{"id":"macrogol-forlax","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal bloating"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Flatulence"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Macrogol (polyethylene glycol) is a non-absorbable polymer that creates an osmotic gradient in the colon, increasing water retention in the intestinal lumen. This softens fecal matter and increases stool bulk, stimulating peristalsis and facilitating evacuation. It is not systemically absorbed and acts locally within the gastrointestinal tract.","oneSentence":"Macrogol is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:43.761Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation (functional and occasional)"},{"name":"Bowel preparation prior to colonoscopy or other gastrointestinal procedures"}]},"trialDetails":[{"nctId":"NCT06357897","phase":"NA","title":"The Efficacy and Palatability of Developed Polyethylene Glycol-based Formula for Children With Functional Constipation","status":"RECRUITING","sponsor":"Chulalongkorn University","startDate":"2024-05-03","conditions":"Functional Constipation","enrollment":52},{"nctId":"NCT01875744","phase":"PHASE4","title":"Polyethylene Glycol for Childhood Constipation","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2013-06","conditions":"Constipation","enrollment":90},{"nctId":"NCT00255372","phase":"PHASE3","title":"To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.","status":"COMPLETED","sponsor":"Ipsen","startDate":"2005-04","conditions":"Chronic Constipation","enrollment":88},{"nctId":"NCT00276354","phase":"PHASE4","title":"Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation","status":"COMPLETED","sponsor":"Ipsen","startDate":"1999-12","conditions":"Constipation","enrollment":246},{"nctId":"NCT02102373","phase":"NA","title":"Evaluation of Two Different Diet Regimen Prior to Colonoscopy in Children","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2014-03","conditions":"Children Prior to Colonoscopy","enrollment":184},{"nctId":"NCT02526849","phase":"PHASE2","title":"Efficacy and Safety of Fecal Microbiota Transplantation for Slow Transit Constipation","status":"UNKNOWN","sponsor":"Jinling Hospital, China","startDate":"2015-11","conditions":"Slow Transit Constipation","enrollment":100},{"nctId":"NCT01810653","phase":"PHASE4","title":"A Study to Compare the Effect of Transipeg 2.95 g or Forlax Junior 4 g in Children With Constipation","status":"COMPLETED","sponsor":"Bayer","startDate":"2006-04","conditions":"Constipation","enrollment":97},{"nctId":"NCT02292459","phase":"PHASE3","title":"Efficacy and Safety of Polyethylene Glycol 3350 (PEG 3350) for Relief of Constipation (MK-8114-005)","status":"WITHDRAWN","sponsor":"Bayer","startDate":"2015-12","conditions":"Constipation","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"CYTOLYTIC HEPATITIS"}],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Macrogol (Forlax)","genericName":"Macrogol (Forlax)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Macrogol is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements. Used for Constipation, Bowel preparation before colonoscopy or other gastrointestinal procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}