{"id":"ly900003","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL2108287","moleculeType":"Oligonucleotide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"LY900003 binds to and activates the GLP-1 receptor, which enhances insulin secretion in response to glucose, slows gastric emptying, and increases satiety signals to the brain. This multi-modal action reduces blood glucose levels and decreases appetite, making it suitable for treating type 2 diabetes and obesity.","oneSentence":"LY900003 is a GLP-1 receptor agonist that mimics glucagon-like peptide-1 to regulate blood glucose and promote weight loss.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:37.773Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Obesity or weight management"}]},"trialDetails":[{"nctId":"NCT00003236","phase":"PHASE2","title":"Chemotherapy in Treating Women With Previously Treated Metastatic Breast Cancer","status":"COMPLETED","sponsor":"Eastern Cooperative Oncology Group","startDate":"1998-07-13","conditions":"Breast Cancer","enrollment":""},{"nctId":"NCT00017407","phase":"PHASE3","title":"Carboplatin and Paclitaxel With or Without ISIS 3521 in Treating Patients With Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Ionis Pharmaceuticals, Inc.","startDate":"2000-10-13","conditions":"Lung Cancer","enrollment":""},{"nctId":"NCT00003989","phase":"PHASE2","title":"ISIS 3521 in Treating Patients With Advanced, Unresectable, or Metastatic Non-small Cell Lung Cancer or Unresectable or Metastatic Melanoma","status":"COMPLETED","sponsor":"European Organisation for Research and Treatment of Cancer - EORTC","startDate":"1998-06","conditions":"Lung Cancer, Melanoma (Skin)","enrollment":50},{"nctId":"NCT00034268","phase":"PHASE3","title":"A Phase 3 Trial of LY900003 Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2002-03","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":""},{"nctId":"NCT00042679","phase":"PHASE2","title":"A Phase 2 Trial of Antisense Nucleotide to PKC-Alpha (LY900003, ISIS 3521) Plus Gemcitabine and Carboplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer.","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2002-06","conditions":"Carcinoma, Non-Small-Cell Lung, Pulmonary Neoplasms, Neoplasms, Lung","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"HAEMOGLOBIN DECREASED"},{"count":1,"reaction":"ABDOMINAL PAIN"},{"count":1,"reaction":"ACUTE CORONARY SYNDROME"},{"count":1,"reaction":"BLOOD POTASSIUM ABNORMAL"},{"count":1,"reaction":"DYSPNOEA"},{"count":1,"reaction":"LOBAR PNEUMONIA"},{"count":1,"reaction":"PLATELET COUNT DECREASED"},{"count":1,"reaction":"PNEUMONIA"},{"count":1,"reaction":"SHOCK"},{"count":1,"reaction":"THROMBOCYTOPENIA"}],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"LY900003","genericName":"LY900003","companyName":"Eli Lilly and Company","companyId":"eli-lilly","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LY900003 is a GLP-1 receptor agonist that mimics glucagon-like peptide-1 to regulate blood glucose and promote weight loss. Used for Type 2 diabetes mellitus, Obesity or weight management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}