{"id":"m518101","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"M518101 is an investigational compound in phase 3 development by Maruho Co., Ltd., a Japanese pharmaceutical company specializing in dermatology. Without disclosed mechanism details, the drug's exact molecular target and therapeutic pathway remain proprietary. Given Maruho's focus on dermatological treatments, M518101 is likely formulated for topical application to treat skin disorders.","oneSentence":"M518101 is a topical agent developed for dermatological use, likely targeting inflammatory or proliferative skin conditions.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:19:58.188Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT01989429","phase":"PHASE3","title":"Efficacy Study Comparing Topical M518101 and Vitamin D3 in Adult Psoriasis Patients","status":"COMPLETED","sponsor":"Maruho Europe Limited","startDate":"2013-10","conditions":"Plaque Psoriasis","enrollment":788},{"nctId":"NCT01301157","phase":"PHASE2","title":"Study to Investigate the Efficacy and the Safety of M518101 in Plaque Psoriasis Patients","status":"COMPLETED","sponsor":"Maruho Co., Ltd.","startDate":"2011-02","conditions":"Plaque Psoriasis","enrollment":294},{"nctId":"NCT01878461","phase":"PHASE3","title":"Evaluate the Efficacy and Safety of M518101 in Subjects With Plaque Psoriasis","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2013-06","conditions":"Psoriasis","enrollment":542},{"nctId":"NCT01873677","phase":"PHASE3","title":"Study to Evaluate the Efficacy and Safety of M518101 in Subjects With Plaque Psoriasis","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2013-06","conditions":"Psoriasis","enrollment":537},{"nctId":"NCT01908595","phase":"PHASE3","title":"Long Term Study to Evaluate Safety and Efficacy of M518101 in Subjects With Plaque Psoriasis","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2013-08","conditions":"Psoriasis","enrollment":480},{"nctId":"NCT02256930","phase":"PHASE1","title":"Skin Safety Study to Evaluate the Sensitizing Potential in Healthy Volunteers","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2014-09","conditions":"Healthy Volunteers","enrollment":240},{"nctId":"NCT02227069","phase":"PHASE1","title":"Skin Safety Study to Evaluate the Irritation Potential in Healthy Volunteers","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2014-09","conditions":"Healthy Volunteers","enrollment":30},{"nctId":"NCT01844973","phase":"PHASE1","title":"Study to Evaluate the Pharmacokinetics and the Safety of M518101 in Plaque Psoriasis Patients","status":"COMPLETED","sponsor":"Maruho North America Inc.","startDate":"2013-04","conditions":"Psoriasis","enrollment":30},{"nctId":"NCT00884169","phase":"PHASE2","title":"Study to Investigate the Efficacy and the Safety of M518101 in Psoriasis Patients","status":"COMPLETED","sponsor":"Maruho Co., Ltd.","startDate":"2009-07","conditions":"Plaque Psoriasis","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["vitamin D3","psoriasis treatment"],"phase":"phase_3","status":"active","brandName":"M518101","genericName":"M518101","companyName":"Maruho Co., Ltd.","companyId":"maruho-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}