{"id":"maalox-plus-benadryl","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Maalox (aluminum hydroxide and magnesium hydroxide) neutralizes gastric acid through direct chemical reaction, while Benadryl (diphenhydramine) is an H1 receptor antagonist that reduces histamine-mediated acid secretion and provides anticholinergic effects to decrease gastric motility. This combination approach addresses both existing acid and the mechanisms driving acid production.","oneSentence":"This combination antacid and antihistamine reduces stomach acid while blocking histamine-mediated gastric secretion and providing anticholinergic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:26.224Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heartburn and acid indigestion"},{"name":"Peptic ulcer disease"}]},"trialDetails":[{"nctId":"NCT06819033","phase":"PHASE4","title":"Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-03-10","conditions":"Aphthous Ulcer","enrollment":30},{"nctId":"NCT03490396","phase":"PHASE4","title":"Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients","status":"TERMINATED","sponsor":"Midatech Pharma US Inc.","startDate":"2018-05-15","conditions":"Oral Mucositis","enrollment":28},{"nctId":"NCT02300727","phase":"PHASE1, PHASE2","title":"Study to See How Safe Curcumin is and How Well it Works When Used to Treat Mucositis in Patients Getting Chemotherapy","status":"TERMINATED","sponsor":"Amy Beres","startDate":"2015-02","conditions":"Mucositis","enrollment":6},{"nctId":"NCT02606994","phase":"PHASE2","title":"Effect of Over-the-counter Toothpastes on Chemotherapy-induced Oral Mucositis","status":"TERMINATED","sponsor":"Oral Defense, LLC","startDate":"2018-05-29","conditions":"Mucositis, Neoplasms","enrollment":1},{"nctId":"NCT01837446","phase":"PHASE2, PHASE3","title":"Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2011-07","conditions":"Stomatitis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Maalox plus Benadryl","genericName":"Maalox plus Benadryl","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination antacid and antihistamine reduces stomach acid while blocking histamine-mediated gastric secretion and providing anticholinergic effects. Used for Heartburn and acid indigestion, Peptic ulcer disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}