{"id":"lycopene","rwe":[{"pmid":"41906951","year":"2026","title":"LmCCS Impacts the Flower Colour of Lily by Manipulating the Carotenoid Metabolic Flux.","finding":"","journal":"Physiologia plantarum","studyType":"Clinical Study"},{"pmid":"41905027","year":"2026","title":"Lycopene ameliorates swainsonine-induced autophagy in rat renal tubular epithelial cells via the endoplasmic reticulum stress UPR pathway.","finding":"","journal":"Research in veterinary science","studyType":"Clinical Study"},{"pmid":"41904292","year":"2026","title":"Effects of supplementary lighting with different spectral compositions on plant growth, fruit development, and quality formation of facility-grown tomatoes.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41901421","year":"2026","title":"Acute Combination of Nitrogen Deprivation and High Irradiance Induces the Simultaneous Accumulation of Astaxanthin and Lutein in Continuous Cultures of the Microalga Chromochloris zofingiensis.","finding":"","journal":"Plants (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41892229","year":"2026","title":"The ATP Binding Cassette (ABC) Transporter Gene Family in Lotus (Nelumbo Adans.): Genome-Wide Survey, Characterization and Gene Expression Profile.","finding":"","journal":"Biology","studyType":"Clinical Study"}],"tags":[{"label":"lycopene","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Lotion","category":"form"},{"label":"Active","category":"status"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anticarcinogenic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Antioxidants","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Radiation-Protective Agents","category":"pharmacology"}],"phase":"discontinued","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"lycored","offLabel":[],"synonyms":["lycopene","lycored","prolycopene"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Lycored","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"lycopene","explanation":"Think of Lycored like a shield for your cells. It helps protect them from damage caused by free radicals, which are unstable molecules that can harm your cells and contribute to diseases. By neutralizing these free radicals, Lycored helps keep your cells healthy and functioning properly.","oneSentence":"Lycored works by interacting with cell membranes to neutralize free radicals and reduce oxidative stress.","technicalDetail":"Lycopene, the active ingredient in Lycored, is a carotenoid that accumulates in cell membranes, where it quenches singlet oxygen and scavenges free radicals, thereby reducing oxidative stress and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4617","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=LYCOPENE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=LYCOPENE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:27:24.227618","biosimilars":[],"competitors":[],"genericName":"lycopene","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06944210","phase":"NA","title":"Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2025-05-17","conditions":["Healthy"],"enrollment":20,"completionDate":"2026-03-06"},{"nctId":"NCT07173166","phase":"NA","title":"Non-Pharmacological Interventions for Neurotoxicity in Hematologic Patients Receiving CAR-T Therapy","status":"RECRUITING","sponsor":"Instituto de Investigacion Sanitaria INCLIVA","startDate":"2025-09-30","conditions":["Hematologic Cancer"],"enrollment":100,"completionDate":"2028-09"},{"nctId":"NCT06979180","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.","status":"RECRUITING","sponsor":"Papillex Inc.","startDate":"2026-03","conditions":["CIN - Cervical Intraepithelial Neoplasia","CIN 1","CIN 2","HPV","Cervical Cells"],"enrollment":60,"completionDate":"2026-12"},{"nctId":"NCT07447687","phase":"PHASE1,PHASE2","title":"Soy Tomato Juice to Improve Outcomes in Pancreatitis","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2026-02","conditions":["Recurrent Acute Pancreatitis","Chronic Pancreatitis"],"enrollment":35,"completionDate":"2028-06"},{"nctId":"NCT05671562","phase":"NA","title":"The Effect of Lycopene on Sperm Quality in Men Attending Fertility Clinic","status":"COMPLETED","sponsor":"Sheffield Teaching Hospitals NHS Foundation Trust","startDate":"2023-05-03","conditions":["Total Motile Sperm Count"],"enrollment":34,"completionDate":"2025-12-31"},{"nctId":"NCT07380438","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device","status":"COMPLETED","sponsor":"Pharmanex","startDate":"2025-10-20","conditions":["Nutrition Assessment"],"enrollment":84,"completionDate":"2026-01-08"},{"nctId":"NCT03237702","phase":"NA","title":"Decipher Lethal Prostate Cancer Biology - Urine Metabolomics","status":"RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2017-08-01","conditions":["Significant Prostate Cancer"],"enrollment":2000,"completionDate":"2027-08-01"},{"nctId":"NCT05319548","phase":"NA","title":"Plant Pigments for Human Health: Impact of Lycopene and Anthocyanins on Bioefficacy of Provitamin A Carotenoids From Carrots","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2022-10-31","conditions":["Healthy"],"enrollment":12,"completionDate":"2023-05-11"},{"nctId":"NCT02100774","phase":"","title":"Effect of Genetic Variants on Fat-soluble Vitamin Bioavailability","status":"COMPLETED","sponsor":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","startDate":"2009-01","conditions":["Biological Availability of Vitamins and Micronutrients"],"enrollment":45,"completionDate":"2013-12"},{"nctId":"NCT01748916","phase":"NA","title":"Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2011-06","conditions":["Focus of Study: Carotenoid Absorption"],"enrollment":16,"completionDate":"2011-11"},{"nctId":"NCT01696773","phase":"NA","title":"Carotenoid and Flavonoid Absorption From Red and Tangerine-Type Tomatoes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ohio State University","startDate":"2012-10","conditions":["Carotenoid and Flavonoid Absorption"],"enrollment":12,"completionDate":"2027-12"},{"nctId":"NCT06588218","phase":"NA","title":"Effect of Watermelon on Gut and Cardiometabolic Health","status":"RECRUITING","sponsor":"Florida State University","startDate":"2024-10-13","conditions":["Obesity and Overweight","Dysbiosis"],"enrollment":36,"completionDate":"2026-08"},{"nctId":"NCT06137833","phase":"NA","title":"Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy","status":"RECRUITING","sponsor":"Pharmanutra S.p.a.","startDate":"2023-11-27","conditions":["Fatigue","Breast Cancer"],"enrollment":92,"completionDate":"2025-12-31"},{"nctId":"NCT07120035","phase":"NA","title":"Lycopene-rich Juice Intervention to Reduce Inflammatory Markers Among Adults With Obesity","status":"COMPLETED","sponsor":"East Carolina University","startDate":"2024-03-27","conditions":["Inflammatory Markers"],"enrollment":27,"completionDate":"2024-09-16"},{"nctId":"NCT07117110","phase":"NA","title":"Lycopene as a Dietary Compliance Biomarker","status":"RECRUITING","sponsor":"Erasmus Medical Center","startDate":"2025-07-11","conditions":["Healthy"],"enrollment":10,"completionDate":"2025-12-31"},{"nctId":"NCT05891977","phase":"NA","title":"Effect of Tomato Paste Consumption on the Microbiota-gut-brain Axis in Healthy Adults","status":"COMPLETED","sponsor":"University of Barcelona","startDate":"2023-10-25","conditions":["Microbiota","Cognitive Function","Healthy Lifestyle"],"enrollment":47,"completionDate":"2024-12-04"},{"nctId":"NCT05614349","phase":"PHASE3","title":"Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings","status":"ACTIVE_NOT_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2023-01-16","conditions":["COVID-19"],"enrollment":797,"completionDate":"2025-06-28"},{"nctId":"NCT06574685","phase":"NA","title":"Efficacy of Twinkle Eyez Supplementation in Improving Ocular Health and Immunity","status":"COMPLETED","sponsor":"Ecolite Group","startDate":"2024-07-01","conditions":["Dry Eye Disease","Immunity"],"enrollment":110,"completionDate":"2024-07-31"},{"nctId":"NCT06504472","phase":"NA","title":"A Randomized Triple-Blind Placebo-Controlled Study to Evaluate the Effects of a Supplement on Lower Urinary Tract Symptoms in Men.","status":"COMPLETED","sponsor":"Optimale","startDate":"2024-02-07","conditions":["Lower Urinary Tract Symptoms","Benign Prostatic Hyperplasia","Erectile Dysfunction"],"enrollment":80,"completionDate":"2024-06-24"},{"nctId":"NCT05306002","phase":"NA","title":"Nutritional Intervention and DNA Damage of Patients With HBOC","status":"COMPLETED","sponsor":"Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado","startDate":"2017-11-28","conditions":["HBOC Syndrome","DNA Damage","Nutrition Therapy"],"enrollment":34,"completionDate":"2022-12-31"},{"nctId":"NCT00937742","phase":"NA","title":"The Effect of Processed Tomato Products on CVD Risks","status":"COMPLETED","sponsor":"Penn State University","startDate":"2008-01","conditions":["Cardiovascular Disease"],"enrollment":32,"completionDate":"2009-04"},{"nctId":"NCT05836909","phase":"NA","title":"Regulation of Lipid Metabolism in Guangzhou Individuals With Dyslipidemia by Red Yeast Rice, Phytosterol Esters and Lycopene","status":"UNKNOWN","sponsor":"Lili Yang","startDate":"2023-05-01","conditions":["Hypercholesterolemia"],"enrollment":80,"completionDate":"2024-04-30"},{"nctId":"NCT05527106","phase":"NA","title":"Evaluation of the Effect of Citicoline and Docosahexaenoic Acid (DHA) on the Visual Function of Patients With Glaucoma","status":"COMPLETED","sponsor":"Institut Catala de Retina","startDate":"2015-03-12","conditions":["Glaucoma"],"enrollment":73,"completionDate":"2022-05-25"},{"nctId":"NCT05328388","phase":"NA","title":"A Study to Evaluate the Effect of Lycomato on Skin Attributes in Healthy Participants.","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2022-01-01","conditions":["Skin"],"enrollment":50,"completionDate":"2022-03-15"},{"nctId":"NCT03783013","phase":"NA","title":"Tomato Juice for Health Study","status":"TERMINATED","sponsor":"USDA Beltsville Human Nutrition Research Center","startDate":"2019-01-08","conditions":["Healthy Volunteers"],"enrollment":19,"completionDate":"2021-08-25"},{"nctId":"NCT03608254","phase":"","title":"Acute Effects of Watermelon on Vascular Function and Serum Lycopene","status":"COMPLETED","sponsor":"University of Alabama, Tuscaloosa","startDate":"2015-11-05","conditions":["Vascular Health of Postmenopausal Women"],"enrollment":11,"completionDate":"2016-12-08"},{"nctId":"NCT03836651","phase":"NA","title":"Dietary Intervention in Persons With Metabolic Syndrome","status":"COMPLETED","sponsor":"Martha Biddle","startDate":"2018-12-01","conditions":["Metabolic Syndrome"],"enrollment":94,"completionDate":"2021-09-23"},{"nctId":"NCT03167268","phase":"PHASE2","title":"Panitumumab Skin Toxicity Prevention Trial","status":"UNKNOWN","sponsor":"Ospedale San Carlo Borromeo","startDate":"2016-08-03","conditions":["Colorectal Cancer Metastatic","Skin Toxicity"],"enrollment":28,"completionDate":"2021-11-30"},{"nctId":"NCT01882985","phase":"PHASE2","title":"Docetaxel Plus Lycopene in Castration Resistant, Chemotherapy-Naïve Prostate Cancer Patients","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2010-12","conditions":["Adenocarcinoma of the Prostate","Recurrent Prostate Cancer","Stage I Prostate Cancer","Stage IIA Prostate Cancer","Stage IIB Prostate Cancer","Stage III Prostate Cancer"],"enrollment":14,"completionDate":"2016-10"},{"nctId":"NCT04652739","phase":"PHASE2,PHASE3","title":"Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus","status":"COMPLETED","sponsor":"Nourhan M.Aly","startDate":"2018-10-01","conditions":["Erosive Lichen Planus"],"enrollment":20,"completionDate":"2019-03-10"},{"nctId":"NCT03825042","phase":"NA","title":"Effect of an Antioxidants Mix on Cognitive Performance and Well Being: The Bacopa, Licopene, Astaxantina, Vitamin B12","status":"COMPLETED","sponsor":"A. Menarini Industrie Farmaceutiche Riunite S.r.l.","startDate":"2018-01-23","conditions":["Cognitive Dysfunction"],"enrollment":80,"completionDate":"2018-10-29"},{"nctId":"NCT03820245","phase":"NA","title":"Effect of Short-term Annatto Carotenoids Supplementation on Oxidative Stress Status in Healthy Individuals","status":"COMPLETED","sponsor":"Universidade Federal de Santa Maria","startDate":"2016-08-24","conditions":["Oxidative Stress","Atherosclerosis"],"enrollment":16,"completionDate":"2018-07-25"},{"nctId":"NCT00450749","phase":"PHASE2","title":"Lycopene in Treating Patients Undergoing Radical Prostatectomy for Prostate Cancer","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2008-02","conditions":["Adenocarcinoma of the Prostate","Stage I Prostate Cancer","Stage II Prostate Cancer","Stage III Prostate Cancer"],"enrollment":10,"completionDate":"2010-05"},{"nctId":"NCT01443026","phase":"PHASE2","title":"The Effects of Lycopene on High Risk Prostatic Tissue","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2006-02","conditions":["Intraepithelial Prostatic Neoplasia","Prostatic Neoplasms"],"enrollment":66,"completionDate":"2009-04"},{"nctId":"NCT02421887","phase":"PHASE2","title":"Males, Antioxidants, and Infertility Trial","status":"COMPLETED","sponsor":"Yale University","startDate":"2015-12","conditions":["Male Infertility"],"enrollment":171,"completionDate":"2018-12"},{"nctId":"NCT02144649","phase":"NA","title":"Tangerine or Red Tomato Juice in Treating Patients With Prostate Cancer Undergoing Surgery","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2015-06","conditions":["Stage I Prostate Cancer","Stage IIA Prostate Cancer","Stage IIB Prostate Cancer","Stage III Prostate Cancer","Stage IV Prostate Cancer"],"enrollment":45,"completionDate":"2016-09-22"},{"nctId":"NCT03772808","phase":"NA","title":"Effects of LycoComfort™ Supplementation on Symptoms Associated With Lower Urinary Tract Symptoms (LUTS)","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2018-11-16","conditions":["BPH","Lower Urinary Tract Symptoms"],"enrollment":52,"completionDate":"2019-06-15"},{"nctId":"NCT03460860","phase":"NA","title":"Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging","status":"COMPLETED","sponsor":"United Laboratories","startDate":"2018-03-05","conditions":["Skin Aging","Wrinkles"],"enrollment":100,"completionDate":"2019-02-07"},{"nctId":"NCT03964935","phase":"PHASE2","title":"Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment","status":"UNKNOWN","sponsor":"University of Baghdad","startDate":"2018-12-01","conditions":["Periodontal Pocket"],"enrollment":30,"completionDate":"2019-08-30"},{"nctId":"NCT01968369","phase":"NA","title":"Effects of Tomato Sauce on Endothelial Dysfunction Induced by a High Fat Meal in Healthy Subjects","status":"COMPLETED","sponsor":"Universita di Verona","startDate":"2013-10","conditions":["Endothelial Dysfunction"],"enrollment":19,"completionDate":"2015-12"},{"nctId":"NCT01692340","phase":"PHASE1,PHASE2","title":"Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2012-02","conditions":["Healthy"],"enrollment":12,"completionDate":"2013-11"},{"nctId":"NCT03068377","phase":"NA","title":"The Effects of LycoRed Phytonutrient and Vitamin Supplement (a.k.a. LYC-001e) on Ocular Blood Flow","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2017-03-20","conditions":["Ocular Blood Flow"],"enrollment":60,"completionDate":"2018-12-30"},{"nctId":"NCT02550483","phase":"NA","title":"Novel Metabolites of Beta-Carotene and Lycopene","status":"COMPLETED","sponsor":"USDA Beltsville Human Nutrition Research Center","startDate":"2015-09","conditions":["Healthy"],"enrollment":36,"completionDate":"2015-11"},{"nctId":"NCT03492593","phase":"NA","title":"Lycopene and Beta-carotene Metabolism in the Digestive Tract of Healthy Men","status":"COMPLETED","sponsor":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","startDate":"2014-09","conditions":["Digestion Chambers","Stability and Metabolism of Carotenoids and Vitamin E"],"enrollment":20,"completionDate":"2016-03"},{"nctId":"NCT03463967","phase":"NA","title":"Effects of Tomato Products in Children With NAFLD","status":"UNKNOWN","sponsor":"Federico II University","startDate":"2016-10","conditions":["NAFLD"],"enrollment":61,"completionDate":"2018-06"},{"nctId":"NCT00744549","phase":"PHASE2","title":"Study of Antioxidants on MRI Detectable Early Stage Prostate Cancer Among Men on Active Surveillance","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2008-05","conditions":["Cancer of the Prostate","Prostate Cancer","Prostatic Neoplasms"],"enrollment":16,"completionDate":"2013-12"},{"nctId":"NCT01105338","phase":"PHASE2,PHASE3","title":"Lycopene or Green Tea for Men at Risk of Prostate Cancer","status":"COMPLETED","sponsor":"University of Bristol","startDate":"2009-08","conditions":["Prostate Cancer"],"enrollment":126,"completionDate":"2010-08"},{"nctId":"NCT01949519","phase":"PHASE1","title":"Docetaxel and Lycopene in Metastatic Prostate Cancer","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2013-11","conditions":["Adenocarcinoma of the Prostate"],"enrollment":24,"completionDate":"2017-07-12"},{"nctId":"NCT01667510","phase":"NA","title":"Effect of Cardio Mato (Grade A Lyc-O-Mato, a Tomato Extracted Lycopene) on Blood Pressure","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2012-08","conditions":["Prehypertension"],"enrollment":80,"completionDate":"2013-08"},{"nctId":"NCT01665469","phase":"NA","title":"Effect of Tomato Extracted Lycopene on Postprandial Oxidation and inflammation in Healthy Weight Men and Women","status":"COMPLETED","sponsor":"LycoRed Ltd.","startDate":"2012-11","conditions":["Postprandial Oxidation and inflammation"],"enrollment":30,"completionDate":"2013-06"},{"nctId":"NCT00844792","phase":"PHASE2","title":"Study of Antioxidants on Prostate Tumors in Men Undergoing Radical Prostatectomy for Prostate Cancer","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2008-10","conditions":["Cancer of the Prostate","Prostate Cancer","Prostatic Neoplasms"],"enrollment":48,"completionDate":"2013-12"},{"nctId":"NCT01859390","phase":"PHASE2","title":"Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2013-06","conditions":["Cystic Fibrosis"],"enrollment":73,"completionDate":"2016-07"},{"nctId":"NCT03203746","phase":"PHASE1,PHASE2","title":"Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis","status":"COMPLETED","sponsor":"Maie Sami tawfik","startDate":"2015-09-28","conditions":["Chronic Periodontitis"],"enrollment":24,"completionDate":"2016-12-14"},{"nctId":"NCT00669656","phase":"PHASE2","title":"Herbal Therapy for Treatment of Recurrent Prostate Cancer","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2008-07-06","conditions":["Prostate Cancer"],"enrollment":43,"completionDate":"2014-10-14"},{"nctId":"NCT01733017","phase":"PHASE2","title":"Nutrition Intervention to Decrease Symptoms in Patients With Heart Failure","status":"COMPLETED","sponsor":"Terry Lennie","startDate":"2011-11","conditions":["Heart Failure"],"enrollment":150,"completionDate":"2017-01"},{"nctId":"NCT02246985","phase":"NA","title":"Bioavailability of Carotenoids Added Into Processed Foods","status":"COMPLETED","sponsor":"University of Aberdeen","startDate":"2014-07","conditions":["Cardiovascular Disease"],"enrollment":20,"completionDate":"2016-07"},{"nctId":"NCT00068731","phase":"PHASE2","title":"Lycopene in Treating Patients With Metastatic Prostate Cancer","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2004-01","conditions":["Prostate Cancer"],"enrollment":47,"completionDate":"2009-10"},{"nctId":"NCT02709837","phase":"NA","title":"Impact of Food Process and Mastication on Nutrient Bioavailability","status":"COMPLETED","sponsor":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","startDate":"2013-06","conditions":["Nutrition"],"enrollment":10,"completionDate":"2014-01"},{"nctId":"NCT02587117","phase":"PHASE4","title":"A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2013-02","conditions":["Oral Lichen Planus"],"enrollment":28,"completionDate":"2014-03"},{"nctId":"NCT00402285","phase":"NA","title":"Lycopene or Omega-3 Fatty Acid Nutritional Supplements in Treating Patients With Stage I or Stage II Prostate Cancer","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2003-04","conditions":["Prostate Cancer"],"enrollment":84,"completionDate":"2008-01"},{"nctId":"NCT02369666","phase":"NA","title":"LycoRed 40051 Product as a Countermeasure to Exercise Stress","status":"COMPLETED","sponsor":"Appalachian State University","startDate":"2014-11","conditions":["Inflammation"],"enrollment":20,"completionDate":"2015-07"},{"nctId":"NCT01377961","phase":"NA","title":"Effect of Lycopene and Isoflavones on Glucose Metabolism","status":"WITHDRAWN","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2010-09","conditions":["Metabolic Syndrome","Diabetes Mellitus, Non-Insulin-Dependent"],"enrollment":0,"completionDate":"2015-08"},{"nctId":"NCT01100385","phase":"NA","title":"TomVasc - Vascular Effects of Tomato Extract","status":"COMPLETED","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2010-02","conditions":["Ischemic Heart Disease","Transient Ischemic Attack","Stroke","Peripheral Vascular Disease"],"enrollment":72,"completionDate":"2012-05"},{"nctId":"NCT01321268","phase":"NA","title":"Safety and Efficacy of a Dietary Supplement in Females With Cellulite","status":"TERMINATED","sponsor":"dsm-firmenich Switzerland AG","startDate":"2011-05","conditions":["Cellulite (Orange Peel Skin)"],"enrollment":8,"completionDate":"2012-07"},{"nctId":"NCT00178113","phase":"PHASE1","title":"A Pilot Study of Lycopene Supplementation in Prostatic Intraepithelial Neoplasia","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2003-07","conditions":["Prostatic Intraepithelial Neoplasia"],"enrollment":80,"completionDate":"2004-07"},{"nctId":"NCT00450957","phase":"PHASE1","title":"Lycopene in Healthy Male Participants","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2006-10","conditions":["Healthy, no Evidence of Disease","Prostate Cancer"],"enrollment":20,"completionDate":"2007-11"},{"nctId":"NCT01102504","phase":"NA","title":"Supplementation of Lycopene in Carotid Atheroma","status":"WITHDRAWN","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2015-08","conditions":["Carotid Atherosclerotic Disease"],"enrollment":0,"completionDate":"2018-04"},{"nctId":"NCT02348164","phase":"NA","title":"Human Lycopene and Beta-cryptoxanthin Absorption From Citrus Fruit","status":"COMPLETED","sponsor":"USDA, Western Human Nutrition Research Center","startDate":"2007-12","conditions":["Bioavailability of Carotenoids"],"enrollment":23,"completionDate":"2009-02"},{"nctId":"NCT01665742","phase":"NA","title":"Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents","status":"COMPLETED","sponsor":"University College Dublin","startDate":"2012-01","conditions":["Overweight","Obesity"],"enrollment":58,"completionDate":"2013-11"},{"nctId":"NCT02292524","phase":"NA","title":"Prostate Biomarkers in Men Consuming Tomato Products","status":"COMPLETED","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2002-05","conditions":["Prostate Cancer"],"enrollment":33,"completionDate":"2004-10"},{"nctId":"NCT02263352","phase":"PHASE4","title":"A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre","startDate":"2013-01","conditions":["Positive Regulation of Oxidative Stress Process"],"enrollment":40,"completionDate":"2013-08"},{"nctId":"NCT00939237","phase":"PHASE3","title":"Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2009-07","conditions":["Coronary Heart Disease"],"enrollment":213,"completionDate":"2011-05"},{"nctId":"NCT01427426","phase":"PHASE4","title":"Does a Nutritional Supplement Increase Vitality, Energy and Perceived Well Being?","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2012-01","conditions":["Healthy"],"enrollment":120,"completionDate":"2012-06"},{"nctId":"NCT00872664","phase":"NA","title":"Skin and Serum Carotenoids in Preterm Infants Fed on a Formula Supplemented With Carotenoids","status":"COMPLETED","sponsor":"University of Utah","startDate":"2009-09","conditions":["Retinopathy of Prematurity"],"enrollment":36,"completionDate":"2013-06"},{"nctId":"NCT00322114","phase":"NA","title":"Lycopene in Preventing Prostate Cancer in Healthy Participants","status":"UNKNOWN","sponsor":"University of Illinois at Chicago","startDate":"2006-02","conditions":["Prostate Cancer"],"enrollment":150,"completionDate":""},{"nctId":"NCT00416390","phase":"NA","title":"Lycopene in Treating Patients With Prostate Cancer or Benign Prostatic Hyperplasia","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"","conditions":["Nonmalignant Neoplasm","Prostate Cancer"],"enrollment":120,"completionDate":"2011-03"},{"nctId":"NCT01534533","phase":"PHASE2,PHASE3","title":"Effects of Lutein Supplementation on Subclinical Atherosclerosis","status":"COMPLETED","sponsor":"Peking University","startDate":"2010-06","conditions":["Carotid Atherosclerosis","Carotid Intimal Medial Thickness 1"],"enrollment":192,"completionDate":"2012-06"},{"nctId":"NCT00093561","phase":"PHASE1","title":"Lycopene in Preventing Prostate Cancer in Healthy Participants","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2004-08","conditions":["Prostate Cancer"],"enrollment":0,"completionDate":"2006-02"},{"nctId":"NCT00006078","phase":"PHASE1","title":"Lycopene In Preventing of Prostate Cancer","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2000-06","conditions":["Prostate Cancer"],"enrollment":0,"completionDate":"2005-01"},{"nctId":"NCT00416325","phase":"PHASE1","title":"Lycopene in Preventing Prostate Cancer in Patients Who Are at High Risk of Developing Prostate Cancer","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"","conditions":["Prostate Cancer"],"enrollment":18,"completionDate":"2006-09"},{"nctId":"NCT01342666","phase":"NA","title":"Tomato Consumption and High Density Lipoprotein-cholesterol","status":"COMPLETED","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2009-03","conditions":["Hypoalphalipoproteinemia"],"enrollment":50,"completionDate":"2011-12"},{"nctId":"NCT00637858","phase":"NA","title":"Effect of Different Doses of Tomato Lycopene on Blood Pressure in Pre-hypertensive Otherwise Healthy Subjects","status":"TERMINATED","sponsor":"Soroka University Medical Center","startDate":"2008-10","conditions":["Hypertension"],"enrollment":130,"completionDate":"2011-01"},{"nctId":"NCT00042731","phase":"NA","title":"Isoflavones & Lycopene in Localized Prostate Ca:Prior to Radical Prostatectomy","status":"COMPLETED","sponsor":"H. Lee Moffitt Cancer Center and Research Institute","startDate":"2002-07","conditions":["Prostate Cancer"],"enrollment":79,"completionDate":"2006-08"},{"nctId":"NCT01488656","phase":"NA","title":"Effects of Dietary Supplements on Response to Air Pollution","status":"COMPLETED","sponsor":"Utah State University","startDate":"2011-11","conditions":["Inflammation"],"enrollment":66,"completionDate":"2012-06"},{"nctId":"NCT01286909","phase":"PHASE3","title":"Efficacy of Laflavon in Lowering Triglycerides and Raising High-Density Lipoprotein (HDL)","status":"UNKNOWN","sponsor":"Omicron Pharmaceuticals","startDate":"2011-01","conditions":["Metabolic Disease"],"enrollment":40,"completionDate":"2011-06"},{"nctId":"NCT01221558","phase":"PHASE3","title":"Effects of Lycopene on Oxidative Stress and Markers of Endothelial Function Healthy Men","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2009-07","conditions":["Healthy Men"],"enrollment":126,"completionDate":"2010-09"},{"nctId":"NCT01199549","phase":"","title":"Bioavailability Study of Different Dietary Antioxidants in Volunteers","status":"COMPLETED","sponsor":"Cambridge Theranostics Ltd","startDate":"2009-09","conditions":["Cardiovascular Disease"],"enrollment":90,"completionDate":"2010-09"},{"nctId":"NCT00905931","phase":"PHASE2","title":"Lycopene Following Aneurysmal Subarachnoid Haemorrhage","status":"UNKNOWN","sponsor":"University of Cambridge","startDate":"2010-09","conditions":["Subarachnoid Hemorrhage","Aneurysm"],"enrollment":124,"completionDate":"2012-10"},{"nctId":"NCT00172367","phase":"PHASE2","title":"Chemoprevention Trial for Uremia-Associated Urothelial Carcinoma","status":"WITHDRAWN","sponsor":"National Taiwan University Hospital","startDate":"2006-01","conditions":["Carcinoma, Transitional Cell"],"enrollment":80,"completionDate":""},{"nctId":"NCT00656214","phase":"PHASE2","title":"Treatmant of Oral Lichen Planus With Lycopene","status":"COMPLETED","sponsor":"College of Dental Sciences, India","startDate":"2004-12","conditions":["Lichen Planus, Oral"],"enrollment":30,"completionDate":"2006-07"},{"nctId":"NCT00154843","phase":"PHASE2","title":"A Clinical Study to Determine Factors Affecting Absorption and Serum Levels of Lycopene After Supplementation","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2004-03","conditions":["BPH"],"enrollment":74,"completionDate":"2005-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Lotion","formulations":[{"form":"LOTION","route":"TOPICAL","productName":"IQQU Advanced Sunscreen SPF 50"}]},"crossReferences":{"NUI":"N0000148836","NDDF":"009145","UNII":"SB0N2N0WV6","VUID":"4021425","CHEBI":"CHEBI:15948","VANDF":"4021425","RXNORM":"29008","UMLSCUI":"C0065331","ChEMBL_ID":"CHEMBL501174","DRUGBANK_ID":"DB11231","PDB_CHEM_ID":" LYC","PUBCHEM_CID":"446925","MESH_DESCRIPTOR_UI":"D000077276"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7284,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar-Apr","pmid":"41906951","title":"LmCCS Impacts the Flower Colour of Lily by Manipulating the Carotenoid Metabolic Flux.","journal":"Physiologia plantarum"},{"date":"2026 Mar 28","pmid":"41905027","title":"Lycopene ameliorates swainsonine-induced autophagy in rat renal tubular epithelial cells via the endoplasmic reticulum stress UPR pathway.","journal":"Research in veterinary science"},{"date":"2026 Mar 28","pmid":"41904292","title":"Effects of supplementary lighting with different spectral compositions on plant growth, fruit development, and quality formation of facility-grown tomatoes.","journal":"Scientific reports"},{"date":"2026 Mar 14","pmid":"41901421","title":"Acute Combination of Nitrogen Deprivation and High Irradiance Induces the Simultaneous Accumulation of Astaxanthin and Lutein in Continuous Cultures of the Microalga Chromochloris zofingiensis.","journal":"Plants (Basel, Switzerland)"},{"date":"2026 Mar 14","pmid":"41892229","title":"The ATP Binding Cassette (ABC) Transporter Gene Family in Lotus (Nelumbo Adans.): Genome-Wide Survey, Characterization and Gene Expression Profile.","journal":"Biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lycored is a lycopene-based small molecule developed by a company, currently owned by a pharmaceutical company. It is used to treat various conditions, although its exact target and approved indications are unknown. The commercial status of Lycored is unclear, with no information available on its patent status or generic availability. As a small molecule, Lycored is designed to interact with specific biological pathways to produce its therapeutic effects. Further research is needed to fully understand its pharmacological properties and clinical applications.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}