{"id":"lyrica-pregabalin","safety":{"commonSideEffects":[{"rate":"20–30%","effect":"Dizziness"},{"rate":"15–25%","effect":"Somnolence"},{"rate":"5–10%","effect":"Dry mouth"},{"rate":"5–10%","effect":"Edema (peripheral)"},{"rate":"5–10%","effect":"Weight gain"},{"rate":"5–10%","effect":"Blurred vision"},{"rate":"5–10%","effect":"Ataxia"}]},"_chembl":{"chemblId":"CHEMBL1059","moleculeType":"Small molecule","molecularWeight":"159.23"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding to calcium channel subunits on nerve endings, pregabalin decreases calcium influx and subsequently reduces the release of glutamate, norepinephrine, and substance P. This dampens neuronal hyperexcitability and pain signal transmission. The drug is thought to work through multiple mechanisms including modulation of neurotransmitter release and stabilization of neuronal activity.","oneSentence":"Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:36.784Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury)"},{"name":"Partial-onset seizures (adjunctive therapy)"},{"name":"Fibromyalgia"},{"name":"Generalized anxiety disorder"}]},"trialDetails":[{"nctId":"NCT07495943","phase":"NA","title":"Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia","status":"NOT_YET_RECRUITING","sponsor":"Haydarpasa Numune Training and Research Hospital","startDate":"2026-05-04","conditions":"Fibromyalgia 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