bromocriptine","fdaApproval":"1978-06-28","patentExpiry":"Jun 7, 2030","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"maduramicin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acepromazine","brandName":"acepromazine","genericName":"acepromazine","approvalYear":"","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"amitriptyline","brandName":"amitriptyline","genericName":"amitriptyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"amoxapine","brandName":"amoxapine","genericName":"amoxapine","approvalYear":"1980","relationship":"same-target"},{"drugId":"apomorphine","brandName":"apomorphine","genericName":"apomorphine","approvalYear":"2004","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"brexpiprazole","brandName":"brexpiprazole","genericName":"brexpiprazole","approvalYear":"2015","relationship":"same-target"},{"drugId":"bromocriptine","brandName":"bromocriptine","genericName":"bromocriptine","approvalYear":"1978","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"5U912U22T2","INN_ID":"5670","UMLSCUI":"C0065503","ChEMBL_ID":"CHEMBL1909065","KEGG_DRUG":"","DRUGBANK_ID":"DB11525","PUBCHEM_CID":"68595","SNOMEDCT_US":"96159004","MESH_SUPPLEMENTAL_RECORD_UI":"C018091"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":174,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Apr 12","pmid":"41734486","title":"A qualitative screening method for 17 coccidiostats in eggs and animal muscle by QuEChERS-UPLC-MS/MS validated according to Regulation (EU) 2021/808.","journal":"Journal of chromatography. A"},{"date":"2025 Dec 20","pmid":"41422187","title":"Target gene mutation discovery and amplicon sequencing for evaluating maduramicin resistance in Eimeria tenella.","journal":"Communications biology"},{"date":"2026 Feb","pmid":"41385912","title":"Molecular characterization and analysis of enoyl-CoA hydratase/isomerase family protein of Eimeria tenella.","journal":"European journal of protistology"},{"date":"2026 Jan-Feb","pmid":"41355480","title":"Molecular Characterization of Superoxide Dismutase and Its Putative Relationship With Drug Resistance in Eimeria Tenella.","journal":"The Journal of eukaryotic microbiology"},{"date":"2025 Dec","pmid":"41004933","title":"Ribosomal protein L27 contributes to virulence and maduramicin resistance in Eimeria tenella.","journal":"International journal for parasitology. 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