{"id":"lutein-zeaxanthin-and-dha-epa","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Fish-like aftertaste (from omega-3 components)"},{"rate":null,"effect":"Mild nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lutein and zeaxanthin are carotenoids that filter harmful blue light and act as antioxidants in the macula, while DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) are omega-3 polyunsaturated fatty acids that support retinal cell membrane integrity and reduce inflammation. Together, these nutrients are hypothesized to slow the progression of age-related macular degeneration (AMD) by reducing oxidative stress and supporting photoreceptor function.","oneSentence":"Lutein, zeaxanthin, and omega-3 fatty acids (DHA/EPA) accumulate in the retina to protect against oxidative damage and support macular health.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:50.127Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Age-related macular degeneration (AMD), intermediate to advanced stages"}]},"trialDetails":[{"nctId":"NCT06738446","phase":"NA","title":"Dietary Supplementation on Tear Secretion and Inflammation in DES","status":"COMPLETED","sponsor":"Shih Chien Huang","startDate":"2021-09-27","conditions":"Dry Eye Syndrome (DES)","enrollment":52},{"nctId":"NCT05533658","phase":"NA","title":"The Effects of VisionPure™ on Indices of Vision Health and Cognitive Function","status":"COMPLETED","sponsor":"Applied Science & Performance Institute","startDate":"2022-08-01","conditions":"Eye Health, Vision, Cognitive Function","enrollment":15},{"nctId":"NCT05527106","phase":"NA","title":"Evaluation of the Effect of Citicoline and Docosahexaenoic Acid (DHA) on the Visual Function of Patients With Glaucoma","status":"COMPLETED","sponsor":"Institut Catala de Retina","startDate":"2015-03-12","conditions":"Glaucoma","enrollment":73},{"nctId":"NCT04117022","phase":"NA","title":"Diabetic Retinopathy Functional Evaluation Study: Monitoring Carotenoid Vitamins Treatment Using ERG","status":"UNKNOWN","sponsor":"ZeaVision, LLC","startDate":"2019-09-01","conditions":"Diabetes, Diabetic Retinopathy","enrollment":45},{"nctId":"NCT03862872","phase":"NA","title":"Effects of Bend Beauty's Anti-Aging Formula on Inflammatory Markers","status":"WITHDRAWN","sponsor":"Bend Beauty Inc.","startDate":"2020-02","conditions":"Inflammation, Skin Abnormalities, Skin Pigment","enrollment":""},{"nctId":"NCT03866005","phase":"NA","title":"Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema","status":"UNKNOWN","sponsor":"ZeaVision, LLC","startDate":"2019-11-01","conditions":"Center-involved Diabetic Macular Edema (CI-DME)","enrollment":150},{"nctId":"NCT00345176","phase":"PHASE3","title":"Age-Related Eye Disease Study 2 (AREDS2)","status":"COMPLETED","sponsor":"National Eye Institute (NEI)","startDate":"2006-09","conditions":"Age-related Macular Degeneration, Cataract","enrollment":4203},{"nctId":"NCT02264938","phase":"NA","title":"Drusen Morphology Changes in Nonexudative Age-related Degeneration After Oral Antioxidants Supplementation","status":"COMPLETED","sponsor":"Germans Trias i Pujol Hospital","startDate":"2013-01","conditions":"Macular Degeneration","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Lutein/zeaxanthin and DHA/EPA","genericName":"Lutein/zeaxanthin and DHA/EPA","companyName":"National Eye Institute (NEI)","companyId":"national-eye-institute-nei","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lutein, zeaxanthin, and omega-3 fatty acids (DHA/EPA) accumulate in the retina to protect against oxidative damage and support macular health. Used for Age-related macular degeneration (AMD), intermediate to advanced stages.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}